HLA-B*1501 (alpha)-β2MG with bound peptide
Alleles	B*1501, 1502 . .
Structure (See HLA-B HLA-B HLA-B is a human gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen complex... )
Shared data
Locus Locus (genetics) In the fields of genetics and genetic computation, a locus is the specific location of a gene or DNA sequence on a chromosome. A variant of the DNA sequence at a given locus is called an allele. The ordered list of loci known for a particular genome is called a genetic map...	chr.6 Chromosome 6 (human) Chromosome 6 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 6 spans more than 170 million base pairs and represents between 5.5 and 6% of the total DNA in cells...  6p21.31

HLA-B15 (B15) is an HLA

Human leukocyte antigen

The human leukocyte antigen system is the name of the major histocompatibility complex in humans. The super locus contains a large number of genes related to immune system function in humans. This group of genes resides on chromosome 6, and encodes cell-surface antigen-presenting proteins and...

-B

HLA-B

HLA-B is a human gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen complex...

 serotype

Serotype

Serotype or serovar refers to distinct variations within a subspecies of bacteria or viruses. These microorganisms, viruses, or cells are classified together based on their cell surface antigens...

. The serotype identifies the B*15 gene-allele protein products of HLA-B.
B15 is a broad antigen can be subdivided into several split antigens that are often used in characterization. These are B62, B63, B70, B71, B72, B75

HLA-B75

HLA-B75 is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.B75 is one of many split antigens of the broad antigen, B15...

, B76, B77

HLA-B77

HLA-B77 is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.B77 is a split antigen of the broad antigen B15.-Serotype:...

. B*15 is the largest allele

Allele

An allele is one of two or more forms of a gene or a genetic locus . "Allel" is an abbreviation of allelomorph. Sometimes, different alleles can result in different observable phenotypic traits, such as different pigmentation...

 grouping for any known human autosomal locus, idenitified as of August 2008 there are more than 150 alleles and ~140 amino acid

Amino acid

Amino acids are molecules containing an amine group, a carboxylic acid group and a side-chain that varies between different amino acids. The key elements of an amino acid are carbon, hydrogen, oxygen, and nitrogen...

 sequence variants from those gene products. Some of these alleles are discussed below. Other alleles, such as B*46

HLA-B46

HLA-B46 is an HLA-B serotype. The serotype identifies the gene products of HLA-B*4601 allele.B*4601 resulted from a rare, interlocus, gene conversion between B62, probably B*1501, and a HLA-C allele. B*4601 is the most common HLA-B allele that does not have an origin within Africa, and estimated...

 evolved from B*15. One reason for the diversity of this group is that B15 is among a group of alleles enriched in the original humans that left Africa and dispersed across East Asia and Australia. As people traveled east the frequency of many alleles dropped or disappeared from migrants. However B*15 persisted, expanded and diversified. The wide range and complex environment selected for new alleles and promoted their expansion. B*46 for example is not found in Africa, and appears to have evolved and spread in East Asia, to several 100 million bearers worldwide.

HLA-B15 allele *1502

HLA-B75

HLA-B75 is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.B75 is one of many split antigens of the broad antigen, B15...

 is associated with the severe skin conditions Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis

Toxic epidermal necrolysis

Toxic epidermal necrolysis is a rare, life-threatening dermatological condition that is usually induced by a reaction to medications...

 (TEN) caused by carbamazepine

Carbamazepine

Carbamazepine is an anticonvulsant and mood-stabilizing drug used primarily in the treatment of epilepsy and bipolar disorder, as well as trigeminal neuralgia...

 drug sensitivity in East Asians.

Serotype

| Allele >

Serotypes B15, B62, B63, B70, B71, B72, B75, B76, B77 recognition of the HLA B*15 gene products

