Core binding factor
Encyclopedia
The Core binding factor is a group of heterodimeric
transcription factor
s.
Core binding factors are composed of:
Protein dimer
In biochemistry, a dimer is a macromolecular complex formed by two, usually non-covalently bound, macromolecules like proteins or nucleic acids...
transcription factor
Transcription factor
In molecular biology and genetics, a transcription factor is a protein that binds to specific DNA sequences, thereby controlling the flow of genetic information from DNA to mRNA...
s.
Core binding factors are composed of:
- a non-DNADNADeoxyribonucleic acid is a nucleic acid that contains the genetic instructions used in the development and functioning of all known living organisms . The DNA segments that carry this genetic information are called genes, but other DNA sequences have structural purposes, or are involved in...
-binding CBFβ chain (CBFBCBFBCore-binding factor subunit beta is a protein that in humans is encoded by the CBFB gene.-Further reading:...
) - a DNA-binding CBFα chain (RUNX1RUNX1Runt-related transcription factor 1 also known as acute myeloid leukemia 1 protein or core-binding factor subunit alpha-2 is a protein that in humans is encoded by the RUNX1 gene....
, RUNX2Runx2Runt-related transcription factor 2 also known as core-binding factor subunit alpha-1 is a protein that in humans is encoded by the RUNX2 gene RUNX2 is a key transcription factor associated with osteoblast differentiation....
, RUNX3RUNX3Runt-related transcription factor 3 is a protein that in humans is encoded by the RUNX3 gene.- Knockout mouse :Runx3 null mouse gastric mucosa exhibits hyperplasia due to stimulated proliferation and suppressed apoptosis in epithelial cells, and the cells are resistant to TGF-beta...
)