HLA-B63
Encyclopedia
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| HLA-B (alpha)-β2MG with bound peptide | ||
| Alleles | *1516, *1517 | |
| Structure (See HLA-B HLA-B HLA-B is a human gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen complex... ) |
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| Shared data | ||
| Locus Locus (genetics) In the fields of genetics and genetic computation, a locus is the specific location of a gene or DNA sequence on a chromosome. A variant of the DNA sequence at a given locus is called an allele. The ordered list of loci known for a particular genome is called a genetic map... |
chr.6 Chromosome 6 (human) Chromosome 6 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 6 spans more than 170 million base pairs and represents between 5.5 and 6% of the total DNA in cells... 6p21.31 |
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HLA-B63 (B63) is an HLA
Human leukocyte antigen
The human leukocyte antigen system is the name of the major histocompatibility complex in humans. The super locus contains a large number of genes related to immune system function in humans. This group of genes resides on chromosome 6, and encodes cell-surface antigen-presenting proteins and...
-B
HLA-B
HLA-B is a human gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen complex...
serotype
Serotype
Serotype or serovar refers to distinct variations within a subspecies of bacteria or viruses. These microorganisms, viruses, or cells are classified together based on their cell surface antigens...
. The serotype identifies certain B*15 gene-allele protein products of HLA-B.
B63 is one of many split antigens of the broad antigen, B15
HLA-B15
HLA-B15 is an HLA-B serotype. The serotype identifies the B*15 gene-allele protein products of HLA-B.B15 is a broad antigen can be subdivided into several split antigens that are often used in characterization. These are B62, B63, B70, B71, B72, B75, B76, B77...
. B63 identifies the B*1516 and B*1517 allele products.
Serotype
| B*15 | B15 | B62 | B63 | B70 | B71 | B72 | B75 | B76 | B77 | Sample |
| allele | % | % | % | % | % | % | % | % | % | size (N) |
| 3 | 80 | 816 | ||||||||
| 2 | 88 | 797 | ||||||||
| Alleles link-out to IMGT/HLA Human leukocyte antigen The human leukocyte antigen system is the name of the major histocompatibility complex in humans. The super locus contains a large number of genes related to immune system function in humans. This group of genes resides on chromosome 6, and encodes cell-surface antigen-presenting proteins and... Databease at EBI European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory... |
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Alleles
| freq | ||
| ref. | Population | (%) |
| Ivory Coast Akan Adiopodoume | 4.6 | |
| Cameroon Bamileke | 3.2 | |
| USA African Americans (3) | 1.9 | |
| Italy South Campania | 1.6 | |
| United Arab Emerates | 1.5 | |
| Brazil | 1.4 | |
| Azores S. Maria and S. Miguel | 1.3 | |
| Zimbabwe Harare Shona | 1.3 | |
| Cameroon Beti | 1.1 | |
| Cameroon Yaounde | 1.1 | |
| Mali Bandiagara | 1.1 | |
| Tunisia Tunis | 1.1 | |
| Kenya Nandi | 1.0 | |
| Cape Verde SE Islands | 0.8 | |
| Kenya | 0.7 | |
| Uganda Kampala | 0.6 | |
| Brazil Belo Horizonte | 0.5 | |
| South Africian Natal Zulu | 0.5 | |
| Sudanese | 0.5 | |
| Tunisia | 0.5 | |
| Kenya Luo | 0.4 | |
| Oman | 0.4 |
| freq | ||
| ref. | Population | (%) |
| India Khandesh Pawra | 9.0 | |
| South Africa Natal Tamil | 3.1 | |
| Saudi Arabia Guraiat and Hail | 2.7 | |
| Mexico Zaptotec Oaxaca | 2.2 | |
| India North Hindus | 1.9 | |
| Bulgaria | 1.8 | |
| India North Delhi | 1.6 | |
| China Inner Mongolia | 1.5 | |
| Georgia Tibilisi Georgians | 1.4 | |
| Kenya Luo | 1.3 | |
| Cuban Mulatto | 1.2 | |
| Brazil Belo Horizonte | 1.1 | |
| Cameroon Yaounde | 1.1 | |
| Portugal North | 1.1 | |
| Tunisia Tunis | 1.1 | |
| Kenya Nandi | 1.0 | |
| Portugal Centre | 1.0 | |
| China Qinghai Hui | 0.9 | |
| Israel Ashk. and Non Ashk.i Jews | 0.9 | |
| Azores Terceira Island | 0.8 | |
| Cape Verde Southeastern Islands | 0.8 | |
| France South East | 0.8 | |
| India New Delhi | 0.8 | |
| Russia Tuva pop 2 | 0.8 | |
| Sudanese | 0.8 | |
| USA African Americans pop3 | 0.8 | |
| USA Caucasian pop2 | 0.8 | |
| Brazil | 0.7 | |
| Cuban White | 0.7 | |
| Thailand | 0.7 | |
| USA Philadelphia Caucasians | 0.7 | |
| Cameroon Beti | 0.6 | |
| Romanian | 0.6 | |
| Czech Republic | 0.5 | |
| Singapore Thai | 0.5 | |
| Spain Eastern Andalusia Gipsy | 0.5 |