B*15	B15	B62	B63	B70	B71	B72	B75	B76	B77	Sample	Desig-
allele	%	%	%	%	%	%	%	%	%	size (N)	nation
	2	96								1906	B62 HLA-B62 HLA-B62 is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.B62 is largest of many split antigens of the broad antigen, B15. B62 best identifies the B*1501, B*1504, B*1507, and B*1525 allele products....
	7	22					62			1035	B75 HLA-B75 HLA-B75 is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.B75 is one of many split antigens of the broad antigen, B15...
	1			61		10				2569	B70 HLA-B70 HLA-B70 is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.B70 is one of many split antigens of the broad antigen, B15.-Serotype:-Alleles:...
	10	69								29	B62 HLA-B62 HLA-B62 is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.B62 is largest of many split antigens of the broad antigen, B15. B62 best identifies the B*1501, B*1504, B*1507, and B*1525 allele products....
	18	64								22	B62 HLA-B62 HLA-B62 is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.B62 is largest of many split antigens of the broad antigen, B15. B62 best identifies the B*1501, B*1504, B*1507, and B*1525 allele products....
		40		20			11			10	B62 HLA-B62 HLA-B62 is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.B62 is largest of many split antigens of the broad antigen, B15. B62 best identifies the B*1501, B*1504, B*1507, and B*1525 allele products....
		79								101	B62 HLA-B62 HLA-B62 is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.B62 is largest of many split antigens of the broad antigen, B15. B62 best identifies the B*1501, B*1504, B*1507, and B*1525 allele products....
		20					18			45	B62 HLA-B62 HLA-B62 is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.B62 is largest of many split antigens of the broad antigen, B15. B62 best identifies the B*1501, B*1504, B*1507, and B*1525 allele products....
				53						65	B70 HLA-B70 HLA-B70 is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.B70 is one of many split antigens of the broad antigen, B15.-Serotype:-Alleles:...
	1			49	2	2	1			1204	B70 HLA-B70 HLA-B70 is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.B70 is one of many split antigens of the broad antigen, B15.-Serotype:-Alleles:...
	15	27					21			68	B62 HLA-B62 HLA-B62 is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.B62 is largest of many split antigens of the broad antigen, B15. B62 best identifies the B*1501, B*1504, B*1507, and B*1525 allele products....
	17	18						8		12	B62 HLA-B62 HLA-B62 is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.B62 is largest of many split antigens of the broad antigen, B15. B62 best identifies the B*1501, B*1504, B*1507, and B*1525 allele products....
	15	8	19				12		21	116	B77 HLA-B77 HLA-B77 is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.B77 is a split antigen of the broad antigen B15.-Serotype:...
	13	49					28			138	B62 HLA-B62 HLA-B62 is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.B62 is largest of many split antigens of the broad antigen, B15. B62 best identifies the B*1501, B*1504, B*1507, and B*1525 allele products....
	3		80							816	B63 HLA-B63 HLA-B63 is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.B63 is one of many split antigens of the broad antigen, B15. B63 identifies the B*1516 and B*1517 allele products.-Serotype:-Alleles:...
	2		88							797	B63 HLA-B63 HLA-B63 is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.B63 is one of many split antigens of the broad antigen, B15. B63 identifies the B*1516 and B*1517 allele products.-Serotype:-Alleles:...
				51	3					552	B70 HLA-B70 HLA-B70 is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.B70 is one of many split antigens of the broad antigen, B15.-Serotype:-Alleles:...
		100								5	B62 HLA-B62 HLA-B62 is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.B62 is largest of many split antigens of the broad antigen, B15. B62 best identifies the B*1501, B*1504, B*1507, and B*1525 allele products....
	7	12					55			132	B75 HLA-B75 HLA-B75 is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.B75 is one of many split antigens of the broad antigen, B15...
		44								54	B62 HLA-B62 HLA-B62 is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.B62 is largest of many split antigens of the broad antigen, B15. B62 best identifies the B*1501, B*1504, B*1507, and B*1525 allele products....
	7	74					8			116	B62 HLA-B62 HLA-B62 is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.B62 is largest of many split antigens of the broad antigen, B15. B62 best identifies the B*1501, B*1504, B*1507, and B*1525 allele products....
	7	76								76	B62 HLA-B62 HLA-B62 is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.B62 is largest of many split antigens of the broad antigen, B15. B62 best identifies the B*1501, B*1504, B*1507, and B*1525 allele products....
	14	57					14			7	B62 HLA-B62 HLA-B62 is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.B62 is largest of many split antigens of the broad antigen, B15. B62 best identifies the B*1501, B*1504, B*1507, and B*1525 allele products....
				19						21	B70 HLA-B70 HLA-B70 is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.B70 is one of many split antigens of the broad antigen, B15.-Serotype:-Alleles:...
	17	64								98	B62 HLA-B62 HLA-B62 is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.B62 is largest of many split antigens of the broad antigen, B15. B62 best identifies the B*1501, B*1504, B*1507, and B*1525 allele products....
		50								12	B62 HLA-B62 HLA-B62 is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.B62 is largest of many split antigens of the broad antigen, B15. B62 best identifies the B*1501, B*1504, B*1507, and B*1525 allele products....
		79								34	B62 HLA-B62 HLA-B62 is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.B62 is largest of many split antigens of the broad antigen, B15. B62 best identifies the B*1501, B*1504, B*1507, and B*1525 allele products....
				30						34	B70 HLA-B70 HLA-B70 is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.B70 is one of many split antigens of the broad antigen, B15.-Serotype:-Alleles:...
B15	B62	B63	B70	B71	B72	B75	B76	B77	N
Alleles link-out to IMGT/HLA HLA Informatics Group The HLA Informatics Group is a research group at the Anthony Nolan Research Institute that develops, runs and maintains the IMGT /HLA Database and the IPD...  Databease at EBI European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...