HLA-DR5 is a broad-antigen serotype that is further split into HLA-DR11

HLA-DR11

HLA-DR11 is a HLA-DR serotype that recognizes the DRB1*1101 to *1110. DR11 serotype is a split antigen of the older HLA-DR5 serotype group which also contains the similar HLA-DR12 antigens.-Serology:...

and HLA-DR12

HLA-DR12

HLA-DR12 is a HLA-DR serotype that recognizes the DRB1*1201 to *1203, *1206. DR12 serotype is a split antigen of the older HLA-DR5 serotype group which also contains the similar HLA-DR11 antigens.-Serology:...

antigen serotypes.

Serology

DR11, DR5 and DR12 recognition of the gene products of some DRB1*11 and DRB1*12 alleles

DRB1*	DR11	DR5	DR12	Sample
allele	%	%	%	size (N)
1101	92	5		3474
1102	89	3		430
1103	89	4		397
1104	87	4		2119
1105	75			4
1106	20	73		15
1107	>50			1
1108	>50			2
1109	80	20		5
				.
	DR12	DR5	DR11	Sample
1201	83	4	2	893
1202	89			162
1203	>50			3
1206	>50			2

With the exception of a few DRB1* alleles the reactivity of DR5 is relatively poor.

Disease associations

DR5 is associated with persistent generalized lymphadenopathy

Lymphadenopathy

Lymphadenopathy is a term meaning "disease of the lymph nodes." It is, however, almost synonymously used with "swollen/enlarged lymph nodes". It could be due to infection, auto-immune disease, or malignancy....

 (PGL) and Kaposi sarcoma in AIDS, juvenile rheumatoid arthritis, pernicious anemia, Hashimoto's thyroiditis

Hashimoto's thyroiditis

Hashimoto's thyroiditis or chronic lymphocytic thyroiditis is an autoimmune disease in which the thyroid gland is gradually destroyed by a variety of cell- and antibody-mediated immune processes. It was the first disease to be recognized as an autoimmune disease...

, mycosis fungoides, polyglandular deficiency syndrome, systemic sclerosis, childhood epilepsy, early-onset alopecia areata

Alopecia areata

Alopecia areata is a medical condition in which hair is lost from some or all areas of the body, usually from the scalp. Because it causes bald spots on the scalp, especially in the first stages, it is sometimes called spot baldness. In 1–2% of cases, the condition can spread to the entire scalp ...

, short-ragweed Ra6 allergy, primary antiphospholipid syndrome, and increased longevity in the Dutch

Genetic linkage

HLA-DR5 reactive gene products are linked to serology of HLA-DRB3 (HLA-DR52

HLA-DR52

HLA-DR52 is an HLA-DR serotype that recognizes gene products of HLA-DRB3 locus. There are 3 allele groups that can produce 35 isoforms.DRB3, DRB4, and DRB5 are minor DR beta encoding loci, they have been recognized as having distinct evolution...

).