The nuclear receptor coactivator 1 is a transcriptional coregulatory protein that contains several nuclear receptor

Nuclear receptor

In the field of molecular biology, nuclear receptors are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules...

 interacting domains and an intrinsic histone acetyltransferase

Histone acetyltransferase

Histone acetyltransferases are enzymes that acetylate conserved lysine amino acids on histone proteins by transferring an acetyl group from acetyl CoA to form ε-N-acetyl lysine....

 activity . NCOA1 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA1, in turn, acylates histones, which makes downsteam DNA more accessible to transcription. Hence, NCOA1 assists nuclear receptors in the upregulation of DNA expression.

NCOA1 is also frequently called steroid receptor coactivator-1 (SRC-1).

Interactions

Nuclear receptor coactivator 1 has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with Thyroid hormone receptor beta

Thyroid hormone receptor beta

Thyroid hormone receptor beta also known as nuclear receptor subfamily 1, group A, member 2 , is a nuclear receptor protein that in humans is encoded by the THRB gene.- Function :...

, CIITA

CIITA

CIITA is a human gene which encodes a protein called the class II, major histocompatibility complex, transactivator. Mutations in this gene are responsible for the bare lymphocyte syndrome in which the immune system is severely compromised and cannot effectively fight infection...

, DDX17

DDX17

Probable ATP-dependent RNA helicase DDX17 is an enzyme that in humans is encoded by the DDX17 gene.-Interactions:DDX17 has been shown to interact with HDAC1, Nuclear receptor coactivator 1, Nuclear receptor coactivator 3, Estrogen receptor alpha, Nuclear receptor coactivator 2, SRA1,, DDX5 and...

, SNW1

SNW1

SNW domain-containing protein 1 is a protein that in humans is encoded by the SNW1 gene.-Interactions:SNW1 has been shown to interact with Histone deacetylase 2, SKI protein, Retinoblastoma protein, PABPN1, CIR, RBPJ, Nuclear receptor coactivator 1, Nuclear receptor co-repressor 2, Calcitriol...

, Androgen receptor

Androgen receptor

The androgen receptor , also known as NR3C4 , is a type of nuclear receptor that is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone in the cytoplasm and then translocating into the nucleus...

, STAT3

STAT3

Signal transducer and activator of transcription 3 also known as STAT3 is a transcription factor which in humans is encoded by the STAT3 gene.- Function :The protein encoded by this gene is a member of the STAT protein family...

, CREB-binding protein, Glucocorticoid receptor

Glucocorticoid receptor

The glucocorticoid receptor also known as NR3C1 is the receptor to which cortisol and other glucocorticoids bind....

, Peroxisome proliferator-activated receptor alpha

Peroxisome proliferator-activated receptor alpha

Peroxisome proliferator-activated receptor alpha , also known as NR1C1 , is a nuclear receptor protein that in humans is encoded by the PPARA gene.- Function :...

, TRIP4

TRIP4

Activating signal cointegrator 1 is a protein that in humans is encoded by the TRIP4 gene.-Interactions:TRIP4 has been shown to interact with Nuclear receptor coactivator 1.-Further reading:...

, C-Fos

C-Fos

In the field of molecular biology and Genetics, c-Fos is a protein encoded by the FOS gene.-Structure and function:c-Fos is a cellular proto-oncogene belonging to the immediate early gene family of transcription factors. c-Fos has a leucine-zipper DNA binding domain, and a transactivation domain at...

, STAT6

STAT6

STAT6 is a human gene. The protein encoded by this gene is a member of the STAT family of transcription factors.In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell...

, PCAF

PCAF

P300/CBP-associated factor , also known as K acetyltransferase 2B , is a human gene and trancriptional coactivator associated with p53.-Structure:...

, PPARGC1A

PPARGC1A

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha is a protein that in humans is encoded by the PPARGC1A gene....

, NFKB1

NFKB1

Nuclear factor NF-kappa-B p105 subunit is a protein that in humans is encoded by the NFKB1 gene.This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and...

, Cyclin D1

Cyclin D1

G1/S-specific cyclin-D1 is a protein that in humans is encoded by the CCND1 gene.Immunohistochemical staining of cyclin D1 antibodies is used to diagnose mantle cell lymphoma.-Interactions:...

, Estrogen receptor alpha

Estrogen receptor alpha

Estrogen receptor alpha , also known as NR3A1 , is a nuclear receptor that is activated by the sex hormone estrogen...

, DDX5

DDX5

Probable ATP-dependent RNA helicase DDX5 also known as DEAD box protein 5 or RNA helicase p68 is an enzyme that in humans is encoded by the DDX5 gene.- Function :...

 and C-jun

C-jun

c-Jun is the name of a gene and protein that, in combination with c-Fos, forms the AP-1 early response transcription factor. It was first identified as the Fos-binding protein p39 and only later rediscovered as the product of the c-jun gene. It is activated through double phosphorylation by the...

.

Further reading