HLA-DR13
Encyclopedia
Haplotypes groups | DQA*01:DRB1*1301 to DQA*01:DRB1*1309 DQA*01:DRB1*1310 DQA*01:DRB1*1312 .... |
Structure (See HLA-DR) | |
Identifiers | |
Symbol(s) Human Genome Organisation The Human Genome Organisation is an organization involved in the Human Genome Project, a project about mapping the human genome. HUGO was established in 1989 as an international organization, primarily to foster collaboration between genome scientists around the world... |
HLA-DRA |
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory... |
DRA*0101 |
Identifiers | |
Symbol(s) Human Genome Organisation The Human Genome Organisation is an organization involved in the Human Genome Project, a project about mapping the human genome. HUGO was established in 1989 as an international organization, primarily to foster collaboration between genome scientists around the world... |
HLA-DRB1 |
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory... |
DRB1*1301 |
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory... |
DRB1*1302 |
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory... |
DRB1*1304 |
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory... |
DRB1*1306 |
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory... |
DRB1*1307 |
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory... |
DRB1*1310 |
Shared data | |
Locus Locus (genetics) In the fields of genetics and genetic computation, a locus is the specific location of a gene or DNA sequence on a chromosome. A variant of the DNA sequence at a given locus is called an allele. The ordered list of loci known for a particular genome is called a genetic map... |
chr.6 Chromosome 6 (human) Chromosome 6 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 6 spans more than 170 million base pairs and represents between 5.5 and 6% of the total DNA in cells... 6p21.31 |
HLA-DR13(DR13) is a HLA
Human leukocyte antigen
The human leukocyte antigen system is the name of the major histocompatibility complex in humans. The super locus contains a large number of genes related to immune system function in humans. This group of genes resides on chromosome 6, and encodes cell-surface antigen-presenting proteins and...
-DR serotype that recognizes the DRB1*1301 to *13082, *1310 and some other *13 gene products. DR13 serotype is a split antigen of the older HLA-DR6
HLA-DR6
HLA-DR6 is a broad-antigen serotype that is further split into HLA-DR13 and HLA-DR14 antigen serotypes.-Serology:DR6 serological reactivity is relatively poor compared to other serological tests for DR antigens. Compare to DQ2 or DR7....
serotype group which also contains the similar HLA-DR14
HLA-DR14
HLA-DR14 is a HLA-DR serotype that recognizes the DRB1*1401 to *1408, *1410 to *1418, and other *14 gene products. DR14 serotype is a split antigen of the older HLA-DR6 serotype group which also contains the similar HLA-DR13 antigens.-Alleles:...
antigens.
Alleles
DRB1* | DR13 | DR6 | DR14 | Sample |
allele | % | % | % | size (N) |
1301 | 81 | 14 | 1 | 3788 |
1302 | 74 | 17 | 2 | 3081 |
1303 | 69 | 10 | 2 | 948 |
1304 | 87 | 127 | ||
1305 | 54 | 12 | 305 | |
1306 | 78 | 9 | ||
1307 | >50 | 1 | ||
1308 | 45 | 55 | 9 | |
1310 | >75 | 5 | ||
Serotypes are unknown the following alleles: DRB1*1309, *1315 to *1379
DRB1*13 allele group
- 81 Alleles: 74 proteins
- DR13 (weak or no DR6) Serotype: *1301, *1302, *1304, *1306, *1307, *1310, *1312 to *1314
- DR6 (weak DR13) Serotype: *1308
- DR13&Other serotypes: *1303, *1305, *1311,
- Serotype unknown: *1309, *1315 to *1374
Disease associations
DRB1*1302 is linked to early childhood myastenia gravis. Alleles of DR13 along with immunization for hepatitis B and C are most protective against the disease.Genetic Linkage
DRA | DRB1 | | DRB3 | |
---|---|---|---|
DR13(6)-DR52 | *0101 | *1301 | *0101 |
*0101 | *1301 | *0201 | |
*0101 | *1302 | *0301 | |
DQA1 | DQB1 | | DRB1 | |
DR13(6)-DQ6(6.3, 1) | *0103 | *0603 | *1301 |
DR13(6)-DQ6(6.4, 1) | *0102 | *0604 | *1302 |
DR13(6)-DQ6(6.5, 1) | *0102 | *0605 | *1302 |
DR13(6)-DQ6(6.9, 1) | *0102 | *0609 | *1302 |
HLA-A | HLA-B | | DRB1 | |
A2-Cw5-B44(16)-DR13 | *02 | *4402 | *1301 |
HLA-DR13 is genetically linked to DR52 and HLA-DQ6
HLA-DQ6
HLA-DQ6 is a human leukocyte antigen serotype within HLA-DQ serotype group. The serotype is determined by the antibody recognition of β6 subset of DQ β-chains. The β-chain of DQ isoforms are encoded by HLA-DQB1 locus and DQ6 are encoded by the HLA-DQB1*06 allele group. This group currently...
(HLA-DQ1
HLA-DQ1
HLA-DQ1 is a serotype that covers a broad range of HLA-DQ haplotypes. Historically it was identified as a DR-like alpha chain called DC1, later, it was among 3 types DQw1 , DQw2 and DQw3. Of these three serotyping specificities only DQw1 recognized DQ alpha chain. The serotype is positive in...
) serotypes.