CREB binding protein
Encyclopedia
CREB-binding protein, also known as CREBBP or CBP, is a protein
that in humans is encoded by the CREBBP gene
.
The CREB protein carries out its function by activating transcription, where interaction with transcription factors is managed by one or more of p300 domains: the nuclear receptor
interaction domain (RID), the CREB
and MYB
interaction domain (KIX), the cysteine
/histidine
regions (TAZ1/CH1 and TAZ2/CH3) and the interferon
response binding domain (IBiD). The CREB protein domains, KIX, TAZ1 and TAZ2, each bind tightly to a sequence spanning both transactivation domains 9aaTADs of transcription factor p53.
of many different transcription factor
s. First isolated as a nuclear protein that binds to cAMP-response element-binding protein (CREB
), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase
activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high-sequence similarity with protein EP300
in its bromodomain
, cysteine-histidine-rich regions, and histone acetyltransferase domain. Recent results suggest that novel CBP-mediated post-translational N-glycosylation activity alters the conformation of CBP-interacting proteins, leading to regulation of gene expression, cell growth and differentiation,
(RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia
.
with:
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the CREBBP gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
The CREB protein carries out its function by activating transcription, where interaction with transcription factors is managed by one or more of p300 domains: the nuclear receptor
Nuclear receptor
In the field of molecular biology, nuclear receptors are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules...
interaction domain (RID), the CREB
CREB
CREB is a cellular transcription factor. It binds to certain DNA sequences called cAMP response elements , thereby increasing or decreasing the transcription of the downstream genes....
and MYB
MYB
Myb proto-oncogene protein also known as transcriptional activator Myb is a protein that in humans is encoded by the MYB gene.- Function :...
interaction domain (KIX), the cysteine
Cysteine
Cysteine is an α-amino acid with the chemical formula HO2CCHCH2SH. It is a non-essential amino acid, which means that it is biosynthesized in humans. Its codons are UGU and UGC. The side chain on cysteine is thiol, which is polar and thus cysteine is usually classified as a hydrophilic amino acid...
/histidine
Histidine
Histidine Histidine, an essential amino acid, has a positively charged imidazole functional group. It is one of the 22 proteinogenic amino acids. Its codons are CAU and CAC. Histidine was first isolated by German physician Albrecht Kossel in 1896. Histidine is an essential amino acid in humans...
regions (TAZ1/CH1 and TAZ2/CH3) and the interferon
Interferon
Interferons are proteins made and released by host cells in response to the presence of pathogens—such as viruses, bacteria, or parasites—or tumor cells. They allow communication between cells to trigger the protective defenses of the immune system that eradicate pathogens or tumors.IFNs belong to...
response binding domain (IBiD). The CREB protein domains, KIX, TAZ1 and TAZ2, each bind tightly to a sequence spanning both transactivation domains 9aaTADs of transcription factor p53.
Function
This gene is ubiquitously expressed and is involved in the transcriptional coactivationCoactivation
Coactivation may mean:* Coactivation , a process by which RNA transcription is increased* Coactivation , a process in which a muscle is activated in tandem with another muscle...
of many different transcription factor
Transcription factor
In molecular biology and genetics, a transcription factor is a protein that binds to specific DNA sequences, thereby controlling the flow of genetic information from DNA to mRNA...
s. First isolated as a nuclear protein that binds to cAMP-response element-binding protein (CREB
CREB
CREB is a cellular transcription factor. It binds to certain DNA sequences called cAMP response elements , thereby increasing or decreasing the transcription of the downstream genes....
), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase
Histone acetyltransferase
Histone acetyltransferases are enzymes that acetylate conserved lysine amino acids on histone proteins by transferring an acetyl group from acetyl CoA to form ε-N-acetyl lysine....
activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high-sequence similarity with protein EP300
EP300
E1A binding protein p300 also known as EP300 or p300 is a protein that, in humans, is encoded by the EP300 gene. This protein regulates the activity of many genes in tissues throughout the body...
in its bromodomain
Bromodomain
A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. The domain itself adopts an all-α protein fold, a bundle of four alpha...
