Haplotypes groups	DRA*01:DRB1*0301 DRA*01:DRB1*0304
Structure (See HLA-DR)
Identifiers
Symbol(s) Human Genome Organisation The Human Genome Organisation is an organization involved in the Human Genome Project, a project about mapping the human genome. HUGO was established in 1989 as an international organization, primarily to foster collaboration between genome scientists around the world...	HLA-DRA
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	DRA*0101
Identifiers
Symbol(s) Human Genome Organisation The Human Genome Organisation is an organization involved in the Human Genome Project, a project about mapping the human genome. HUGO was established in 1989 as an international organization, primarily to foster collaboration between genome scientists around the world...	HLA-DRB1
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	DRB1*0301
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	DRB1*0304
Shared data
Locus Locus (genetics) In the fields of genetics and genetic computation, a locus is the specific location of a gene or DNA sequence on a chromosome. A variant of the DNA sequence at a given locus is called an allele. The ordered list of loci known for a particular genome is called a genetic map...	chr.6 Chromosome 6 (human) Chromosome 6 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 6 spans more than 170 million base pairs and represents between 5.5 and 6% of the total DNA in cells...  6p21.31

HLA-DR17 (DR17) is an HLA

Human leukocyte antigen

The human leukocyte antigen system is the name of the major histocompatibility complex in humans. The super locus contains a large number of genes related to immune system function in humans. This group of genes resides on chromosome 6, and encodes cell-surface antigen-presenting proteins and...

-DR serotype that recognizes the DRB1*0301 and *0304 gene products. DR17 is found at high frequency in Western Europe (such as Western Ireland, N. Spain, Sardinia). DR17 is part of the broader antigen group HLA-DR3

HLA-DR3

HLA-DR3 is composed to the HLA-DR17 and HLA-DR18 split 'antigens' serotypes. DR3 is a component gene-allele of the AH8.1 haplotype in Northern and Western Europeans. Genes between B8 and DR3 on this haplotype are frequently associated with autoimmune disease....

 and is very similar to the group HLA-DR18

HLA-DR18

HLA-DR18 is a HLA-DR serotype that recognizes the DRB1*0302 and *0303 gene products. Compared to DR17 which is found at high frequency in Western Europe, DR18 is found more in SE Europe and Central Asia.-Serology:...

.

Serology

DR17 and DR3 recognition of some DRB1*03 alleles

DRB1*	DR17	DR3	DR18	Sample
allele	%	%	%	size (N)
0301	64	33	0	9698
0304	20	60		5

DR17 recognizes the DRB1*0301, *0304 alleles.

By serotype

DR17 is associated with non-chronic sarcoidosis, infantile spasm/epilepsy, rabies vaccine-induced autoimmune encephalomyelitis and cardiovascular hypertrophy in subjects with arterial hypertension People with DR17 show a tendency toward benzylpenicilloyl allergies.

By allele

DRB1*0301: diabetes mellitus type 1

Diabetes mellitus type 1

Diabetes mellitus type 1 is a form of diabetes mellitus that results from autoimmune destruction of insulin-producing beta cells of the pancreas. The subsequent lack of insulin leads to increased blood and urine glucose...

, myositis, early onset Graves disease, type 1 autoimmune hepatitis, inflammatory inclusion body myositis. In autoimmune hepatitis,
DRB1*0301 correlates with more severe and difficult to treat disease.

By haplotype

DRB1*0301:DQA1*05:DQB1*0201 is associated with diabetes mellitus type 1

Diabetes mellitus type 1

Diabetes mellitus type 1 is a form of diabetes mellitus that results from autoimmune destruction of insulin-producing beta cells of the pancreas. The subsequent lack of insulin leads to increased blood and urine glucose...

, ovarian cancer, non-thymomic myasthenia gravis, idiopathic inflammatory myopathies, non-cancer associated Lambert-Eaton myasthenic syndrome and sarcoidosis

By phenotype

The DRB1*0301/DRB1*1501 heterozygote is linked to primary Sjögren's syndrome
Genetic Linkage=

Serotypes	DRA	DRB1	DRB3
DR17	*0101	*0301	0101
	*0101	*0301	0201
Serotypes	DQA1	DQB1	| DRB1
DR17(3)-DQ2(2.5)	*0501	*0201	*0301
Serotypes	HLA-A	HLA C	HLA B	| DRB1
A1-Cw7-B8-DR17(3)	*0101	*0701	*0801	*0301
A2-Cw7-B8-DR17(3)	*0201	*0701	*0801	*0301
A30-Cw5-B18-DR17(3)	*3002	*0501	*1801	*0301

HLA-DR17 is genetically linked to DR52 and HLA-DQ2 serotypes. These serotypes
are the result of gene products from the HLA-DRB3* and HLA DQA1*0501 and HLA DQB1*0201 alleles.
DRB1*0301 is frequently within by the "Super-B8" or ancestral HLA haplotype:

A*0101 : Cw*0701 : B*0801 : DRB1*0301 : DQA1*0501 : DQB1*0201

This haplotype is known as "Super B8", "European ancestral haplotype", or "AH8.1"