Ozogamicin
Encyclopedia
The term ozogamicin in the names of monoclonal antibodies
or antibody-drug conjugate
s indicates that they are linked to a cytotoxic agent from the class of calicheamicin
s, as in:
Monoclonal antibodies
Monoclonal antibodies are monospecific antibodies that are the same because they are made by identical immune cells that are all clones of a unique parent cell....
or antibody-drug conjugate
Antibody-drug conjugate
Antibody-drug conjugates are a new type of targeted therapy, used for example for cancer. They consist of an antibody linked to a payload drug . Hence, they are a type of immunoconjugate and often an immunotoxin.The antibody causes the ADC to bind to the target cancer cells...
s indicates that they are linked to a cytotoxic agent from the class of calicheamicin
Calicheamicin
The calicheamicins are a class of enediyne antibiotics derived from the bacterium Micromonospora echinospora, with calicheamicin γ1 being the most notable. It was isolated originally from a rock collected by a Scripps Research Institute chemist while hiking in Waco, Texas. It is extremely toxic to...
s, as in:
- Gemtuzumab ozogamicinGemtuzumab ozogamicinGemtuzumab ozogamicin is a drug-linked monoclonal antibody that was used to treat acute myelogenous leukemia from 2000-2010...
- Inotuzumab ozogamicinInotuzumab ozogamicinInotuzumab ozogamicin is a humanized monoclonal antibody for the treatment of cancers. The monoclonal antibody is linked to a cytotoxic agent from the class of calicheamicins ....