John Kappler
Encyclopedia
John W. Kappler is a professor in the Department of Integrated Immunology at National Jewish Health
. His principal research is in T cell biology
, a subject he collaborates on with his wife Philippa Marrack
. In 1983 they discovered the T cell receptor
, together with Ellis Reinherz and James Allison.
National Jewish Medical and Research Center
National Jewish Health is a research institute located in Denver, Colorado specializing in respiratory, immune and allergic research and treatment. It was founded in 1899 to treat tuberculosis, and is today considered one of the world's best medical research and treatment centers...
. His principal research is in T cell biology
T cell
T cells or T lymphocytes belong to a group of white blood cells known as lymphocytes, and play a central role in cell-mediated immunity. They can be distinguished from other lymphocytes, such as B cells and natural killer cells , by the presence of a T cell receptor on the cell surface. They are...
, a subject he collaborates on with his wife Philippa Marrack
Philippa Marrack
Philippa "Pippa" Marrack FRS is an English biologist, based in the United States, best-known for her research into T cell development, T cell apoptosis and survival, adjuvants, autoimmune disease, and for identifying superantigens, the mechanism behind toxic shock syndrome. She collaborates with...
. In 1983 they discovered the T cell receptor
T cell receptor
The T cell receptor or TCR is a molecule found on the surface of T lymphocytes that is responsible for recognizing antigens bound to major histocompatibility complex molecules...
, together with Ellis Reinherz and James Allison.
Awards
- 1986 - Appointed Investigator, Howard Hughes Medical InstituteHoward Hughes Medical InstituteHoward Hughes Medical Institute is a United States non-profit medical research organization based in Chevy Chase, Maryland. It was founded by the American businessman Howard Hughes in 1953. It is one of the largest private funding organizations for biological and medical research in the United...
- 1989 - Elected member, National Academy of SciencesUnited States National Academy of SciencesThe National Academy of Sciences is a corporation in the United States whose members serve pro bono as "advisers to the nation on science, engineering, and medicine." As a national academy, new members of the organization are elected annually by current members, based on their distinguished and...
- 1993 - Cancer Research Institute William B. Coley AwardWilliam B. Coley AwardThe William B. Coley Award for Distinguished Research in Basic and Tumor Immunology is presented annually by the Cancer Research Institute, Inc., to scientists who have made outstanding achievements in the fields of basic and tumor immunology and whose work has deepened our understanding of the...
- 1994 - Louisa Gross Horwitz PrizeLouisa Gross Horwitz PrizeLouisa Gross Horwitz Prize for Biology or Biochemistry is an annual prize awarded by Columbia University to a researcher or group of researchers that have made an outstanding contribution in basic research in the fields of biology or biochemistry....
for Biology or Biochemistry