Isocitrate—homoisocitrate dehydrogenase
Encyclopedia
Isocitrate—homoisocitrate dehydrogenase is an enzyme
that catalyzes the following two reactions:
Enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
that catalyzes the following two reactions:
- isocitrateIsocitric acidIsocitric acid is a protonated form of isocitrate, which is a substrate of the citric acid cycle. Isocitrate is formed from citrate with the help of the enzyme aconitase, and is acted upon by isocitrate dehydrogenase...
+ NAD+Nicotinamide adenine dinucleotideNicotinamide adenine dinucleotide, abbreviated NAD, is a coenzyme found in all living cells. The compound is a dinucleotide, since it consists of two nucleotides joined through their phosphate groups. One nucleotide contains an adenine base and the other nicotinamide.In metabolism, NAD is involved...
2-oxoglutarate + CO2 + NADHNicotinamide adenine dinucleotideNicotinamide adenine dinucleotide, abbreviated NAD, is a coenzyme found in all living cells. The compound is a dinucleotide, since it consists of two nucleotides joined through their phosphate groups. One nucleotide contains an adenine base and the other nicotinamide.In metabolism, NAD is involved... - homoisocitrate + NAD+
2-oxoadipateAlpha-ketoadipic acidα-Ketoadipic acid is an intermediate in the metabolism of lysine.-References:...
+ CO2 + NADH + H+