Co-fluampicil
Encyclopedia
Ampicillin
/flucloxacillin
(INNs
) or co-fluampicil (BAN
) is a combination drug of two β-lactam antibiotics, sold under the trade name Magnapen.
whilst flucloxacillin is a narrow spectrum antibiotic with cover against Staphylococcus aureus
. The combination covers the two most likely bacteria in cellulitis
infections in the arm or leg.
family of antibiotics, and therefore should not be taken by patients allergic to penicillin. See flucloxacillin
for additional contraindications.
Ampicillin
Ampicillin is a beta-lactam antibiotic that has been used extensively to treat bacterial infections since 1961. Until the introduction of ampicillin by the British company Beecham, penicillin therapies had only been effective against Gram-positive organisms such as staphylococci and streptococci...
/flucloxacillin
Flucloxacillin
Flucloxacillin or floxacillin is a narrow-spectrum beta-lactam antibiotic of the penicillin class. It is used to treat infections caused by susceptible Gram-positive bacteria. Unlike other penicillins, flucloxacillin has activity against beta-lactamase-producing organisms such as Staphylococcus...
(INNs
International Nonproprietary Name
An International Nonproprietary Name is the official nonproprietary or generic name given to a pharmaceutical substance, as designated by the World Health Organization...
) or co-fluampicil (BAN
British Approved Name
A British Approved Name is the official non-proprietary or generic name given to a pharmaceutical substance, as defined in the British Pharmacopoeia...
) is a combination drug of two β-lactam antibiotics, sold under the trade name Magnapen.
Indication
Ampicillin is a moderate spectrum penicillin antibiotic with good cover against group A streptococcal infectionGroup A streptococcal infection
The group A streptococcus bacterium is a form of β-hemolytic Streptococcus bacteria responsible for most cases of streptococcal illness. Other types may also cause infection...
whilst flucloxacillin is a narrow spectrum antibiotic with cover against Staphylococcus aureus
Staphylococcus aureus
Staphylococcus aureus is a facultative anaerobic Gram-positive coccal bacterium. It is frequently found as part of the normal skin flora on the skin and nasal passages. It is estimated that 20% of the human population are long-term carriers of S. aureus. S. aureus is the most common species of...
. The combination covers the two most likely bacteria in cellulitis
Cellulitis
Cellulitis is a diffuse inflammation of connective tissue with severe inflammation of dermal and subcutaneous layers of the skin. Cellulitis can be caused by normal skin flora or by exogenous bacteria, and often occurs where the skin has previously been broken: cracks in the skin, cuts, blisters,...
infections in the arm or leg.
Formulations
Capsules contain 250 mg of each component, the syrup 125/125 mg per spoon, and the powder for reconstruction for intravenous injection 250/250 mg.Side effects and contraindications
As per the individual components with stomach or bowel upset from the flucloxacillin being the most common. Both parts are members of the penicillinPenicillin
Penicillin is a group of antibiotics derived from Penicillium fungi. They include penicillin G, procaine penicillin, benzathine penicillin, and penicillin V....
family of antibiotics, and therefore should not be taken by patients allergic to penicillin. See flucloxacillin
Flucloxacillin
Flucloxacillin or floxacillin is a narrow-spectrum beta-lactam antibiotic of the penicillin class. It is used to treat infections caused by susceptible Gram-positive bacteria. Unlike other penicillins, flucloxacillin has activity against beta-lactamase-producing organisms such as Staphylococcus...
for additional contraindications.