Complement receptor
Encyclopedia
A complement receptor is a receptor
of the complement system
, a part of the mediated innate immune system
. Complement receptors are responsible for detecting pathogen
s by mechanisms not mediated by antibodies
. Complement activity is not antigen sensitive, but can be triggered by specific antigens. Therefore complement (a group of proteins in the serum that help achieve phagocytosis and lysis of antigens) is also part of the humoral immune system.
Receptor (biochemistry)
In biochemistry, a receptor is a molecule found on the surface of a cell, which receives specific chemical signals from neighbouring cells or the wider environment within an organism...
of the complement system
Complement system
The complement system helps or “complements” the ability of antibodies and phagocytic cells to clear pathogens from an organism. It is part of the immune system called the innate immune system that is not adaptable and does not change over the course of an individual's lifetime...
, a part of the mediated innate immune system
Innate immune system
The innate immune system, also known as non-specific immune system and secondary line of defence, comprises the cells and mechanisms that defend the host from infection by other organisms in a non-specific manner...
. Complement receptors are responsible for detecting pathogen
Pathogen
A pathogen gignomai "I give birth to") or infectious agent — colloquially, a germ — is a microbe or microorganism such as a virus, bacterium, prion, or fungus that causes disease in its animal or plant host...
s by mechanisms not mediated by antibodies
Antibody
An antibody, also known as an immunoglobulin, is a large Y-shaped protein used by the immune system to identify and neutralize foreign objects such as bacteria and viruses. The antibody recognizes a unique part of the foreign target, termed an antigen...
. Complement activity is not antigen sensitive, but can be triggered by specific antigens. Therefore complement (a group of proteins in the serum that help achieve phagocytosis and lysis of antigens) is also part of the humoral immune system.
Complement receptors
Types include:| CR # | Name | CD Cluster of differentiation The cluster of differentiation is a protocol used for the identification and investigation of cell surface molecules present on white blood cells, providing targets for immunophenotyping of cells... >- | CR1 Complement receptor 1 Erythrocyte complement receptor 1 is a human gene.... |
- | >- | - | >- | Macrophage-1 antigen Macrophage-1 antigen Macrophage-1 antigen is a complement receptor consisting of CD11b and CD18.It binds to C3b and C4b.-Function:... or "integrin alphaMbeta2" |
CD18 CD18 Integrin beta-2 is a protein that in humans is encoded by the ITGB2 gene.It is the beta subunit of four different structures:* LFA-1 * Macrophage-1 antigen * Integrin alphaXbeta2... >- | CR4 |
Integrin alphaXbeta2 Integrin alphaXbeta2 Integrin alphaXbeta2 is a complement receptor composed of CD11c and CD18.... or "p150,95" |
CD11c CD11c CD11c, also known as Integrin, alpha X , is a human gene.CD11c is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst;... +CD18 CD18 Integrin beta-2 is a protein that in humans is encoded by the ITGB2 gene.It is the beta subunit of four different structures:* LFA-1 * Macrophage-1 antigen * Integrin alphaXbeta2... >- | - |
C3a receptor | >- | C5a receptor C5a receptor The C5a receptor also known as complement component 5a receptor 1 or CD88 is a G protein-coupled receptor for C5a... |
CD88 |