Intravascular large B-cell lymphoma, abbreviated ILBCL and also referred to as angiotropic large-cell lymphoma, intralymphatic lymphomatosis, intravascular lymphomatosis,, and, less specifically intravascular lymphoma

Intravascular lymphoma

Intravascular lymphoma, also referred to as angiotropic large cell lymphoma,, intralymphatic lymphomatosis, intravascular lymphomatosis,, and "Malignant angioendotheliomatosis", is a condition that may present with variable symptoms, including...

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Diagnosis

ILBCL is a condition that may present with non-specific symptoms and, thus, may be difficult to diagnose in a timely manner.

Presentations may include non-specific cutaneous lesions, and/or CNS involvement.

The diagnosis is established by the examination of tissue

Tissue (biology)

Tissue is a cellular organizational level intermediate between cells and a complete organism. A tissue is an ensemble of cells, not necessarily identical, but from the same origin, that together carry out a specific function. These are called tissues because of their identical functioning...

 under the microscope

Microscope

A microscope is an instrument used to see objects that are too small for the naked eye. The science of investigating small objects using such an instrument is called microscopy...

 (i.e. biopsy

Biopsy

A biopsy is a medical test involving sampling of cells or tissues for examination. It is the medical removal of tissue from a living subject to determine the presence or extent of a disease. The tissue is generally examined under a microscope by a pathologist, and can also be analyzed chemically...

 or autopsy

Autopsy

An autopsy—also known as a post-mortem examination, necropsy , autopsia cadaverum, or obduction—is a highly specialized surgical procedure that consists of a thorough examination of a corpse to determine the cause and manner of death and to evaluate any disease or injury that may be present...

) and immunohistochemical stain

Immunohistochemistry

Immunohistochemistry or IHC refers to the process of detecting antigens in cells of a tissue section by exploiting the principle of antibodies binding specifically to antigens in biological tissues. IHC takes its name from the roots "immuno," in reference to antibodies used in the procedure, and...

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History

It used to be known as malignant angioendotheliomatosis, as it was once thought to arise from the endothelium

Endothelium

The endothelium is the thin layer of cells that lines the interior surface of blood vessels, forming an interface between circulating blood in the lumen and the rest of the vessel wall. These cells are called endothelial cells. Endothelial cells line the entire circulatory system, from the heart...

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