Gianotti–Crosti syndrome (also known as "Infantile papular acrodermatitis," "Papular acrodermatitis of childhood," and "Papulovesicular acrolocated syndrome") is a reaction of the skin to a viral infection. Hepatitis B and Epstein-Barr virus

Epstein-Barr virus

The Epstein–Barr virus , also called human herpesvirus 4 , is a virus of the herpes family and is one of the most common viruses in humans. It is best known as the cause of infectious mononucleosis...

 are the most frequently reported etiologies. Other incriminated viruses are hepatitis A

Hepatitis A

Hepatitis A is an acute infectious disease of the liver caused by the hepatitis A virus , an RNA virus, usually spread the fecal-oral route; transmitted person-to-person by ingestion of contaminated food or water or through direct contact with an infectious person...

, hepatitis non A-non B, cytomegalovirus

Cytomegalovirus

Cytomegalovirus is a viral genus of the viral group known as Herpesviridae or herpesviruses. It is typically abbreviated as CMV: The species that infects humans is commonly known as human CMV or human herpesvirus-5 , and is the most studied of all cytomegaloviruses...

, coxsackie

Coxsackie

Coxsackie may refer to:* Coxsackie , New York* Coxsackie , New York* Coxsackievirus -- any of a group of 23 Coxsackie A viruses and 6 Coxsackie B viruses....

, adenovirus, enterovirus

Enterovirus

Enteroviruses are a genus of ssRNA viruses associated with several human and mammalian diseases. Serologic studies have distinguished 66 human enterovirus serotypes on the basis of antibody neutralization tests. Additional antigenic variants have been defined within several of the serotypes on the...

, rotavirus

Rotavirus

Rotavirus is the most common cause of severe diarrhoea among infants and young children, and is one of several viruses that cause infections often called stomach flu, despite having no relation to influenza. It is a genus of double-stranded RNA virus in the family Reoviridae. By the age of five,...

, rubella

Rubella

Rubella, commonly known as German measles, is a disease caused by the rubella virus. The name "rubella" is derived from the Latin, meaning little red. Rubella is also known as German measles because the disease was first described by German physicians in the mid-eighteenth century. This disease is...

, HIV

HIV

Human immunodeficiency virus is a lentivirus that causes acquired immunodeficiency syndrome , a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive...

 and parainfluenza.

It is named for Ferdinando Gianotti and Agostino Crosti

Agostino Crosti

Agostino Crosti , was an Italian dermatologist, and Professor of Dermatology in Milan. Crosti's syndrome and Gianotti-Crosti syndrome are named after him.-References:http://www.whonamedit.com/doctor.cfm/3275.html...

.

Treatment of Gianotti-Crosti syndrome

Gianotti-Crosti disease is harmless and self limited conditions, so no treatment may be required. Treatment is mainly focused on controlling itching, symptomatic relief and and to avoid any further complications. For symptomatic relief from itching, oral antihistamines or any soothing lotions like calamine lotion or zinc oxide may be used. If there are any associated conditions like streptococcal infections, antibiotics may be required.