HLA-DR14
Encyclopedia
 |
|
| Haplotypes groups | DRA*01:DRB1*1401 DRA*01:DRB1*1402 DRA*01:DRB1*1403 DRA*01:DRB1*1404 .... |
| Structure (See HLA-DR) | |
| Identifiers | |
| Symbol(s) Human Genome Organisation The Human Genome Organisation is an organization involved in the Human Genome Project, a project about mapping the human genome. HUGO was established in 1989 as an international organization, primarily to foster collaboration between genome scientists around the world... |
HLA-DRA |
| EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory... |
DRA*0101 |
| Identifiers | |
| Symbol(s) Human Genome Organisation The Human Genome Organisation is an organization involved in the Human Genome Project, a project about mapping the human genome. HUGO was established in 1989 as an international organization, primarily to foster collaboration between genome scientists around the world... |
HLA-DRB1 |
| EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory... |
DRB1*1401 |
| EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory... |
DRB1*1402 |
| EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory... |
DRB1*1403 |
| EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory... |
DRB1*1404 |
| EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory... |
DRB1*1405 |
| EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory... |
DRB1*1406 |
| Shared data | |
| Locus Locus (genetics) In the fields of genetics and genetic computation, a locus is the specific location of a gene or DNA sequence on a chromosome. A variant of the DNA sequence at a given locus is called an allele. The ordered list of loci known for a particular genome is called a genetic map... |
chr.6 Chromosome 6 (human) Chromosome 6 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 6 spans more than 170 million base pairs and represents between 5.5 and 6% of the total DNA in cells... 6p21.31 |
HLA-DR14(DR14) is a HLA
Human leukocyte antigen
The human leukocyte antigen system is the name of the major histocompatibility complex in humans. The super locus contains a large number of genes related to immune system function in humans. This group of genes resides on chromosome 6, and encodes cell-surface antigen-presenting proteins and...
-DR serotype that recognizes the DRB1*1401 to *1408, *1410 to *1418, and other *14 gene products. DR14 serotype is a split antigen of the older HLA-DR6
HLA-DR6
HLA-DR6 is a broad-antigen serotype that is further split into HLA-DR13 and HLA-DR14 antigen serotypes.-Serology:DR6 serological reactivity is relatively poor compared to other serological tests for DR antigens. Compare to DQ2 or DR7....
serotype group which also contains the similar HLA-DR13
HLA-DR13
HLA-DR13 is a HLA-DR serotype that recognizes the DRB1*1301 to *13082, *1310 and some other *13 gene products. DR13 serotype is a split antigen of the older HLA-DR6 serotype group which also contains the similar HLA-DR14 antigens.-Alleles:...
antigens.
Alleles
| DRB1* | DR14 | DR6 | DR13 | Sample |
| allele | % | % | % | size (N) |
| 1401 | 74 | 14 | 3 | 1942 |
| 1402 | 61 | 13 | 9 | 204 |
| 1403 | 72 | 12 | 2 | 37 |
| 1404 | 79 | 8 | 80 | |
| 1405 | 86 | 10 | 58 | |
| 1406 | 37 | 15 | 22 | 117 |
| 1407 | 90 | 10 | ||
| 1408 | 25 | 4 | ||
| 1410 | >75 | 4 | ||
Serotypes are unknown the following alleles: DRB1**1409, *1419 to *1462
Extended linkage
DR*14:DQ5 haplotype: increased risk for non-AChR autoantibodies in myasthenia gravis.Genetic Linkage
| DRA | DRB1 | | DRB3 | |
|---|---|---|---|
| DR14(6)-DR52 | *0101 | *1401 | *0201 |
| *0101 | *1402 | *0201 | |
| *0101 | *1403 | *0101 | |
| DQA1 | DQB1 | | DRB1 | |
| DR14-DQ5(5.3, 1) | *0104 | *0503 | *1401 |
| HLA-A | HLA-B | | DRB1 | |
| A11-B35-DR14(6) | *1101 | *3501 | *1401 |
| A2-B51(5)-DR14(6) | *0201 | *5101 | *1401 |
HLA-DR13 is genetically linked to HLA-DR52
HLA-DR52
HLA-DR52 is an HLA-DR serotype that recognizes gene products of HLA-DRB3 locus. There are 3 allele groups that can produce 35 isoforms.DRB3, DRB4, and DRB5 are minor DR beta encoding loci, they have been recognized as having distinct evolution...
and HLA-DQ5
HLA-DQ5
HLA-DQ4 is a human leukocyte antigen serotype subgroup within HLA-DQ serotypes. The serotype is determined by the antibody recognition of β5.x subset of DQ β-chains. The β-chain of DQ is encoded by HLA-DQB1 locus and DQ5 are encoded by the HLA-DQB1*05 allele group. This group currently contains 4...
(HLA-DQ1
HLA-DQ1
HLA-DQ1 is a serotype that covers a broad range of HLA-DQ haplotypes. Historically it was identified as a DR-like alpha chain called DC1, later, it was among 3 types DQw1 , DQw2 and DQw3. Of these three serotyping specificities only DQw1 recognized DQ alpha chain. The serotype is positive in...
) serotypes.