, cysteine-histidine-rich regions, and histone acetyltransferase domain. Recent results suggest that novel CBP-mediated post-translational N-glycosylation activity alters the conformation of CBP-interacting proteins, leading to regulation of gene expression, cell growth and differentiation,
Clinical significance
Mutations in this gene cause Rubinstein-Taybi syndromeRubinstein-Taybi syndrome
Rubinstein-Taybi Syndrome , also known as broad thumb-hallux syndrome or Rubinstein syndrome, is a condition characterized by short stature, moderate to severe learning difficulties, distinctive facial features, and broad thumbs and first toes. Other features of the disorder vary among affected...
(RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia
Acute myeloid leukemia
Acute myeloid leukemia , also known as acute myelogenous leukemia, is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells. AML is the most common acute...
.
Interactions
CREB-binding protein has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with:
- Activating transcription factor 2Activating transcription factor 2Activating transcription factor 2, also known as ATF2, is a protein that, in humans, is encoded by the ATF2 gene.-Function:This gene encodes a transcription factor that is a member of the leucine zipper family of DNA-binding proteins. This protein binds to the cAMP-responsive element , an octameric...
- Androgen receptorAndrogen receptorThe androgen receptor , also known as NR3C4 , is a type of nuclear receptor that is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone in the cytoplasm and then translocating into the nucleus...
- Autoimmune regulatorAutoimmune regulatorThe autoimmune regulator is a protein that in humans is encoded by the AIRE gene. AIRE is a transcription factor expressed in the medulla of the thymus and controls the mechanism that prevents the immune system from attacking the body itself....
- BRCA1BRCA1BRCA1 is a human caretaker gene that produces a protein called breast cancer type 1 susceptibility protein, responsible for repairing DNA. The first evidence for the existence of the gene was provided by the King laboratory at UC Berkeley in 1990...
- BRCA2BRCA2BRCA2 is a protein that in humans is encoded by the BRCA2 gene.BRCA2 orthologs have been identified in most mammals for which complete genome data are available....
- C-junC-junc-Jun is the name of a gene and protein that, in combination with c-Fos, forms the AP-1 early response transcription factor. It was first identified as the Fos-binding protein p39 and only later rediscovered as the product of the c-jun gene. It is activated through double phosphorylation by the...
- C-src tyrosine kinaseC-src tyrosine kinaseC-src tyrosine kinase, also known as CSK, is a human protein and gene. It includes an SH2 domain, an SH3 domain, and a tyrosine kinase domain. This protein specifically phosphorylates Tyr-504 residue on human leukocyte-specific protein tyrosine kinase, which acts as a negative regulatory site...
- Casein kinase 2, alpha 1
- Ccaat-enhancer-binding proteinsCcaat-enhancer-binding proteinsCCAAT-enhancer-binding proteins are a family of transcription factors, composed of six members called C/EBP α to C/EBP ζ. They promote the expression of certain genes through interaction with their promoter. Once bound to DNA, C/EBPs can recruit so-called coactivators CCAAT-enhancer-binding...
- CDX2CDX2Homeobox protein CDX-2 is a protein that in humans is encoded by the CDX2 gene. The protein encoded by this gene is a homeobox transcription factor.-Function:...
- CREB1CREB1CAMP responsive element binding protein 1, also known as CREB-1, is a protein that in humans is encoded by the CREB1 gene. This protein binds the cAMP response element, a DNA nucleotide sequence present in many viral and cellular promoters...
- CSNK2A2CSNK2A2Casein kinase II subunit alpha is an enzyme that in humans is encoded by the CSNK2A2 gene.-Interactions:CSNK2A2 has been shown to interact with CSNK2B, FGF1, PTEN, RELA, ATF1, Nucleolin, CREB binding protein, Activating transcription factor 2, PIN1, C-jun and C-Fos.-Further reading:...
- CUTL1CUTL1Cux1 is a homeodomain protein that in humans is encoded by the CUX1 gene.-Interactions:Cux1 has been shown to interact with CREB binding protein, SATB1 and Retinoblastoma protein....
- Cyclin-dependent kinase 8Cyclin-dependent kinase 8Cell division protein kinase 8 is an enzyme that in humans is encoded by the CDK8 gene.-Interactions:Cyclin-dependent kinase 8 has been shown to interact with MED16, MED26, MED17, MED14, CREB binding protein, MED1, MED6, MED24, CCNC, POLR2A, MED21, SMARCB1, MED12 and CRSP3....
- EBF1EBF1Transcription factor COE1 is a protein that in humans is encoded by the EBF1 gene.-Interactions:EBF1 has been shown to interact with ZNF423 and CREB binding protein.-External links:...
