DNA polymerase eta
Encyclopedia
DNA polymerase eta is a eukaryotic DNA polymerase
involved in the DNA repair by translesion synthesis. The gene encoding DNA polymerase eta is POLH
, also known as XPV, because loss of this gene results in the disease Xeroderma Pigmentosum Variant. Polymerase eta is particularly important for allowing accurate translesion synthesis of DNA damage resulting from ultraviolet radiation or UV.
DNA polymerase
A DNA polymerase is an enzyme that helps catalyze in the polymerization of deoxyribonucleotides into a DNA strand. DNA polymerases are best known for their feedback role in DNA replication, in which the polymerase "reads" an intact DNA strand as a template and uses it to synthesize the new strand....
involved in the DNA repair by translesion synthesis. The gene encoding DNA polymerase eta is POLH
POLH
Polymerase , eta, also known as POLH, is a protein which in humans is encoded by the POLH gene.-Function:This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases...
, also known as XPV, because loss of this gene results in the disease Xeroderma Pigmentosum Variant. Polymerase eta is particularly important for allowing accurate translesion synthesis of DNA damage resulting from ultraviolet radiation or UV.