Chakragati mouse is an insertional transgenic mouse mutant

Mutant

In biology and especially genetics, a mutant is an individual, organism, or new genetic character, arising or resulting from an instance of mutation, which is a base-pair sequence change within the DNA of a gene or chromosome of an organism resulting in the creation of a new character or trait not...

 displaying hyperactive behaviour and circling. It is also deficient in prepulse inhibition

Prepulse inhibition

Prepulse Inhibition is a neurological phenomenon in which a weaker prestimulus inhibits the reaction of an organism to a subsequent strong startling stimulus . The stimuli are usually acoustic, but tactile stimuli Prepulse Inhibition (PPI) is a neurological phenomenon in which a weaker...

, latent inhibition

Latent inhibition

Latent inhibition is a technical term used in Classical conditioning. A stimulus that has not had any significance in the past takes longer to acquire meaning than a new stimulus...

 and has brain abnormalities such as lateral ventricular enlargement that are typical to endophenotypic models of schizophrenia

Schizophrenia

Schizophrenia is a mental disorder characterized by a disintegration of thought processes and of emotional responsiveness. It most commonly manifests itself as auditory hallucinations, paranoid or bizarre delusions, or disorganized speech and thinking, and it is accompanied by significant social...

, which make it useful in screening for antipsychotic

Antipsychotic

An antipsychotic is a tranquilizing psychiatric medication primarily used to manage psychosis , particularly in schizophrenia and bipolar disorder. A first generation of antipsychotics, known as typical antipsychotics, was discovered in the 1950s...

 drug candidates. The mouse is currently licensed by Chakra Biotech.

External links

• Chakragati gene information on the ckr gene from Mouse Genome Informatics
  Mouse Genome Informatics
  The Mouse Genome Informatics website is hosted by The Jackson Laboratory. According to , MGI "provides integrated access to data on the genetics, genomics and biology of the laboratory mouse".-External links:* *...
  
  database