Connecticut Agricultural Experiment Station
Encyclopedia
The Connecticut Agricultural Experiment Station (CAES) is the Connecticut
Connecticut
Connecticut is a state in the New England region of the northeastern United States. It is bordered by Rhode Island to the east, Massachusetts to the north, and the state of New York to the west and the south .Connecticut is named for the Connecticut River, the major U.S. river that approximately...

 state government's agricultural experiment station
Agricultural experiment station
An agricultural experiment station is a research center that conducts scientific investigations to solve problems and suggest improvements in the food and agriculture industry...

, a state government component that engages in scientific research and public outreach in agriculture
Agriculture
Agriculture is the cultivation of animals, plants, fungi and other life forms for food, fiber, and other products used to sustain life. Agriculture was the key implement in the rise of sedentary human civilization, whereby farming of domesticated species created food surpluses that nurtured the...

 and related fields. It is the oldest state experiment station in the United States, having been founded in 1875. Its official mission is to "develop, advance, and disseminate scientific knowledge, improve agricultural productivity and environmental quality, protect plants, and enhance human health and well-being through research for the benefit of Connecticut residents and the nation." The station operates a main research campus in New Haven
New Haven, Connecticut
New Haven is the second-largest city in Connecticut and the sixth-largest in New England. According to the 2010 Census, New Haven's population increased by 5.0% between 2000 and 2010, a rate higher than that of the State of Connecticut, and higher than that of the state's five largest cities, and...

, a research farm in Hamden
Hamden, Connecticut
Hamden is a town in New Haven County, Connecticut, United States. The town's nickname is "The Land of the Sleeping Giant." Hamden is home to Quinnipiac University. The population was 58,180 according to the Census Bureau's 2005 estimates...

, a satellite research facility and farm in Windsor
Windsor, Connecticut
Windsor is a town in Hartford County, Connecticut, United States, and was the first English settlement in the state. It lies on the northern border of Connecticut's capital, Hartford. The population was estimated at 28,778 in 2005....

, and a research farm in Griswold
Griswold, Connecticut
Griswold is a town in New London County, Connecticut, United States. The population was 10,807 at the 2000 census. Griswold contains one borough, Jewett City, and also contains the villages of Doaneville,Rixtown, Glasgo, Hopeville, and Pachaug...

.

Historic campus in New Haven

The experiment station's main facility in the Prospect Hill area
Prospect Hill (New Haven)
Prospect Hill is a neighborhood of the city of New Haven, Connecticut located in the north central portion of the city, directly north of Downtown New Haven. The neighborhood contains residences, institutional buildings of Albertus Magnus University and a portion of the main campus of Yale...

 of New Haven
New Haven, Connecticut
New Haven is the second-largest city in Connecticut and the sixth-largest in New England. According to the 2010 Census, New Haven's population increased by 5.0% between 2000 and 2010, a rate higher than that of the State of Connecticut, and higher than that of the state's five largest cities, and...

 dates from 1882 when it became the permanent home of the first state agricultural experiment station. The station had been founded at Wesleyan University
Wesleyan University
Wesleyan University is a private liberal arts college founded in 1831 and located in Middletown, Connecticut. According to the Carnegie Foundation for the Advancement of Teaching, Wesleyan is the only Baccalaureate College in the nation that emphasizes undergraduate instruction in the arts and...

 in 1875 and moved to Yale
YALE
RapidMiner, formerly YALE , is an environment for machine learning, data mining, text mining, predictive analytics, and business analytics. It is used for research, education, training, rapid prototyping, application development, and industrial applications...

 in 1877 as it became associated with the Sheffield Scientific School
Sheffield Scientific School
Sheffield Scientific School was founded in 1847 as a school of Yale College in New Haven, Connecticut for instruction in science and engineering. Originally named the Yale Scientific School, it was renamed in 1861 in honor of Joseph E. Sheffield, the railroad executive. The school was...

.

However, by 1882, the station needed more space, and Sheffield needed its space back. A 5 acres (20,234.3 m²) property at the top of Prospect Hill was purchased and buildings built, using a $25,000 appropriation from the state legislature. The buildings include the Osborne Library, built in 1882-83 and believed to be the oldest building at any state agricultural experimental station, and the Johnson Laboratory, which has notably large brackets supporting its wide overhanging eaves.

The station was declared a National Historic Landmark
National Historic Landmark
A National Historic Landmark is a building, site, structure, object, or district, that is officially recognized by the United States government for its historical significance...

 in 1964.

The main campus in New Haven currently houses the activities of six departments: Analytical Chemistry, Biochemistry and Genetics, Entomology, Environmental Sciences, Forestry and Horticulture and Plant Pathology and Ecology.

Analytical Chemistry

The founding department of the Station, Analytical Chemistry began its work in 1875 testing fertilizer
Fertilizer
Fertilizer is any organic or inorganic material of natural or synthetic origin that is added to a soil to supply one or more plant nutrients essential to the growth of plants. A recent assessment found that about 40 to 60% of crop yields are attributable to commercial fertilizer use...

 and later seeds, animal feed, human foods, drugs, and pesticides. This work continues today, and is organized into two categories: food safety and environmental monitoring. The department works with State and Federal agencies to improve pesticide and toxin screening of food sold in Connecticut. The department also has the capability to test for environmental contaminants and toxins in toys and other consumer products at very low concentrations. They test soils for heavy metals
Heavy metals
A heavy metal is a member of a loosely-defined subset of elements that exhibit metallic properties. It mainly includes the transition metals, some metalloids, lanthanides, and actinides. Many different definitions have been proposed—some based on density, some on atomic number or atomic weight,...

