David Jaffray
Encyclopedia
David A. Jaffray PhD is a Canadian
medical physicist and Senior Scientist
in the Division of Biophysics
and Bioimaging at the Ontario Cancer Institute
. He is also a professor and Vice Chair in the University of Toronto
's Department of Radiation Oncology. He is the inventor, together with John Wong, of on-line volumetric kv-imaging guidance
system for radiation therapy
.
Jaffray's work focuses on the development of novel imaging systems and concepts to improve the precision of therapy by generating images at the time of therapy for the purpose of guiding the treatment delivery. Recent developments have included the construction of megavoltag] and kilovoltage imaging systems based upon high-performance charged coupled device cameras, prototyping, and evaluation of amorphous-silicon based large-area detectors for megavoltage work.
In addition, a kilovoltage cone-beam
computed tomography
(CT) system has been developed. These systems have been integrated with the megavoltage treatment devices to improve the precision with which the therapy could be executed without the interference of mechanical immobilization systems. The cone-beam CT approach has also been extended to a mobile C-arm for intra-operative imaging and therapy guidance.
A direct by-product of these investigations is the development of clinical processes that can use the images generated by these systems in a sensible and robust fashion. The development of such image-guidance processes is an active area of ongoing research in the program. This area has been broadened through the use of cinematographic magnetic resonance imaging (MR) sequences that permit the spatial instabilities that are inherent in the human body to be assessed. These assessments describe a lower limit on the precision with which non-invasive therapy can be applied and they must be considered in the development of robust treatment regimens.
He was named as one of "Canada's Top 40 Under 40" in 2003 by Caldwell Partners.
Canada
Canada is a North American country consisting of ten provinces and three territories. Located in the northern part of the continent, it extends from the Atlantic Ocean in the east to the Pacific Ocean in the west, and northward into the Arctic Ocean...
medical physicist and Senior Scientist
Scientist
A scientist in a broad sense is one engaging in a systematic activity to acquire knowledge. In a more restricted sense, a scientist is an individual who uses the scientific method. The person may be an expert in one or more areas of science. This article focuses on the more restricted use of the word...
in the Division of Biophysics
Biophysics
Biophysics is an interdisciplinary science that uses the methods of physical science to study biological systems. Studies included under the branches of biophysics span all levels of biological organization, from the molecular scale to whole organisms and ecosystems...
and Bioimaging at the Ontario Cancer Institute
Ontario Cancer Institute
The Ontario Cancer Institute is the research division of Princess Margaret Hospital, part of the University Health Network of the University of Toronto Faculty of Medicine. As Canada's first dedicated cancer hospital, it opened officially and began to receive patients in 1958, although its...
. He is also a professor and Vice Chair in the University of Toronto
University of Toronto
The University of Toronto is a public research university in Toronto, Ontario, Canada, situated on the grounds that surround Queen's Park. It was founded by royal charter in 1827 as King's College, the first institution of higher learning in Upper Canada...
's Department of Radiation Oncology. He is the inventor, together with John Wong, of on-line volumetric kv-imaging guidance
Image-guided radiation therapy
Highly trained oncologists called radiation oncologists use image guided radiation therapy, or IGRT, to help better deliver radiation therapy to cancerous tumors. This is very useful since tumors can move between treatments due to differences in organ filling or movements while breathing...
system for radiation therapy
Radiation therapy
Radiation therapy , radiation oncology, or radiotherapy , sometimes abbreviated to XRT or DXT, is the medical use of ionizing radiation, generally as part of cancer treatment to control malignant cells.Radiation therapy is commonly applied to the cancerous tumor because of its ability to control...
.
Jaffray's work focuses on the development of novel imaging systems and concepts to improve the precision of therapy by generating images at the time of therapy for the purpose of guiding the treatment delivery. Recent developments have included the construction of megavoltag] and kilovoltage imaging systems based upon high-performance charged coupled device cameras, prototyping, and evaluation of amorphous-silicon based large-area detectors for megavoltage work.
In addition, a kilovoltage cone-beam
Cone beam reconstruction
For microtomography, X-ray scanners typically use two methods for scanning:*Fan beam reconstruction* Cone beam reconstruction.Cone beam reconstruction uses a 2-dimensional approach for obtaining projection data. Instead of utilizing a single row of detectors, as fan beam methods do, a cone beam...
computed tomography
Computed tomography
X-ray computed tomography or Computer tomography , is a medical imaging method employing tomography created by computer processing...
(CT) system has been developed. These systems have been integrated with the megavoltage treatment devices to improve the precision with which the therapy could be executed without the interference of mechanical immobilization systems. The cone-beam CT approach has also been extended to a mobile C-arm for intra-operative imaging and therapy guidance.
A direct by-product of these investigations is the development of clinical processes that can use the images generated by these systems in a sensible and robust fashion. The development of such image-guidance processes is an active area of ongoing research in the program. This area has been broadened through the use of cinematographic magnetic resonance imaging (MR) sequences that permit the spatial instabilities that are inherent in the human body to be assessed. These assessments describe a lower limit on the precision with which non-invasive therapy can be applied and they must be considered in the development of robust treatment regimens.
He was named as one of "Canada's Top 40 Under 40" in 2003 by Caldwell Partners.