ARF GTPase-activating protein GIT1 is an enzyme

Enzyme

Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...

 that in humans is encoded by the GIT1 gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

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GIT1 contains an ARFGAP domain, Anykrin repeats, and a GRK-interacting domain. The Arf-GAP domain, which enables it to act as a GTPase activating protein (GAP) for the Arf family of GTPases, has been shown to be involved in phosphorylation and inhibition of the ADRB2. If synaptic localization of GIT1 is disturbed, then this is known to affect dendritic spine morphology and formation---this is thought to occur through the Rac1/PAK1/LIMK/CFL1 pathway.

Interactions

GIT1 has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with PLCG1

PLCG1

Phospholipase C, gamma 1, also known as PLCG1, is a protein that in humans is encoded by the PLCG1 gene.-Function:The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate...

, PCLO

PCLO

Protein piccolo is a protein that in humans is encoded by the PCLO gene.-Further reading:...

, Beta adrenergic receptor kinase

Beta adrenergic receptor kinase

Beta adrenergic receptor kinase is a serine/threonine intracellular kinase. It is activated by PKA and its target is the beta adrenergic receptor...

, liprin-alpha-1, PTK2

PTK2

PTK2 protein tyrosine kinase 2 , also known as Focal Adhesion Kinase , is a protein that, in humans, is encoded by the PTK2 gene. PTK2 is a focal adhesion-associated protein kinase involved in cellular adhesion and spreading processes...

, ARHGEF7

ARHGEF7

Rho guanine nucleotide exchange factor 7 is a protein that in humans is encoded by the ARHGEF7 gene.-Interactions:ARHGEF7 has been shown to interact with GIT1, SHANK3, Cbl gene, SHANK1 and SHANK2.-External links:* Info with links in the...

, PPFIA4

PPFIA4

Liprin-alpha-4 is a protein that in humans is encoded by the PPFIA4 gene.-Interactions:PPFIA4 has been shown to interact with ERC2, GIT1 and Nuclear receptor coactivator 2.-Further reading:...

 and GIT2

GIT2

ARF GTPase-activating protein GIT2 is an enzyme that in humans is encoded by the GIT2 gene.-Model organisms: Model organisms have been used in the study of GIT2 function...

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External links

• GIT1 Info with links in the Cell Migration Gateway