, and are investigating the cycling of organic pollutants in the environment, with an emphasis on phytoremediation issues. Additional investigations on the impact of nanoparticles on agricultural crops and on the potential contamination of the food chain are also being undertaken. Work has also been conducted in collaboration with Biochemistry and Genetics as well as colleagues from the Valley Laboratory to investigate which seed crops are best suited for the production of biodiesel
Biodiesel
Biodiesel refers to a vegetable oil- or animal fat-based diesel fuel consisting of long-chain alkyl esters. Biodiesel is typically made by chemically reacting lipids with an alcohol....

 in Connecticut. Recently, the department has been working with the US FDA on the testing of seafood from the Gulf of Mexico
Gulf of Mexico
The Gulf of Mexico is a partially landlocked ocean basin largely surrounded by the North American continent and the island of Cuba. It is bounded on the northeast, north and northwest by the Gulf Coast of the United States, on the southwest and south by Mexico, and on the southeast by Cuba. In...

 for chemical by-products of the Deepwater Horizon
Deepwater Horizon
Deepwater Horizon was an ultra-deepwater, dynamically positioned, semi-submersible offshore oil drilling rig owned by Transocean. Built in 2001 in South Korea by Hyundai Heavy Industries, the rig was commissioned by R&B Falcon, which later became part of Transocean, registered in Majuro, Marshall...

 oil spill.

Biochemistry and genetics

Biochemistry research began at the station in 1888 with the appointment of Thomas B. Osborne and Samuel W. Johnson to study plant proteins. Today, the department focuses largely on plant genetics
Genetics
Genetics , a discipline of biology, is the science of genes, heredity, and variation in living organisms....

 to identify and clone beneficial plant genes to improve crop species. Recent work includes the control of soil-borne pests by cloning
Cloning
Cloning in biology is the process of producing similar populations of genetically identical individuals that occurs in nature when organisms such as bacteria, insects or plants reproduce asexually. Cloning in biotechnology refers to processes used to create copies of DNA fragments , cells , or...

 genes from plants in the mustard family (Brassicaceae
Brassicaceae
Brassicaceae, a medium sized and economically important family of flowering plants , are informally known as the mustards, mustard flowers, the crucifers or the cabbage family....

) that enable plants to protect their roots from nematodes. Work is also conducted on elucidating the genetic basis for photosynthetic performance in plant leaves (10). Furthermore, the department helps protect honeybee colonies by developing early-detection tests for American Foulbrood(AFB) disease, and establish protocols to control the causal bacterium.

Entomology

The department is continuing its pioneering research on Lyme disease
Lyme disease
Lyme disease, or Lyme borreliosis, is an emerging infectious disease caused by at least three species of bacteria belonging to the genus Borrelia. Borrelia burgdorferi sensu stricto is the main cause of Lyme disease in the United States, whereas Borrelia afzelii and Borrelia garinii cause most...

 and its vector in Connecticut, the blacklegged tick (Ixodes scapularis
Ixodes scapularis
Ixodes scapularis is commonly known as the deer tick or blacklegged tick , and in some parts of the USA as the bear tick. It is a hard-bodied tick of the eastern and northern Midwestern United States...

); biological control of ticks using the fungus
Fungus
A fungus is a member of a large group of eukaryotic organisms that includes microorganisms such as yeasts and molds , as well as the more familiar mushrooms. These organisms are classified as a kingdom, Fungi, which is separate from plants, animals, and bacteria...

, Metarhizium
Metarhizium
Metarhizium is a genus of entomopathogenic fungi in the Clavicipitaceae family. With the advent of genetic profiling, it has now become possible to place these fungi in proper taxa. Most turn out to be the asexual forms of fungi in the phylum Ascomycota.- Species :Nine distinct species have now...

 anisopliae; and has developed new testing methods for tick-borne illnesses in humans, wildlife and domesticated animals. Every year, thousands of ticks are sent in from around the state to be tested for disease agents. The department also conducts research on the biology and control of exotic insects, including the invasive Asian long-horned beetle
Asian long-horned beetle
The Asian long-horned beetle known as the starry sky or sky beetle is native to eastern China, Japan, and Korea. This species has now been accidentally introduced to the United States, where it was first discovered in 1996, as well as Canada and several countries in Europe, including Austria,...

 and emerald ash borer
Emerald ash borer
The emerald ash borer is a green beetle native to Asia.In North America the borer is an invasive species, highly destructive to ash trees in its introduced range. The potential damage of this insect rivals that of Chestnut blight and Dutch Elm Disease...

, looking at the chemistry of tree selection and mating behavior. The Entomology department supports agricultural production in Connecticut with integrated pest management
Integrated Pest Management
Integrated pest management is an ecological approach to agricultural pest control that integrates pesticides/herbicides into a management system incorporating a range of practices for economic control of a pest...

