Intermediate trophoblast
Encyclopedia
Intermediate trophoblast is a distinct subtype of trophoblast
Trophoblast
Trophoblasts are cells forming the outer layer of a blastocyst, which provide nutrients to the embryo and develop into a large part of the placenta. They are formed during the first stage of pregnancy and are the first cells to differentiate from the fertilized egg...

ic tissue that arises from the cytotrophoblast
Cytotrophoblast
The cytotrophoblast is the inner layer of the trophoblast, interior to the syncytiotrophoblast in an embryo.Cytotrophoblast is considered to be the trophoblastic stem cell; it differentiates into the other forms of trophoblastic tissue .-External links: - "Female Reproductive System: placental...

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It is sub-categorized by location:
  • Implantation site intermediate trophoblast
  • Villous intermediate trophoblast
  • Chorionic-type intermediate trophoblast

Function

The function of the implantation site intermediate trophoblast is to anchor the placenta
Placenta
The placenta is an organ that connects the developing fetus to the uterine wall to allow nutrient uptake, waste elimination, and gas exchange via the mother's blood supply. "True" placentas are a defining characteristic of eutherian or "placental" mammals, but are also found in some snakes and...

 to the maternal tissue.

Pathology

Intermediate trophoblasts are thought to be the cell of origin for:
  • Exaggerated placental site (EPS)
  • Placental site nodule (PSN)
  • Placental site trophoblastic tumour (PSTT)
  • Epithelioid trophoblastic tumour (ETT)
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