In enzymology, a glucuronate-2-sulfatase is an enzyme

Enzyme

Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...

 that catalyzes

Catalysis

Catalysis is the change in rate of a chemical reaction due to the participation of a substance called a catalyst. Unlike other reagents that participate in the chemical reaction, a catalyst is not consumed by the reaction itself. A catalyst may participate in multiple chemical transformations....

 the chemical reaction

Chemical reaction

A chemical reaction is a process that leads to the transformation of one set of chemical substances to another. Chemical reactions can be either spontaneous, requiring no input of energy, or non-spontaneous, typically following the input of some type of energy, such as heat, light or electricity...

 of cleaving off the 2-sulfate groups of the 2-O-sulfo-D-glucuronate

Glucuronic acid

Glucuronic acid is a carboxylic acid. Its structure is similar to that of glucose. However, glucuronic acid's sixth carbon is oxidized to a carboxylic acid...

 residues of chondroitin

Chondroitin

Chondroitin is a chondrin derivative.Types include:* Chondroitin sulfate* Dermatan sulfate...

 sulfate, heparin

Heparin

Heparin , also known as unfractionated heparin, a highly sulfated glycosaminoglycan, is widely used as an injectable anticoagulant, and has the highest negative charge density of any known biological molecule...

 and heparitin sulfate.

This enzyme belongs to the family of hydrolase

Hydrolase

In biochemistry, a hydrolase is an enzyme that catalyzes the hydrolysis of a chemical bond. For example, an enzyme that catalyzed the following reaction is a hydrolase:-Nomenclature:...

s, specifically those acting on sulfuric ester

Ester

Esters are chemical compounds derived by reacting an oxoacid with a hydroxyl compound such as an alcohol or phenol. Esters are usually derived from an inorganic acid or organic acid in which at least one -OH group is replaced by an -O-alkyl group, and most commonly from carboxylic acids and...

 bonds. The systematic name of this enzyme class is polysaccharide-2-O-sulfo-D-glucuronate 2-sulfohydrolase. This enzyme is also called glucurono-2-sulfatase. This enzyme participates in glycosaminoglycan degradation and glycan structures - degradation.