 (IPM) efforts, helping reduce pesticide
Pesticide
Pesticides are substances or mixture of substances intended for preventing, destroying, repelling or mitigating any pest.A pesticide may be a chemical unicycle, biological agent , antimicrobial, disinfectant or device used against any pest...

 use.

Environmental Sciences

The Experiment Station has conducted research on mosquitoes and the diseases they carry since 1909. This work is carried on today within the Environmental Sciences Department (formerly “Soil and Water”). Mosquitoes are collected from around the state of Connecticut then tested for West Nile virus
West Nile virus
West Nile virus is a virus of the family Flaviviridae. Part of the Japanese encephalitis antigenic complex of viruses, it is found in both tropical and temperate regions. It mainly infects birds, but is known to infect humans, horses, dogs, cats, bats, chipmunks, skunks, squirrels, domestic...

, eastern equine encephalitis and other disease-causing agents. Researchers have also undertaken an effort to map the distribution of invasive aquatic plants within the state and investigate methods to control their growth and spread. Scientists are also conducting research on Phytoremediation
Phytoremediation
Phytoremediation Phytoremediation Phytoremediation (from the Ancient Greek , and Latin (restoring balance or remediation) describes the treatment of environmental problems (bioremediation) through the use of plants that mitigate the environmental problem without the need to excavate the...

, which focuses on the ability of certain cucurbit
Cucurbit
Cucurbit may refer to:*A plant of the family Cucurbitaceae*The lower part of an alembic*Cucurbit flute, Chinese musical instrument...

 species to remove persistent organic pollutants (POPs) such as PCBs and DDT
DDT
DDT is one of the most well-known synthetic insecticides. It is a chemical with a long, unique, and controversial history....

 from soil. The department also tests soil samples sent in by Connecticut businesses and residents.

Forestry and horticulture

New crops suited to Connecticut (such as Chinese cabbage
Chinese cabbage
Chinese cabbage can refer to two distinct varieties of Chinese leaf vegetables used often in Chinese cuisine. These vegetables are both related to the Western cabbage, and are of the same species as the common turnip...

, calabaza
Calabaza
Calabaza is a term that can be applied to a variety of gourds and melons grown throughout the world.-Etymology :The word calabaza is derived from the Persian term for melon . The French term "calabasse", and hence "calabash" is based on the older Spanish...

, and heirloom
Heirloom
In popular usage, an heirloom is something, perhaps an antique or some kind of jewelry, that has been passed down for generations through family members....

 tomatoes as well as cultivar
Cultivar
A cultivar'Cultivar has two meanings as explained under Formal definition. When used in reference to a taxon, the word does not apply to an individual plant but to all those plants sharing the unique characteristics that define the cultivar. is a plant or group of plants selected for desirable...

s of wine grapes and different viticulture
Viticulture
Viticulture is the science, production and study of grapes which deals with the series of events that occur in the vineyard. When the grapes are used for winemaking, it is also known as viniculture...

 methods are being investigated. Scientists have also studied white-tailed deer (Odocoileus virginianus) behavior in hopes of keeping these animals away from highways to prevent vehicle-deer collisions, and to reduce damage to tree saplings, crops, and gardens. The department has surveyed certain forest plots every decade since 1907 (with the exception of 1947), providing information about how forests change over long periods of time. Researchers have also investigated techniques for crop-tree management that both increases yields and improves forest health. Department scientists are currently investigating the association of Japanese barberry (an invasive shrub), white-footed mice, and Ixodes
Ixodes
Ixodes is a genus of hard-bodied ticks . It includes important disease vectors of animals and humans . Some ticks in this genus may transmit the pathogenic bacterium Borrelia burgdorferi responsible for causing Lyme disease...

 ticks that carry the Lyme disease
Lyme disease
Lyme disease, or Lyme borreliosis, is an emerging infectious disease caused by at least three species of bacteria belonging to the genus Borrelia. Borrelia burgdorferi sensu stricto is the main cause of Lyme disease in the United States, whereas Borrelia afzelii and Borrelia garinii cause most...

 organism and other human pathogens in the state’s forests, and cost-effective means to control invasive plant species.

Plant pathology and ecology

The plant pathology
Pathology
Pathology is the precise study and diagnosis of disease. The word pathology is from Ancient Greek , pathos, "feeling, suffering"; and , -logia, "the study of". Pathologization, to pathologize, refers to the process of defining a condition or behavior as pathological, e.g. pathological gambling....

 and ecology
Ecology
Ecology is the scientific study of the relations that living organisms have with respect to each other and their natural environment. Variables of interest to ecologists include the composition, distribution, amount , number, and changing states of organisms within and among ecosystems...

 department works to expand knowledge of ecological interactions of plants, pathogens, and their environment to develop management strategies for plant pathogens with minimal use of pesticides. Current research includes investigating the causes of Sudden Vegetation Dieback of coastal salt marsh
Salt marsh
A salt marsh is an environment in the upper coastal intertidal zone between land and salt water or brackish water, it is dominated by dense stands of halophytic plants such as herbs, grasses, or low shrubs. These plants are terrestrial in origin and are essential to the stability of the salt marsh...

es; breeding blight
Blight
Blight refers to a specific symptom affecting plants in response to infection by a pathogenic organism. It is simply a rapid and complete chlorosis, browning, then death of plant tissues such as leaves, branches, twigs, or floral organs. Accordingly, many diseases that primarily exhibit this...