- Estrogen receptor alphaEstrogen receptor alphaEstrogen receptor alpha , also known as NR3A1 , is a nuclear receptor that is activated by the sex hormone estrogen...
- EVI1EVI1MDS1 and EVI1 complex locus protein EVI1 also known as ecotropic virus integration site 1 protein homolog or positive regulatory domain zinc finger protein 3 is a protein that in humans is encoded by the MECOM gene. EVI1 was first identified as a common retroviral integration site in AKXD murine...
- FOXO1FOXO1Forkhead box protein O1 also known as forkhead in rhabdomyosarcoma is a protein that in humans is encoded by the FOXO1 gene.- Function :...
- GLI3Gli3Zinc finger protein GLI3 is a protein that in humans is encoded by the GLI3 gene.This gene encodes a protein that belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog signaling...
- Glucocorticoid receptorGlucocorticoid receptorThe glucocorticoid receptor also known as NR3C1 is the receptor to which cortisol and other glucocorticoids bind....
- Hepatocyte nuclear factor 4 alphaHepatocyte nuclear factor 4 alphaHepatocyte nuclear factor 4 alpha also known as NR2A1 is a nuclear receptor that in humans is encoded by the HNF4A gene.- Function :...
- HIF1AHIF1AHypoxia-inducible factor 1, alpha subunit , also known as HIF1A, is a protein that in humans is encoded by the HIF1A gene...
- HIPK2HIPK2Homeodomain-interacting protein kinase 2 is an enzyme that in humans is encoded by the HIPK2 gene.-Interactions:HIPK2 has been shown to interact with SKI protein, Death associated protein 6, P53, CREB binding protein, Mothers against decapentaplegic homolog 1, TP53INP1 and RANBP9.-Further reading:...
- HNF1AHNF1AHNF1 homeobox A , also known as HNF1A, is a human gene.The protein encoded by this gene is a transcription factor that is highly expressed in the liver and is involved in the regulation of the expression of several liver-specific genes.-Interactions:HNF1A has been shown to interact with PCAF, Src,...
- HOXB7HOXB7Homeobox protein Hox-B7 is a protein that in humans is encoded by the HOXB7 gene.-Interactions:HOXB7 has been shown to interact with PBX1 and CREB-binding protein.-Further reading:...
- ING1ING1Inhibitor of growth protein 1 is a protein that in humans is encoded by the ING1 gene.-Location on Chromosome 13:ING1 is located near the following genes on Chromosome 13*CARKD Carbohydrate Kinase Domain-Containing Protein...
- KHDRBS1KHDRBS1KH domain-containing, RNA-binding, signal transduction-associated protein 1 is a protein that in humans is encoded by the KHDRBS1 gene.-Further reading:...
- KLF13KLF13Kruppel-like factor 13, also known as KLF13, is a protein that in humans is encoded by the KLF13 gene.- Function :KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2...
- KLF4KLF4Krueppel-like factor 4 is a protein that in humans is encoded by the KLF4 gene.. In embryonic stem cells , KLF4 has been demonstrated to be a good indicator of stem-like capacity. It is suggested that the same is true in mesenchymal stem cells ....
- Ku70
- MAFMAF (gene)Transcription factor Maf also known as proto-oncogene c-Maf or V-maf musculoaponeurotic fibrosarcoma oncogene homolog is a transcription factor that in humans is encoded by the MAF gene.-Types:...
- MLLMLL (gene)Histone-lysine N-methyltransferase HRX is an enzyme that in humans is encoded by the MLL gene.MLL is a histone methyltransferase deemed a positive global regulator of gene transcription...
- Mothers against decapentaplegic homolog 1Mothers against decapentaplegic homolog 1Mothers against decapentaplegic homolog 1 also known as SMAD family member 1 or SMAD1 is a protein that in humans is encoded by the SMAD1 gene.-Nomenclature:...
- MSX1MSX1Msh homeobox 1, also known as MSX1, is a protein that in humans is encoded by the MSX1 gene. MSX1 transcripts are not only found in thyrotrope-derived TSH cells, but also in the TtT97 thyrotropic tumor, which is a well differentiated hyperplastic tissue that produces both TSHß- and a-subunits and...
