Diacylglycerol cholinephosphotransferase
Encyclopedia
In enzymology, a diacylglycerol cholinephosphotransferase is an enzyme
that catalyzes
the chemical reaction
Thus, the two substrates
of this enzyme are CDP-choline and 1,2-diacylglycerol, whereas its two products
are CMP
and phosphatidylcholine
.
This enzyme belongs to the family of transferase
s, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is CDP choline:1,2-diacylglycerol cholinephosphotransferase. Other names in common use include phosphorylcholine-glyceride transferase, alkylacylglycerol cholinephosphotransferase, 1-alkyl-2-acetylglycerol cholinephosphotransferase, cholinephosphotransferase, CPT, alkylacylglycerol choline phosphotransferase, diacylglycerol choline phosphotransferase, 1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase, CDP-choline diglyceride phosphotransferase, cytidine diphosphocholine glyceride transferase, cytidine diphosphorylcholine diglyceride transferase, phosphocholine diacylglyceroltransferase, sn-1,2-diacylglycerol cholinephosphotransferase, and 1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase. This enzyme participates in 3 metabolic pathways
: aminophosphonate metabolism, glycerophospholipid metabolism, and ether lipid metabolism.
Enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
that catalyzes
Catalysis
Catalysis is the change in rate of a chemical reaction due to the participation of a substance called a catalyst. Unlike other reagents that participate in the chemical reaction, a catalyst is not consumed by the reaction itself. A catalyst may participate in multiple chemical transformations....
the chemical reaction
Chemical reaction
A chemical reaction is a process that leads to the transformation of one set of chemical substances to another. Chemical reactions can be either spontaneous, requiring no input of energy, or non-spontaneous, typically following the input of some type of energy, such as heat, light or electricity...
- CDP-choline + 1,2-diacylglycerol CMP + a phosphatidylcholine
Thus, the two substrates
Substrate (biochemistry)
In biochemistry, a substrate is a molecule upon which an enzyme acts. Enzymes catalyze chemical reactions involving the substrate. In the case of a single substrate, the substrate binds with the enzyme active site, and an enzyme-substrate complex is formed. The substrate is transformed into one or...
of this enzyme are CDP-choline and 1,2-diacylglycerol, whereas its two products
Product (chemistry)
Product are formed during chemical reactions as reagents are consumed. Products have lower energy than the reagents and are produced during the reaction according to the second law of thermodynamics. The released energy comes from changes in chemical bonds between atoms in reagent molecules and...
are CMP
Cytidine monophosphate
Cytidine monophosphate, also known as 5'-cytidylic acid or simply cytidylate, and abbreviated CMP, is a nucleotide that is used as a monomer in RNA. It is an ester of phosphoric acid with the nucleoside cytidine...
and phosphatidylcholine
Phosphatidylcholine
Phosphatidylcholines are a class of phospholipids that incorporate choline as a headgroup.They are a major component of biological membranes and can be easily obtained from a variety of readily available sources such as egg yolk or soy beans from which they are mechanically extracted or chemically...
.
This enzyme belongs to the family of transferase
Transferase
In biochemistry, a transferase is an enzyme that catalyzes the transfer of a functional group from one molecule to another . For example, an enzyme that catalyzed this reaction would be a transferase:In this example, A would be the donor, and B would be the acceptor...
s, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is CDP choline:1,2-diacylglycerol cholinephosphotransferase. Other names in common use include phosphorylcholine-glyceride transferase, alkylacylglycerol cholinephosphotransferase, 1-alkyl-2-acetylglycerol cholinephosphotransferase, cholinephosphotransferase, CPT, alkylacylglycerol choline phosphotransferase, diacylglycerol choline phosphotransferase, 1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase, CDP-choline diglyceride phosphotransferase, cytidine diphosphocholine glyceride transferase, cytidine diphosphorylcholine diglyceride transferase, phosphocholine diacylglyceroltransferase, sn-1,2-diacylglycerol cholinephosphotransferase, and 1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase. This enzyme participates in 3 metabolic pathways
Metabolism
Metabolism is the set of chemical reactions that happen in the cells of living organisms to sustain life. These processes allow organisms to grow and reproduce, maintain their structures, and respond to their environments. Metabolism is usually divided into two categories...
: aminophosphonate metabolism, glycerophospholipid metabolism, and ether lipid metabolism.