-resistant American chestnut
American Chestnut
The American Chestnut is a large, deciduous tree of the beech family native to eastern North America. Before the species was devastated by the chestnut blight, a fungal disease, it was one of the most important forest trees throughout its range...

 trees for timber and nut production; modeling epidemics of powdery mildew of grapevines, and investigating the genetic
Genetics
Genetics , a discipline of biology, is the science of genes, heredity, and variation in living organisms....

 structure in natural populations of a fungus
Fungus
A fungus is a member of a large group of eukaryotic organisms that includes microorganisms such as yeasts and molds , as well as the more familiar mushrooms. These organisms are classified as a kingdom, Fungi, which is separate from plants, animals, and bacteria...

 causing perennial cankers of birch
Birch
Birch is a tree or shrub of the genus Betula , in the family Betulaceae, closely related to the beech/oak family, Fagaceae. The Betula genus contains 30–60 known taxa...

. The department is also the official seed testing laboratory for the state of Connecticut.

Valley Laboratory

Previously referred to as the “Tobacco Substation,” the Valley Laboratory in Windsor, CT has a long history of improving the cultivation of tobacco
Tobacco
Tobacco is an agricultural product processed from the leaves of plants in the genus Nicotiana. It can be consumed, used as a pesticide and, in the form of nicotine tartrate, used in some medicines...

 leaves in Connecticut for use as fine cigar
Cigar
A cigar is a tightly-rolled bundle of dried and fermented tobacco that is ignited so that its smoke may be drawn into the mouth. Cigar tobacco is grown in significant quantities in Brazil, Cameroon, Cuba, the Dominican Republic, Honduras, Indonesia, Mexico, Nicaragua, Philippines, and the Eastern...

 wrappers. The “Tobacco Laboratory,” (now simply the Valley Laboratory) building was completed in 1941. Today, research covers areas such as the production of biofuel
Biofuel
Biofuel is a type of fuel whose energy is derived from biological carbon fixation. Biofuels include fuels derived from biomass conversion, as well as solid biomass, liquid fuels and various biogases...

 crops, invasive plant management,developing integrated pest management
Integrated Pest Management
Integrated pest management is an ecological approach to agricultural pest control that integrates pesticides/herbicides into a management system incorporating a range of practices for economic control of a pest...

 (IPM) methods for Connecticut nurseries, and management of the exotic hemlock woolly adelgid (Adelges tsugae).

Lockwood Farm

The research farm is named after William Raymond Lockwood. He was a resident of Norwalk, CT who willed his estate to CAES, proceeds from the sale of which went towards the purchase of 20 acres of land in the Mount Carmel
Mount Carmel
Mount Carmel ; , Kármēlos; , Kurmul or جبل مار إلياس Jabal Mar Elyas 'Mount Saint Elias') is a coastal mountain range in northern Israel stretching from the Mediterranean Sea towards the southeast. Archaeologists have discovered ancient wine and oil presses at various locations on Mt. Carmel...

 area of Hamden, CT in 1909(12). During the mid-twentieth century, James G. Horsfall (former Station Director) used the farm to test organically-derived fungicides as a replacement for the heavy metals
Heavy metals
A heavy metal is a member of a loosely-defined subset of elements that exhibit metallic properties. It mainly includes the transition metals, some metalloids, lanthanides, and actinides. Many different definitions have been proposed—some based on density, some on atomic number or atomic weight,...

 used to treat plant diseases at the time. Since 1931, the farm managers have taken daily, systematic weather measurements which provide information that can be used to study Connecticut’s climate
Climate
Climate encompasses the statistics of temperature, humidity, atmospheric pressure, wind, rainfall, atmospheric particle count and other meteorological elemental measurements in a given region over long periods...

. Many plant varieties and growing methods are tested. Every year in August the farm hosts the annual Plant Science Day.

Griswold Research Center

The most recent addition to the CT Agricultural Experiment Station’s holdings, Griswold Research Center, encompasses 14 acres of farmland in Griswold, CT and an additional parcel of forest in the adjacent town of Voluntown, CT. Transferred from the Connecticut Department of Environmental Protection
Connecticut Department of Environmental Protection
The Connecticut Department of Energy and Environmental Protection is a state agency of Connecticut. The department oversees the natural resources and environment of the state, as well as regulating public utilities and energy policy...

 (DEP) in 2008, current activities on the property include studies of cold-hardy grape
Grape
A grape is a non-climacteric fruit, specifically a berry, that grows on the perennial and deciduous woody vines of the genus Vitis. Grapes can be eaten raw or they can be used for making jam, juice, jelly, vinegar, wine, grape seed extracts, raisins, molasses and grape seed oil. Grapes are also...

 vine varieties, the cultivation of rapeseed
Rapeseed
Rapeseed , also known as rape, oilseed rape, rapa, rappi, rapaseed is a bright yellow flowering member of the family Brassicaceae...

 for biofuel production and the biocontrol of soil nematodes. There is also an office for the State Bee Inspector, who monitors Connecticut’s honeybee populations.

