HNF1A
Encyclopedia
HNF1 homeobox A also known as HNF1A, is a human gene
.
The protein
encoded by this gene is a transcription factor
that is highly expressed in the liver and is involved in the regulation of the expression of several liver-specific genes.
with PCAF
, Src
, RAC3
, EP300
, CREB-binding protein and PCBD1
.
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
The protein
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
encoded by this gene is a transcription factor
Transcription factor
In molecular biology and genetics, a transcription factor is a protein that binds to specific DNA sequences, thereby controlling the flow of genetic information from DNA to mRNA...
that is highly expressed in the liver and is involved in the regulation of the expression of several liver-specific genes.
Interactions
HNF1A has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with PCAF
PCAF
P300/CBP-associated factor , also known as K acetyltransferase 2B , is a human gene and trancriptional coactivator associated with p53.-Structure:...
, Src
Src (gene)
Proto-oncogene tyrosine-protein kinase Src is an enzyme that in humans is encoded by the SRC gene.Src is a proto-oncogene encoding a tyrosine kinase originally discovered by J. Michael Bishop and Harold E. Varmus, for which they won the 1989 Nobel Prize in Physiology or Medicine. It belongs to a...
, RAC3
RAC3
Ras-related C3 botulinum toxin substrate 3 is a protein that in humans is encoded by the RAC3 gene.-Interactions:RAC3 has been shown to interact with CIB1 and HNF1A.-External links:* Info with links in the...
, EP300
EP300
E1A binding protein p300 also known as EP300 or p300 is a protein that, in humans, is encoded by the EP300 gene. This protein regulates the activity of many genes in tissues throughout the body...
, CREB-binding protein and PCBD1
PCBD1
Pterin-4-alpha-carbinolamine dehydratase is an enzyme that in humans is encoded by the PCBD1 gene.-Interactions:PCBD1 has been shown to interact with DYRK1B and HNF1A.-Further reading:...
.