SREBF2
Encyclopedia
Sterol regulatory element-binding protein 2 (SREBP-2) also known as sterol regulatory element binding transcription factor 2 (SREBF2) is a protein
that in humans is encoded by the SREBF2 gene
.
that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic-helix-loop-helix leucine zipper (bHLH-Zip
) domain.
with INSIG1
and CREB-binding protein.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the SREBF2 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Function
This gene encodes a ubiquitously expressed transcription factorTranscription factor
In molecular biology and genetics, a transcription factor is a protein that binds to specific DNA sequences, thereby controlling the flow of genetic information from DNA to mRNA...
that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic-helix-loop-helix leucine zipper (bHLH-Zip
Basic helix-loop-helix leucine zipper transcription factors
Basic helix-loop-helix leucine zipper transcription factors are, as their name indicates, transcription factors containing both Basic helix-loop-helix and leucine zipper motifs.An example is Microphthalmia-associated transcription factor....
) domain.
Interactions
SREBF2 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with INSIG1
INSIG1
Insulin induced gene 1, also known as INSIG1, is a protein which in humans is encoded by the INSIG1 gene.- Function :Oxysterols regulate cholesterol homeostasis through liver X receptor and sterol regulatory element-binding protein mediated signaling pathway. This gene is an insulin-induced gene...
and CREB-binding protein.