Station directors

The station has had just eight directors during its history:
  • Dr. Wilbur Olin Atwater
    Wilbur Olin Atwater
    Wilbur Olin Atwater was an American chemist known for his studies of human nutrition and metabolism....

     (1875–1877)
  • Dr. Samuel W. Johnson (1877–1900)
  • Dr. Edward H. Jenkins (1900–1922)
  • Dr. William L. Slate (1923–1947)
  • Dr. James G. Horsfall (1948–1971)
  • Dr. Paul E. Waggoner (1972–1987)
  • Dr. John F. Anderson (1987–2004)
  • Dr. Louis A. Magnarelli (2004–Present)

Amino acids and the discovery of vitamins


In 1909 station chemist Thomas B. Osborne began collaborating with Lafayette Mendel
Lafayette Mendel
Lafayette Benedict Mendel was an American biochemist known for his work in nutrition including the study of Vitamin A, Vitamin B, lysine and tryptophan....

 of Yale University
Yale University
Yale University is a private, Ivy League university located in New Haven, Connecticut, United States. Founded in 1701 in the Colony of Connecticut, the university is the third-oldest institution of higher education in the United States...

 to test the nutritive value of the proteins that Osborne had isolated from crop seeds.

Through feeding trials with albino rats, they determined that the type and quality of protein
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 actually was more important to growth than quantity. They found that certain amino acids were lacking in the proteins isolated from grains. For example, when rats were given only zein
Zein
Zein is a class of prolamine protein found in maize. It is usually manufactured as a powder from corn gluten meal.-Commercial uses:Zein is one of the best understood plant proteins and has a variety of industrial and food uses...

, found in corn, as their protein source in an otherwise complete diet, their health declined and they died. This occurred because zein lacks the essential amino acids lysine
Lysine
Lysine is an α-amino acid with the chemical formula HO2CCH4NH2. It is an essential amino acid, which means that the human body cannot synthesize it. Its codons are AAA and AAG....

 and tryptophan
Tryptophan
Tryptophan is one of the 20 standard amino acids, as well as an essential amino acid in the human diet. It is encoded in the standard genetic code as the codon UGG...

. When the researchers added tryptophan to the isolated zein, rats were able to survive but did not grow. When both tryptophan and lysine were added, the rats both survived and grew rapidly. Osborne and Mendel also found that the gliadin
Gliadin
Gliadin is a glycoprotein present in wheat and several other cereals within the grass genus Triticum. Gliadins are prolamins and are separated on the basis of electrophoretic mobility and isoelectric focusing.- Types :...

, the protein found in wheat was lacking certain amino acids, and that like corn, these deficiencies could be amended by combining grain foods with animal proteins such as eggs or milk. This experiment demonstrated that animals need to acquire certain amino acids from food, which are now referred to as the essential amino acids.

In their study of proteins, Osborne and Mendel also aided in the discovery of vitamins. During their feeding trials, they noticed that young rats fed diets with sufficient carbohydrate
Carbohydrate
A carbohydrate is an organic compound with the empirical formula ; that is, consists only of carbon, hydrogen, and oxygen, with a hydrogen:oxygen atom ratio of 2:1 . However, there are exceptions to this. One common example would be deoxyribose, a component of DNA, which has the empirical...

 (in the form of wheat flour) and purified protein, but with vegetable fats or lard
Lard
Lard is pig fat in both its rendered and unrendered forms. Lard was commonly used in many cuisines as a cooking fat or shortening, or as a spread similar to butter. Its use in contemporary cuisine has diminished because of health concerns posed by its saturated-fat content and its often negative...

 instead of butter
Butter
Butter is a dairy product made by churning fresh or fermented cream or milk. It is generally used as a spread and a condiment, as well as in cooking applications, such as baking, sauce making, and pan frying...

 grew and developed normally for around eighty days, then suddenly began to decline in health and weight then soon died. Many of the animals also developed sore eyes or even ulcers on their eyeballs. Something other than carbohydrates, fats and complete proteins was missing from this artificial diet. When a small amount of butter was added to the feed mixture, the afflicted rats soon recovered completely and continued growing. Whole-milk powder also had the same effect on rat growth. In 1913, the Station’s Annual Report stated that “experiments have shown that some still unknown substance is essential to growth and that this unknown substance is present in milk. Much work is being done in an effort to discover an isolate this substance.” As it turns out, this substance was Vitamin A
Vitamin A
Vitamin A is a vitamin that is needed by the retina of the eye in the form of a specific metabolite, the light-absorbing molecule retinal, that is necessary for both low-light and color vision...

. Concurrently with Osborne and Mendel, Elmer V. McCollum (a former student of Osborne) and Marguerite Davis at the University of Wisconsin were obtaining similar results, and although the scientists submitted their report for publication several weeks prior to the Station scientists, it is clear that both parties discovered vitamins independently.

