Idursulfase
Encyclopedia
Idursulfase is a drug used to treat Hunter syndrome
(also called Mucopolysaccharoidosis II). It is a purified form of the lysosomal
enzyme
iduronate-2-sulfatase
and is produced by recombinant DNA technology in a human cell line.
It is one of the most expensive drugs ever produced, costing $375,000 per year.
It is manufactured by Shire Pharmaceuticals Group
.
Hunter syndrome
Hunter syndrome, or mucopolysaccharidosis Type II, is a lysosomal storage disease caused by a deficient enzyme, iduronate-2-sulfatase . The syndrome is named after physician Charles A. Hunter , who first described it in 1917...
(also called Mucopolysaccharoidosis II). It is a purified form of the lysosomal
Lysosome
thumb|350px|Schematic of typical animal cell, showing subcellular components. [[Organelle]]s: [[nucleoli]] [[cell nucleus|nucleus]] [[ribosomes]] [[vesicle |vesicle]] rough [[endoplasmic reticulum]]...
enzyme
Enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
iduronate-2-sulfatase
Iduronate-2-sulfatase
Iduronate-2-sulfatase is a sulfatase enzyme associated with Hunter syndrome.-External links:* -See also:* Idursulfase...
and is produced by recombinant DNA technology in a human cell line.
It is one of the most expensive drugs ever produced, costing $375,000 per year.
It is manufactured by Shire Pharmaceuticals Group
Shire Pharmaceuticals Group
Shire Plc is a Jersey-registered, Irish-headquartered manufacturer of pharmaceuticals. Originating in and with a large operational base in the United Kingdom, its brands and products include Adderall XR, Carbatrol, Fosrenol, and the recently released Vyvanse....
.