Inotuzumab ozogamicin is a humanize

Humanize

Humanize may refer to:*Humanize a 2001 album by the British jazz/funk band Big Boss Man*Humanized antibody, a type of monoclonal antibody...

d monoclonal antibody for the treatment of cancers. The monoclonal antibody (for CD22

CD22

CD22 or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells...

) is linked to a cytotoxic agent from the class of calicheamicin

Calicheamicin

The calicheamicins are a class of enediyne antibiotics derived from the bacterium Micromonospora echinospora, with calicheamicin γ1 being the most notable. It was isolated originally from a rock collected by a Scripps Research Institute chemist while hiking in Waco, Texas. It is extremely toxic to...

s (which is reflected by 'ozogamicin

Ozogamicin

The term ozogamicin in the names of monoclonal antibodies or antibody-drug conjugates indicates that they are linked to a cytotoxic agent from the class of calicheamicins, as in:*Gemtuzumab ozogamicin*Inotuzumab ozogamicin...

' in the drug's name).

This drug was developed by Wyeth

Wyeth

Wyeth, formerly one of the companies owned by American Home Products Corporation , was a pharmaceutical company. The company was based in Madison, New Jersey, USA...

.

It is undergoing numerous clinical trials, including two phase II trials for Non-Hodgkin lymphoma

Non-Hodgkin lymphoma

The non-Hodgkin lymphomas are a diverse group of blood cancers that include any kind of lymphoma except Hodgkin's lymphomas. Types of NHL vary significantly in their severity, from indolent to very aggressive....

. A phase III trial has been terminated.