Development of hybrid corn

In the early 20th century, Station scientists Edward M. East and Herbert K. Hayes began attempts to improve the quality and yield of corn (Zea mays) through selective breeding and hybridization. In 1906, East realized that steps to prevent self- and close-fertilization made it easier to select for desirable traits (such as large ear size) when breeding. Hayes and East later found described that a cross, or hybrid, between two inbred varieties of corn produced offspring that was more vigorous, larger and hardier that both of the parents, but this improvement was lost over successive inbred generations.

In 1914, Donald F. Jones
Donald F. Jones
Donald Forsha Jones was a United States maize geneticist and practical corn breeder at the Connecticut Agricultural Experiment Station, New Haven. Beginning at the station in 1914, he made high-yielding hybrid corn practical by his invention of the double-cross hybrid.In Jones' method, four...

 arrived at the station at the age of twenty-five, and began to build upon on the work of East and Hayes. By 1917, he had published his theory of “heterosis
Heterosis
Heterosis, or hybrid vigor, or outbreeding enhancement, is the improved or increased function of any biological quality in a hybrid offspring. The adjective derived from heterosis is heterotic....

,” which explained the increased vigor and yield observed in hybrid maize
Maize
Maize known in many English-speaking countries as corn or mielie/mealie, is a grain domesticated by indigenous peoples in Mesoamerica in prehistoric times. The leafy stalk produces ears which contain seeds called kernels. Though technically a grain, maize kernels are used in cooking as a vegetable...

. The same year, he created a double-cross hybrid corn by breeding two separate hybrid individuals. This new cross descended from four distinct inbred lines, and was even more vigorous than either of its parents. However, like the single-cross hybrid, this improvement was lost over subsequent generations of inbreeding. Jones published his double-cross method in 1919, and began actively promoting the technique as a means to improve corn production nationally: “it is something that may easily be taken up by seedsmen; in fact, it is the first time in agricultural history that a seedsman is enabled to gain full benefit from a desirable origination of his own… The utilization of first generation hybrids enables to originator to keep the parental types and give out only the crossed seeds, which are less valuable for continued propagation.”

Because corn is a self-fertilizing plant, the prevention of inbreeding when producing hybrid seeds required time-consuming detasseling
Detasseling
Detasseling corn is removing the pollen-producing flowers, the tassel, from the tops of corn plants and placing them on the ground. It is a form of pollination control, employed to cross-breed, or hybridize, two varieties of corn....

. In the 1940s and 50’s, Jones collaborated with Paul Mangelsdorf of Harvard University
Harvard University
Harvard University is a private Ivy League university located in Cambridge, Massachusetts, United States, established in 1636 by the Massachusetts legislature. Harvard is the oldest institution of higher learning in the United States and the first corporation chartered in the country...

 to eliminate the need to remove the tassels from plants in seed production through utilizing a sterile plant and male restorer gene, making the production of corn more cost-efficient.

"Morgan" method of soil testing

Dr. M. F. Morgan, Chief of Soils Department for twenty years, developed a method that still bears his name to test for soil nutrients that are available to plants using weak acids. This test was able to estimate deficiencies or excesses of plant nutrients in soil. Dr. Morgan was also a Lieutenant Colonel in the U.S. Army during World War II, and was killed in action on the Leyte Island
Leyte Island
Leyte is an island in the Visayas group of the Philippines.The island measures about 180 km north-south and about 65 km at its widest point. In the north it nearly joins Samar, separated by the San Juanico Strait, which becomes as narrow as 2 km in some places...

 in the Philippines
Philippines
The Philippines , officially known as the Republic of the Philippines , is a country in Southeast Asia in the western Pacific Ocean. To its north across the Luzon Strait lies Taiwan. West across the South China Sea sits Vietnam...

 in 1945.

Morgan's soil test became the world’s first widely accepted method for efficiently estimating soil fertility, and is still in use today.

Tick-borne diseases

In 1975, there was a cluster of juvenile arthritis
Arthritis
Arthritis is a form of joint disorder that involves inflammation of one or more joints....

 patients in the towns of Lyme and Old Lyme, CT, and scientists at the Station were among the first to determine that this disease was carried by ticks. After this discovery, scientists at the Station, including John F. Anderson and Louis A. Magnarelli (former and current Station Directors, respectively) along with collaborators from other institutions were able to isolate and identify the spirochete that causes Lyme disease
Lyme disease
Lyme disease, or Lyme borreliosis, is an emerging infectious disease caused by at least three species of bacteria belonging to the genus Borrelia. Borrelia burgdorferi sensu stricto is the main cause of Lyme disease in the United States, whereas Borrelia afzelii and Borrelia garinii cause most...

 in humans. Scientists at the Station were also instrumental in developing antibody
Antibody
An antibody, also known as an immunoglobulin, is a large Y-shaped protein used by the immune system to identify and neutralize foreign objects such as bacteria and viruses. The antibody recognizes a unique part of the foreign target, termed an antigen...

 tests to identify patients infected with Lyme disease agent as well as other tick-borne illnesses such as human granulocytic erlichiosis and babeosis.

Timeline of significant events

1875: The Connecticut Agricultural Experiment Station is established; the first in the United States, and precursor for the nation’s industrial research laboratories; founded twenty-five years prior to the General Electric laboratories, which was the first of its kind.

