Equilibrative nucleoside transporter
Encyclopedia
The equilibrative nucleoside transporter (ENT) family, also known as SLC29, is a group of plasmalemmal transport proteins which transport nucleoside
substrates
like adenosine into cell
s. There are four known ENTs, designated ENT1, ENT2, ENT3, and ENT4. ENTs are blocked
by adenosine reuptake inhibitor
s like dipyridamole
and dilazep
, drugs used clinically for their vasodilatory
properties.
Nucleoside
Nucleosides are glycosylamines consisting of a nucleobase bound to a ribose or deoxyribose sugar via a beta-glycosidic linkage...
substrates
Substrate (biochemistry)
In biochemistry, a substrate is a molecule upon which an enzyme acts. Enzymes catalyze chemical reactions involving the substrate. In the case of a single substrate, the substrate binds with the enzyme active site, and an enzyme-substrate complex is formed. The substrate is transformed into one or...
like adenosine into cell
Cell (biology)
The cell is the basic structural and functional unit of all known living organisms. It is the smallest unit of life that is classified as a living thing, and is often called the building block of life. The Alberts text discusses how the "cellular building blocks" move to shape developing embryos....
s. There are four known ENTs, designated ENT1, ENT2, ENT3, and ENT4. ENTs are blocked
Reuptake inhibitor
A reuptake inhibitor , also known as a transporter blocker, is a drug that inhibits the plasmalemmal transporter-mediated reuptake of a neurotransmitter from the synapse into the pre-synaptic neuron, leading to an increase in the extracellular concentrations of the neurotransmitter and therefore an...
by adenosine reuptake inhibitor
Adenosine reuptake inhibitor
An adenosine reuptake inhibitor is a type of drug which acts as a reuptake inhibitor for the purine nucleoside and neurotransmitter adenosine by blocking the action of one or more of the equilibrative nucleoside transporters . This in turn leads to increased extracellular concentrations of...
s like dipyridamole
Dipyridamole
Dipyridamole is a drug that inhibits thrombus formation when given chronically and causes vasodilation when given at high doses over a short time.-Mechanism and effects:...
and dilazep
Dilazep
Dilazep is a vasodilator that acts as an adenosine reuptake inhibitor....
, drugs used clinically for their vasodilatory
Vasodilation
Vasodilation refers to the widening of blood vessels resulting from relaxation of smooth muscle cells within the vessel walls, particularly in the large arteries, smaller arterioles and large veins. The process is essentially the opposite of vasoconstriction, or the narrowing of blood vessels. When...
properties.