Fibrin degradation product
Encyclopedia
Fibrin degradation product (FDPs), also known as fibrin split products, are components of the blood produced by clot degeneration.
These are produced by the action of plasmin
on deposited fibrin. The most notable subtype of fibrin degradation products is D-dimer
.
The levels of these FDPs rises after any thrombotic event.
It can be used to test for disseminated intravascular coagulation
.
These are produced by the action of plasmin
Plasmin
Plasmin is an important enzyme present in blood that degrades many blood plasma proteins, most notably, fibrin clots. The degradation of fibrin is termed fibrinolysis. In humans, the plasmin protein is encoded by the PLG gene.- Function :...
on deposited fibrin. The most notable subtype of fibrin degradation products is D-dimer
D-dimer
D-dimer is a fibrin degradation product , a small protein fragment present in the blood after a blood clot is degraded by fibrinolysis. It is so named because it contains two crosslinked D fragments of the fibrinogen protein....
.
The levels of these FDPs rises after any thrombotic event.
It can be used to test for disseminated intravascular coagulation
Disseminated intravascular coagulation
Disseminated intravascular coagulation , also known as disseminated intravascular coagulopathy or consumptive coagulopathy, is a pathological activation of coagulation mechanisms that happens in response to a variety of diseases. DIC leads to the formation of small blood clots inside the blood...
.