1882: The Station moves to its current location on Huntington Street in New Haven, land purchased from the Eli Whitney
Eli Whitney
Eli Whitney was an American inventor best known for inventing the cotton gin. This was one of the key inventions of the Industrial Revolution and shaped the economy of the Antebellum South...

, Jr. family

1890: Dr. Roland Thaxter, botanist at the Station, determines the cause of potato scab (an actinomycete that infects tubers).

1900: Sumatran tobacco was planted under cloth canopies in Connecticut in an effort to simulate Sumatra’s tropical climate. The resulting shade grown tobacco was considered second to none for making cigar wrappers and consequently revolutionized the industry in the Connecticut Valley.

1903: State entomologist William E. Britton and G. P. Clinton issue the first pesticide
Pesticide
Pesticides are substances or mixture of substances intended for preventing, destroying, repelling or mitigating any pest.A pesticide may be a chemical unicycle, biological agent , antimicrobial, disinfectant or device used against any pest...

 “spray
calendar” to be used by Connecticut farmers.

1905: The first gypsy moth
Gypsy moth
The gypsy moth, Lymantria dispar, is a moth in the family Lymantriidae of Eurasian origin. Originally ranging from Europe to Asia, it was introduced to North America in the late 1860s and has been expanding its range ever since...

 discovered in Connecticut was found in Stonington, CT by E. Frensch of Mystic, CT. A female specimen, collected on July 25, was given to W. E. Britton and is still present in the Station’s insect collection.

1907: Chestnut blight
Chestnut blight
The pathogenic fungus Cryphonectria parasitica is a member of the ascomycota category, and is the main cause of chestnut blight, a devastating disease of the American chestnut tree that caused a mass extinction in the early 1900s of this once plentiful tree from its historic range in the eastern...

 first seen in Connecticut.

1913: Thomas B. Osborne, chemist at the Station, and Lafayette B. Mendel of Yale University
demonstrate with rat feeding studies that animals require twenty essential amino acids in their
diet, and identify a “yellow substance” in butterfat vital for animal growth, which turned out to
be Vitamin A
Vitamin A
Vitamin A is a vitamin that is needed by the retina of the eye in the form of a specific metabolite, the light-absorbing molecule retinal, that is necessary for both low-light and color vision...



1917: The first hybrid corn using a four-way cross made by geneticist Donald F. Jones. He also publishes the theory of “heterosis” to explain hybrid vigor in corn.

1919: Jones invents a double cross pollination
Pollination
Pollination is the process by which pollen is transferred in plants, thereby enabling fertilisation and sexual reproduction. Pollen grains transport the male gametes to where the female gamete are contained within the carpel; in gymnosperms the pollen is directly applied to the ovule itself...

 method, which allows for commercial production of hybrid corn.

1921: The Valley Laboratory established in Windsor, CT (called Tobacco Substation at the time).

1933: Dutch elm disease
Dutch elm disease
Dutch elm disease is a disease caused by a member of the sac fungi category, affecting elm trees which is spread by the elm bark beetle. Although believed to be originally native to Asia, the disease has been accidentally introduced into America and Europe, where it has devastated native...

 was found in extreme southwestern Connecticut.

1938: First report of X-disease of peach
Peach
The peach tree is a deciduous tree growing to tall and 6 in. in diameter, belonging to the subfamily Prunoideae of the family Rosaceae. It bears an edible juicy fruit called a peach...

 in the U.S. by E. M. Stoddard

1942: Dr. M. F. Morgan, developer of the Morgan method of soil testing and Chief of the Soils Department, was killed in action in the Philippines
Philippines
The Philippines , officially known as the Republic of the Philippines , is a country in Southeast Asia in the western Pacific Ocean. To its north across the Luzon Strait lies Taiwan. West across the South China Sea sits Vietnam...

 during World War II.

1949: A. E. Dimond developed an injectable chemotherapy to treat Dutch elm disease.

1960: R.C. Wallis of the Station and collaborators isolated a virus
Virus
A virus is a small infectious agent that can replicate only inside the living cells of organisms. Viruses infect all types of organisms, from animals and plants to bacteria and archaea...

 that causes encephalitis
Encephalitis
Encephalitis is an acute inflammation of the brain. Encephalitis with meningitis is known as meningoencephalitis. Symptoms include headache, fever, confusion, drowsiness, and fatigue...

 from Aedes vexans
Aedes vexans
Aedes vexans is a cosmopolitan and common pest mosquito. It is a known vector of Dirofilaria immitis ; Myxomatosis ; and tahyna-virus, a seldom-diagnosed Bunyaviridae, a disease which affects humans in Europe with fever which disappears after two days, but afterward can cause Encephalitis or...

, mosquitoes found in Connecticut.

1969: EPIDEM, the first computer simulation for development of a disease epidemic
Epidemic
In epidemiology, an epidemic , occurs when new cases of a certain disease, in a given human population, and during a given period, substantially exceed what is expected based on recent experience...

, was developed by P. E. Waggoner and J. G. Horsfall for early blight on tomato and potato.

