FLT4
Encyclopedia
Fms-related tyrosine kinase 4, also known as FLT4, is a protein
which in humans is encoded by the FLT4 gene
.
This gene encodes a tyrosine kinase
receptor for vascular endothelial growth factor
s C
and D. The protein is thought to be involved in lymphangiogenesis
and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema
type IA.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
which in humans is encoded by the FLT4 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
This gene encodes a tyrosine kinase
Tyrosine kinase
A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a protein in a cell. It functions as an "on" or "off" switch in many cellular functions....
receptor for vascular endothelial growth factor
Vascular endothelial growth factor
Vascular endothelial growth factor is a signal protein produced by cells that stimulates vasculogenesis and angiogenesis. It is part of the system that restores the oxygen supply to tissues when blood circulation is inadequate....
s C
Vascular endothelial growth factor C
Vascular endothelial growth factor C is a VEGF. The human gene encoding it is VEGFC.-Pathological VEGF-C Expression:Lymphedema is caused by an imbalance between lymphatic vessel formation and absorption...
and D. The protein is thought to be involved in lymphangiogenesis
Lymphangiogenesis
Lymphangiogenesis is the formation of lymphatic vessels from pre-existing lymphatic vessels, in a method believed to be similar to blood vessel development or angiogenesis....
and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema
Lymphedema
Lymphedema , also known as lymphatic obstruction, is a condition of localized fluid retention and tissue swelling caused by a compromised lymphatic system....
type IA.