- MYBMYBMyb proto-oncogene protein also known as transcriptional activator Myb is a protein that in humans is encoded by the MYB gene.- Function :...
- MYBL2MYBL2Myb-related protein B is a protein that in humans is encoded by the MYBL2 gene.-Interactions:MYBL2 has been shown to interact with Retinoblastoma-like protein 1, Cyclin A1, EP300, CREB-binding protein, CDK9, Cyclin-dependent kinase inhibitor 1C and PARP1.-Further reading:...
- MyoDMyoDMyoD is a protein with a key role in regulating muscle differentiation. MyoD belongs to a family of proteins known as myogenic regulatory factors . These bHLH transcription factors act sequentially in myogenic differentiation. MRF family members include MyoD, Myf5, myogenin, and MRF4 .MyoD is one...
- NCOA6NCOA6Nuclear receptor coactivator 6 is a protein that in humans is encoded by the NCOA6 gene.-Interactions:NCOA6 has been shown to interact with Ku70, RBBP5, E2F1, Retinoblastoma protein, CREB-binding protein, Activating transcription factor 2, HSF1, HBXIP, TGS1, TUBB, TUBA4A, Thyroid hormone receptor...
- NEUROG1NEUROG1Neurogenin-1 is a protein that in humans is encoded by the NEUROG1 gene.-Interactions:NEUROG1 has been shown to interact with CREB-binding protein and Mothers against decapentaplegic homolog 1.-Further reading:...
- NFATC4NFATC4Nuclear factor of activated T-cells, cytoplasmic 4 is a protein that in humans is encoded by the NFATC4 gene.NFAT transcription factors are implicated in breast cancer, more specifically in the process of cell motility at the basis of metastasis formation...
- NFE2NFE2Transcription factor NF-E2 45 kDa subunit is a protein that in humans is encoded by the NFE2 gene.-Interactions:NFE2 has been shown to interact with CREB-binding protein.- External links :...
- NFE2L2NFE2L2Nuclear factor -like 2, also known as NFE2L2 or Nrf2, is a transcription factor that in humans is encoded by the NFE2L2 gene. NFE2L2 induces the expression of various genes including those that encode for several antioxidant enzymes, and it may play a physiological role in the regulation of...
- Nuclear receptor coactivator 1Nuclear receptor coactivator 1The nuclear receptor coactivator 1 is a transcriptional coregulatory protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity . NCOA1 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA1, in turn, acylates...
- Nuclear receptor coactivator 3Nuclear receptor coactivator 3The nuclear receptor coactivator 3 also known as NCOA3 is a protein that, in humans, is encoded by the NCOA3 gene. NCOA3 is also frequently called 'amplified in breast 1' , steroid receptor coactivator-3 , or thyroid hormone receptor activator molecule 1 .-Function:NCOA3 is a transcriptional...
- NUP98NUP98Nuclear pore complex protein Nup98-Nup96 is a protein that in humans is encoded by the NUP98 gene.-Interactions:NUP98 has been shown to interact with NUP88, KPNB1, RAE1, CREB-binding protein and TNPO2.-Further reading:...
- P53P53p53 , is a tumor suppressor protein that in humans is encoded by the TP53 gene. p53 is crucial in multicellular organisms, where it regulates the cell cycle and, thus, functions as a tumor suppressor that is involved in preventing cancer...
- PCAFPCAFP300/CBP-associated factor , also known as K acetyltransferase 2B , is a human gene and trancriptional coactivator associated with p53.-Structure:...
- POLR2APOLR2ADNA-directed RNA polymerase II subunit RPB1 is an enzyme that in humans is encoded by the POLR2A gene.-Interactions:POLR2A has been shown to interact with Transcription elongation regulator 1, CREB-binding protein, BRCA1, GTF2H4, TATA-binding protein, PCAF, GTF2F1, SUPT5H, Transcription Factor II...
- PPARGC1APPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha is a protein that in humans is encoded by the PPARGC1A gene....
- Promyelocytic leukemia proteinPromyelocytic leukemia proteinProbable transcription factor PML is a tumor suppressor protein that in humans is encoded by the PML gene.-Interactions:Promyelocytic leukemia protein has been shown to interact with Retinoic acid receptor alpha, HDAC1, Nerve Growth factor IB, SKI protein, Zinc finger and BTB domain-containing...