1975: Biological control of chestnut blight
Chestnut blight
The pathogenic fungus Cryphonectria parasitica is a member of the ascomycota category, and is the main cause of chestnut blight, a devastating disease of the American chestnut tree that caused a mass extinction in the early 1900s of this once plentiful tree from its historic range in the eastern...

 was demonstrated using hypovirulence, which was associated with dsRNA transmitted by hyphal anastomosis.

1983: John F. Anderson, Louis A. Magnarelli (Station Director and Deputy Director, respectively, at the time) along with colleagues from Yale University and Centers for Disease Control and Prevention
Centers for Disease Control and Prevention
The Centers for Disease Control and Prevention are a United States federal agency under the Department of Health and Human Services headquartered in Druid Hills, unincorporated DeKalb County, Georgia, in Greater Atlanta...

, are able to isolated the causative agent of Lyme disease
Lyme disease
Lyme disease, or Lyme borreliosis, is an emerging infectious disease caused by at least three species of bacteria belonging to the genus Borrelia. Borrelia burgdorferi sensu stricto is the main cause of Lyme disease in the United States, whereas Borrelia afzelii and Borrelia garinii cause most...

 (the spirochete Borrelia burdorferi) from Ixodes
Ixodes
Ixodes is a genus of hard-bodied ticks . It includes important disease vectors of animals and humans . Some ticks in this genus may transmit the pathogenic bacterium Borrelia burgdorferi responsible for causing Lyme disease...

 ticks, a raccoon
Raccoon
Procyon is a genus of nocturnal mammals, comprising three species commonly known as raccoons, in the family Procyonidae. The most familiar species, the common raccoon , is often known simply as "the" raccoon, as the two other raccoon species in the genus are native only to the tropics and are...

, and a white-footed mouse
White-footed mouse
White-footed Mouse is a rodent native to North America. It ranges from Ontario, Quebec, Labrador and the Maritime Provinces to the southwest USA and Mexico. It is also known as the Woodmouse, particularly in Texas.Adults are in length, not counting the tail, which can add another . A young adult...

.

1989: T.G. Andreadis and R. M. Weseloh discover the fungus
Fungus
A fungus is a member of a large group of eukaryotic organisms that includes microorganisms such as yeasts and molds , as well as the more familiar mushrooms. These organisms are classified as a kingdom, Fungi, which is separate from plants, animals, and bacteria...

 that caused the collapse of gypsy
moth populations.

1994: S. L. Anagnostakis is given the first permit to release a genetically recombinant biocontrol
BioControl
BioControl is a peer-reviewed scientific journal published by Springer Science+Business Media covering all aspects of basic and applied research in biological control of invertebrate, vertebrate, and weed pests, and plant diseases. The journal was established in 1956 as Entomophaga and published by...


agent into a Connecticut forest in an attempt to control chestnut blight disease.

1995: Magnarelli, Anderson and collaborators from Yale University, Johns Hopkins University
Johns Hopkins University
The Johns Hopkins University, commonly referred to as Johns Hopkins, JHU, or simply Hopkins, is a private research university based in Baltimore, Maryland, United States...

, and University of Minnesota
University of Minnesota
The University of Minnesota, Twin Cities is a public research university located in Minneapolis and St. Paul, Minnesota, United States. It is the oldest and largest part of the University of Minnesota system and has the fourth-largest main campus student body in the United States, with 52,557...

 demonstrated that patients with Lyme disease also had antibodies to organisms that cause babesiosis
Babesiosis
Babesiosis is a malaria-like parasitic disease caused by infection with Babesia, a genus of protozoal piroplasms. After trypanosomes, Babesia are thought to be the second most common blood parasites of mammals and they can have a major impact on health of domestic animals in areas without severe...

 and ehrlichiosis
Ehrlichiosis
Ehrlichiosis is a tick-borne disease of dogs usually caused by the organism Ehrlichia canis. Ehrlichia canis is the pathogen of animals. Humans can become infected by E. canis and other species after tick exposure. German Shepherd dogs are thought to be particularly affected by the disease, other...

; Magnarelli, K.C. Stafford and scientists from the Johns Hopkins University and University of Rhode Island detected the DNA of the human granulocytic ehrlichiosis agent in ticks.

2005: The Department of Analytical Chemistry was selected through a competitive process as one of eight state laboratories across the country to receive funding from the United States Food and Drug Administration as a participant in the FERN (Food Emergency Response Network).

2009: The Center for Vector Biology and Zoonotic Diseases is established at the Station. This joint venture between the Entomology and Environmental Sciences Departments aims to better understand the biology of arthropod-borne diseases and the organisms that transmit them.

2010: New methods developed to test seafood from the Gulf of Mexico
Gulf of Mexico
The Gulf of Mexico is a partially landlocked ocean basin largely surrounded by the North American continent and the island of Cuba. It is bounded on the northeast, north and northwest by the Gulf Coast of the United States, on the southwest and south by Mexico, and on the southeast by Cuba. In...

 for contamination with petroleum
Petroleum
Petroleum or crude oil is a naturally occurring, flammable liquid consisting of a complex mixture of hydrocarbons of various molecular weights and other liquid organic compounds, that are found in geologic formations beneath the Earth's surface. Petroleum is recovered mostly through oil drilling...

-related chemicals.

External links

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