Florfenicol
Encyclopedia
Florfenicol is a fluorinated synthetic analog of thiamphenicol
.
In the United States, florfenicol is currently indicated for the treatment of bovine respiratory disease (BRD) associated with Mannheimia (Pasteurella) haemolytica, Pasteurella multocida
, and Haemophilus somnus, for treatment of bovine interdigital phlegmon
(foot rot, acute interdigital necrobacillosis, infectious pododermatitis) associated with Fusobacterium necrophorum
and Bacteroides melaninogenicus
.
The use of florfenicol in horses, and likely in other equids, typically causes diarrhea. This has been anecdotally reported to progress to lethal cases of acute colitis. Therefore, use of this antimicrobial in the equine patient should be limited to cases in which other, safer, options are not available.
Thiamphenicol
Thiamphenicol is an antibiotic. It is the methyl-sulfonyl analogue of chloramphenicol and has a similar spectrum of activity, but is 2.5 to 5 times as potent. Like chloramphenicol, it is insoluble in water, but highly soluble in lipids...
.
In the United States, florfenicol is currently indicated for the treatment of bovine respiratory disease (BRD) associated with Mannheimia (Pasteurella) haemolytica, Pasteurella multocida
Pasteurella multocida
Pasteurella multocida is a Gram-negative, non-motile coccobacillus that is penicillin-sensitive and belongs to the Pasteurellaceae family . It can cause avian cholera in birds and a zoonotic infection in humans, which typically is a result of bites or scratches from domestic pets...
, and Haemophilus somnus, for treatment of bovine interdigital phlegmon
Phlegmon
Phlegmon is a spreading diffuse inflammatory process with formation of suppurative/purulent exudate or pus. This is the result of acute purulent inflammation which is due to bacterial infection.An example would be phlegmon of diverticulitis...
(foot rot, acute interdigital necrobacillosis, infectious pododermatitis) associated with Fusobacterium necrophorum
Fusobacterium necrophorum
Fusobacterium necrophorum is the species of Fusobacterium that is responsible for Lemierre's syndrome, and appears to be responsible for 10% of all acute sore throats, 21% of all recurring sore throats, and 23% of peritonsillar abscesses with the remainder being caused by Group A streptococci or...
and Bacteroides melaninogenicus
Bacteroides melaninogenicus
Bacteroides melaninogenicus is a normal flora found in the upper respiratory tract. it is an important human pathogen in various anaerobic infections often mixed with other aerobic and anaerobic bacteria....
.
The use of florfenicol in horses, and likely in other equids, typically causes diarrhea. This has been anecdotally reported to progress to lethal cases of acute colitis. Therefore, use of this antimicrobial in the equine patient should be limited to cases in which other, safer, options are not available.