Cyclin-dependent kinase 8
Encyclopedia
Cell division protein kinase 8 is an enzyme
that in humans is encoded by the CDK8 gene
.
with MED16
, MED26
, MED17
, MED14
, CREB binding protein
, MED1
, MED6
, MED24
, CCNC
, POLR2A
, MED21
, SMARCB1
, MED12
and CRSP3
.
Enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
that in humans is encoded by the CDK8 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Interactions
Cyclin-dependent kinase 8 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with MED16
MED16
Mediator of RNA polymerase II transcription subunit 16 is an enzyme that in humans is encoded by the MED16 gene.-Interactions:MED16 has been shown to interact with Thyroid hormone receptor alpha, Estrogen receptor alpha and Cyclin-dependent kinase 8....
, MED26
MED26
Mediator of RNA polymerase II transcription subunit 26 is an enzyme that in humans is encoded by the MED26 gene.-Interactions:MED26 has been shown to interact with MED8, Cyclin-dependent kinase 8, POLR2A, MED12 and MED28.-Further reading:...
, MED17
MED17
Mediator of RNA polymerase II transcription subunit 17 is an enzyme that in humans is encoded by the MED17 gene.-Interactions:MED17 has been shown to interact with PPARGC1A, Cyclin-dependent kinase 8 and BRCA1.-Further reading:...
, MED14
MED14
Mediator of RNA polymerase II transcription subunit 14 is an enzyme that in humans is encoded by the MED14 gene.-Interactions:MED14 has been shown to interact with PPARGC1A, Estrogen receptor alpha, STAT2, Cyclin-dependent kinase 8, Glucocorticoid receptor and Hepatocyte nuclear factor 4...
, CREB binding protein
CREB binding protein
CREB-binding protein, also known as CREBBP or CBP, is a protein that in humans is encoded by the CREBBP gene.The CREB protein carries out its function by activating transcription, where interaction with transcription factors is managed by one or more of p300 domains: the nuclear receptor...
, MED1
MED1
Mediator of RNA polymerase II transcription subunit 1 is a protein that in humans is encoded by the MED1 gene.- Function :The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with...
, MED6
MED6
Mediator of RNA polymerase II transcription subunit 6 is an enzyme that in humans is encoded by the MED6 gene.-Interactions:MED6 has been shown to interact with Thyroid hormone receptor alpha, Estrogen receptor alpha, MED21 and Cyclin-dependent kinase 8.-Further reading:...
, MED24
MED24
Mediator of RNA polymerase II transcription subunit 24 is an enzyme that in humans is encoded by the MED24 gene.-Interactions:MED24 has been shown to interact with Estrogen receptor alpha, Cyclin-dependent kinase 8, Calcitriol receptor and BRCA1....
, CCNC
CCNC (gene)
Cyclin-C is a protein that in humans is encoded by the CCNC gene.-Interactions:CCNC has been shown to interact with Estrogen receptor alpha and Cyclin-dependent kinase 8.-Further reading:...
, POLR2A
POLR2A
DNA-directed RNA polymerase II subunit RPB1 is an enzyme that in humans is encoded by the POLR2A gene.-Interactions:POLR2A has been shown to interact with Transcription elongation regulator 1, CREB-binding protein, BRCA1, GTF2H4, TATA-binding protein, PCAF, GTF2F1, SUPT5H, Transcription Factor II...
, MED21
MED21
Mediator of RNA polymerase II transcription subunit 21 is an enzyme that in humans is encoded by the MED21 gene.-Interactions:MED21 has been shown to interact with Cyclin-dependent kinase 8, BRCA1, GTF2H4, MED6, POLR2A and GTF2F1.-Further reading:...
, SMARCB1
SMARCB1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 is a protein that in humans is encoded by the SMARCB1 gene.-Interactions:...
, MED12
MED12
Mediator of RNA polymerase II transcription, subunit 12 homolog , also known as MED12, is a human gene found on the X chromosome...
and CRSP3
CRSP3
Mediator of RNA polymerase II transcription subunit 23 is an enzyme that in humans is encoded by the MED23 gene.-Interactions:CRSP3 has been shown to interact with Estrogen receptor alpha, CEBPB and Cyclin-dependent kinase 8.-Further reading:...
.