Chromone
Encyclopedia
Chromone is a derivative of benzopyran with a substituted keto
group on the pyran
ring. It is an isomer of coumarin
.
Derivatives of chromone are collectively known as chromones. Most, though not all, chromones are also phenylpropanoid
s.
6,7-dimethoxy-2,3-dihydrochromone has been isolated from Sarcolobus globosus
.
Ketone
In organic chemistry, a ketone is an organic compound with the structure RCR', where R and R' can be a variety of atoms and groups of atoms. It features a carbonyl group bonded to two other carbon atoms. Many ketones are known and many are of great importance in industry and in biology...
group on the pyran
Pyran
In chemistry, a pyran, or oxine, is a six-membered heterocyclic, non-aromatic ring, consisting of five carbon atoms and one oxygen atom and containing two double bonds. The molecular formula is C5H6O. There are two isomers of pyran that differ by the location of the double bonds...
ring. It is an isomer of coumarin
Coumarin
Coumarin is a fragrant chemical compound in the benzopyrone chemical class, found in many plants, notably in high concentration in the tonka bean , vanilla grass , sweet woodruff , mullein , sweet grass , cassia cinnamon and sweet clover...
.
Derivatives of chromone are collectively known as chromones. Most, though not all, chromones are also phenylpropanoid
Phenylpropanoid
The phenylpropanoids are a diverse family of organic compounds that are synthesized by plants from the amino acid phenylalanine. Their name is derived from the six-carbon, aromatic phenyl group and the three-carbon propene tail of cinnamic acid, which is synthesized from phenylalanine in the first...
s.
6,7-dimethoxy-2,3-dihydrochromone has been isolated from Sarcolobus globosus
Sarcolobus globosus
Sarcolobus globosus is a twining shrub native to tropical regions of Asia including India, China, Thailand, Malaysia, Myanmar-Burma, the Philippines and Indonesia....
.
Examples
- Roger Altounyan studied chromones and eventually found disodium cromoglicateCromoglicateCromoglicic acid is traditionally described as a mast cell stabilizer, and is commonly marketed as the sodium salt sodium cromoglicate or cromolyn sodium...
. This drug was found to inhibit antigen challenge as well as stress induced symptoms. Cromoglicate is used as a mast cell stabilizerMast cell stabilizerMast cell stabilizers are cromone medications used to prevent or control certain allergic disorders. They block a calcium channel essential for mast cell degranulation, stabilizing the cell and thereby preventing the release of histamine and related mediators. One suspected pharmacodynamic...
in allergic rhinitisAllergic rhinitisAllergic rhinitis, also known as pollenosis or hay fever, is an allergic inflammation of the nasal airways.It occurs when an allergen, such as pollen, dust or animal dander is inhaled by an individual with a sensitized immune system...
, asthmaAsthmaAsthma is the common chronic inflammatory disease of the airways characterized by variable and recurring symptoms, reversible airflow obstruction, and bronchospasm. Symptoms include wheezing, coughing, chest tightness, and shortness of breath...
and allergic conjunctivitisAllergic conjunctivitisAllergic conjunctivitis is inflammation of the conjunctiva due to allergy. Although allergens differ between patients, the most common cause is hay fever. Symptoms consist of redness , oedema of the conjunctiva, itching and increased lacrimation...
. Comparatively free of side-effects, unfortunately its short half-life limited its value. - NedocromilNedocromilNedocromil sodium is a medication used to prevent wheezing, shortness of breath, and other breathing problems caused by asthma. It is administered by an inhaler under the brand name Tilade and as an eye drop under the brand name Alocril...
sodium was found to have a somewhat longer half-life.