HLA-B (alpha)-β2MG with bound peptide
Alleles	B*1513
Structure (See HLA-B HLA-B HLA-B is a human gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen complex... )
Shared data
Locus Locus (genetics) In the fields of genetics and genetic computation, a locus is the specific location of a gene or DNA sequence on a chromosome. A variant of the DNA sequence at a given locus is called an allele. The ordered list of loci known for a particular genome is called a genetic map...	chr.6 Chromosome 6 (human) Chromosome 6 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 6 spans more than 170 million base pairs and represents between 5.5 and 6% of the total DNA in cells...  6p21.31

HLA-B75 (B75) is an HLA

Human leukocyte antigen

The human leukocyte antigen system is the name of the major histocompatibility complex in humans. The super locus contains a large number of genes related to immune system function in humans. This group of genes resides on chromosome 6, and encodes cell-surface antigen-presenting proteins and...

-B

HLA-B

HLA-B is a human gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen complex...

 serotype

Serotype

Serotype or serovar refers to distinct variations within a subspecies of bacteria or viruses. These microorganisms, viruses, or cells are classified together based on their cell surface antigens...

. The serotype identifies certain B*15 gene-allele protein products of HLA-B.
B75 is one of many split antigens of the broad antigen, B15

HLA-B15

HLA-B15 is an HLA-B serotype. The serotype identifies the B*15 gene-allele protein products of HLA-B.B15 is a broad antigen can be subdivided into several split antigens that are often used in characterization. These are B62, B63, B70, B71, B72, B75, B76, B77...

. B75 (B*1502) is associated with a severe drug-induced skin condition in ethnic East Asians.

Serotype

Serotypes B15, B62, B63, B70, B71, B72, B75, B76, B77 recognition of the
HLA B*15 gene products

B*15	B15	B62	B63	B70	B71	B72	B75	B76	B77	Sample
allele	%	%	%	%	%	%	%	%	%	size (N)
	7	22					62			1035
	7	12					55			132
Alleles link-out to IMGT/HLA Human leukocyte antigen The human leukocyte antigen system is the name of the major histocompatibility complex in humans. The super locus contains a large number of genes related to immune system function in humans. This group of genes resides on chromosome 6, and encodes cell-surface antigen-presenting proteins and...  Databease at EBI European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...

Alleles

HLA B*1502 frequencies

		freq
ref.	Population	(%)
	Philippines Ivatan	22.0
	Taiwan Puyuma	18.0
	China Guangxi Maonan	14.8
	China Yunnan Lisu	12.3
	Taiwan Tao	12.0
	Singapore Chinese Han	11.6
	China Guangzhou	11.0
	Hong Kong Chinese	10.2
	China Yunnan Nu	9.0
	Singapore Riau Malay	8.4
	Singapore Javanese Indonesians	8.2
	Thailand (3)	8.2
	China South Han	7.1
	Singapore Thai	6.1
	India Khandesh Pawra	6.0
	Taiwan Minnan pop 1	5.9
	Singapore Chinese	5.7
	India West Bhils	4.0
	Taiwan Pazeh	3.6
	China Guangdong Meizhou Han	3.5
	South Africa Natal Tamil	3.1
	China Qinghai Hui	2.7
	Taiwan Hakka	2.7
	Shijiazhuang Tianjian Han	2.4
	China North Han	1.9
	India Mumbai Marathas	1.9
	India North Delhi	1.6
	China Beijing	1.5
	China Inner Mongolia	1.5
	American Samoa	1.0
	India North Hindus	1.0
	Taiwan Siraya	1.0
	Taiwan Tsou	1.0
	Ingig. Australian Groote Eylandt	0.7
	United Arab Emirates	0.6

HLA B*1521 frequencies

		freq
ref.	Population	(%)
	Indig. Australian Cape York Penin.	13.5
	Indig. Australian Yuendumu	12.4
	PNG Eastern Highlands Goroka	7.1
	Ind. Australian Groote Eylandt	6.0
	New Caledonia	5.8
	Singapore Riau Malay	4.0
	American Samoa	3.0
	Australian Aborigine Kimberly	2.6
	PNG Karimui Plateau	2.5
	Singapore Javanese Indonesians	2.0
	Papua New Guinea Wanigela	1.5
	USA Asian	1.4
	Philippines Ivatan	1.0
	Thailand (3)	1.0
	Taiwan Hakka	0.9

Diseases

HLA-B*1502 is associated with Carbamazepine

Carbamazepine

Carbamazepine is an anticonvulsant and mood-stabilizing drug used primarily in the treatment of epilepsy and bipolar disorder, as well as trigeminal neuralgia...

 and phenytoin

Phenytoin

Phenytoin sodium is a commonly used antiepileptic. Phenytoin acts to suppress the abnormal brain activity seen in seizure by reducing electrical conductance among brain cells by stabilizing the inactive state of voltage-gated sodium channels...

 induced Stevens–Johnson syndrome in Chinese and Thai. One study showed a 100% association between B*1502 and the drug induced skin disorder in Chinese. In Europe the B*1502 positive patients are only found in this syndrome of persons of East Asian descent, however B58

HLA-B58

HLA-B58 is an HLA-B serotype. B58 is a split antigen from the B17 broad antigen, the sister serotype B57. The serotype identifies the more common HLA-B*58 gene products...

 confers susceptibility to both groups but to a lesser degree and is sensitive to allopurinol

Allopurinol

Allopurinol is a drug used primarily to treat hyperuricemia and its complications, including chronic gout.- Mechanism of action :...

.