- PTMA
- RBBP4RBBP4Histone-binding protein RBBP4 is a protein that in humans is encoded by the RBBP4 gene.-Interactions:RBBP4 has been shown to interact with HDAC1, Histone deacetylase 2, SIN3A, Retinoblastoma protein, SAP30, CREB-binding protein, GATAD2B, BRCA1, MTA2 and HDAC3.-Further reading:...
- RELARELATranscription factor p65 is a protein that in humans is encoded by the RELA gene.-Interactions:RELA has been shown to interact with NFKBIB, ETHE1, NFKBIE, RFC1, TRIB3, CREB binding protein, Neutrophil cytosolic factor 1, Glucocorticoid receptor, MTPN, BRCA1, C-Fos, POU2F1, BTRC, TATA-binding...
- RPS6KA3RPS6KA3Ribosomal protein S6 kinase, 90kDa, polypeptide 3, also known as RPS6KA3, is an enzyme that in humans is encoded by the RPS6KA3 gene.- Function :This gene encodes a member of the RSK family of serine/threonine kinases...
- SERTAD1SERTAD1SERTA domain-containing protein 1 is a protein that in humans is encoded by the SERTAD1 gene.-Interactions:SERTAD1 has been shown to interact with P16, Cyclin-dependent kinase 4 and CREB-binding protein.-Further reading:...
- Serum response factorSerum response factorSerum response factor , also known as SRF, is a transcription factor.It is a member of the MADS box superfamily of transcription factors. This protein binds to the serum response element in the promoter region of target genes...
- SMARCB1SMARCB1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 is a protein that in humans is encoded by the SMARCB1 gene.-Interactions:...
- SMARCA4SMARCA4Transcription activator BRG1 also known as ATP-dependent helicase SMARCA4 is a protein that in humans is encoded by the SMARCA4 gene.- Function :...
- SREBF1SREBF1Sterol regulatory element-binding transcription factor 1 also known as sterol regulatory element-binding protein 1 is a protein that in humans is encoded by the SREBF1 gene....
- SREBF2SREBF2Sterol regulatory element-binding protein 2 also known as sterol regulatory element binding transcription factor 2 is a protein that in humans is encoded by the SREBF2 gene.- Function :...
- SS18L1SS18L1SS18-like protein 1 is a protein that in humans is encoded by the SS18L1 gene.-Interactions:SS18L1 has been shown to interact with CREB-binding protein.-Further reading:...
- STAT1STAT1STAT1 is a member of the Signal Transducers and Activators of Transcription family of transcription factors. STAT1 is involved in upregulating genes due to a signal by either type I, type II or type III interferons...
- STAT2STAT2Signal transducer and activator of transcription 2 is a protein that in humans is encoded by the STAT2 gene.-Interactions:STAT2 has been shown to interact with MED14, CREB-binding protein, SMARCA4, STAT1, IFNAR2, IFNAR1 and ISGF3G.-Further reading:...
- STAT6STAT6STAT6 is a human gene. The protein encoded by this gene is a member of the STAT family of transcription factors.In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell...
- TCF3TCF3Transcription factor 3 , also known as TCF3, is a protein that in humans is encoded by the TCF3 gene...
- TGS1TGS1Trimethylguanosine synthase is an enzyme that in humans is encoded by the TGS1 gene.-Interactions:TGS1 has been shown to interact with NCOA6, MED1, EP300, CREB-binding protein and EED.-Further reading:...
- Thymine-DNA glycosylaseThymine-DNA glycosylaseG/T mismatch-specific thymine DNA glycosylase is an enzyme that in humans is encoded by the TDG gene.-Interactions:Thymine-DNA glycosylase has been shown to interact with Estrogen receptor alpha, SUMO3, CREB-binding protein, Promyelocytic leukemia protein and Small ubiquitin-related modifier...
- Transcription Factor II BTranscription Factor II BTranscription factor II B is one of several general transcription factors that make up the RNA polymerase II preinitiation complex. It is encoded by the gene....
- TRERF1TRERF1Transcriptional-regulating factor 1 is a protein that in humans is encoded by the TRERF1 gene.-Interactions:TRERF1 has been shown to interact with Steroidogenic factor 1, EP300 and CREB-binding protein.-Further reading:...
- Zif268Zif268EGR-1 also known as Zif268 or NGFI-A is a protein that in humans is encoded by the EGR1 gene....
.