Chondroitin sulfate proteoglycan
Encyclopedia
Chondroitin sulfate proteoglycans (CSPGs) are proteoglycans consisting of a core protein and chondroitin sulfate
. They are structural components of a variety of human tissues, for example of cartilage
.
The following CSPGs have been identified:
Chondroitin sulfate
Chondroitin sulfate is a sulfated glycosaminoglycan composed of a chain of alternating sugars . It is usually found attached to proteins as part of a proteoglycan. A chondroitin chain can have over 100 individual sugars, each of which can be sulfated in variable positions and quantities...
. They are structural components of a variety of human tissues, for example of cartilage
Cartilage
Cartilage is a flexible connective tissue found in many areas in the bodies of humans and other animals, including the joints between bones, the rib cage, the ear, the nose, the elbow, the knee, the ankle, the bronchial tubes and the intervertebral discs...
.
The following CSPGs have been identified:
- CSPG1 (aggrecan)
- CSPG2 (versican). Versican has chains of dermatan sulfateDermatan sulfateDermatan sulfate is a glycosaminoglycan found mostly in skin, but also in blood vessels, heart valves, tendons, and lungs....
in addition to chondroitin sulfate. - CSPG3 (neurocan)
- CSPG4CSPG4Chondroitin sulfate proteoglycan 4 or melanoma-associated chondroitin sulfate proteoglycan is a chondroitin sulfate proteoglycan that in humans is encoded by the CSPG4 gene....
(melanoma-associated chondroitin sulfate proteoglycan) - CSPG5CSPG5Chondroitin sulfate proteoglycan 5 is a protein that in humans is encoded by the CSPG5 gene.-Further reading:...
- CSPG6 (SMC3, structural maintenance of chromosomes 3)
- CSPG7 (brevican)
- CSPG8 (CD44, cluster of differentiation 44)