Laurie Glimcher
Encyclopedia
Laurie H. Glimcher, a member of the National Academy of Sciences
, is the incoming Dean of the Weill Cornell Medical College. She will succeed Antonio M. Gotto Jr.
in January 2012.
Glimcher is Irene Heinz Given Professor of Immunology at the Harvard School of Public Health
, and Professor of Medicine at Harvard Medical School
. and is a specialist in osteoporosis
. She received her bachelors degree from Radcliffe College
in 1972 and her M.D. from Harvard in 1976.
Her research, according to her biography at Harvard, "uses biochemical and genetic approaches to elucidate the molecular pathways that regulate CD4
T helper cell development and activation. ... The Glimcher laboratory defined the genetic bases of both IL-4 and IFNg expression in T cells. They identified the proto-oncogene c-maf as the transcription factor
responsible for Th2-specific IL-4 expression [and]...discovered the first Th1-specific transcription factor, T-bet and demonstrated that this single factor is a master-regulator of IFNg gene expression and the Th1 phenotype."
She is reported by the Chronicle of Higher Education to have " extensive ties to two pharmaceutical companies, Merck
and Bristol-Myers Squibb
.
According to the New York Times, since 1997 she has been on the Board of Bristol-Myers Squibb
, and "received $244,5000 in compensation for 2010" and "1.4 million in deferred share units" Her research at Harvard has been paritally funded by a three-year contract with Merck, "the company that makes Fosamax". She is also on the Board of the Waters Corporation
, af lab equipment manufacturer. In this article, she "defended her outside interests, saying they presented no conflict as long as they were transparent. She said she wanted to 'leverage the strengths of everyone,' whether scientists, pharmaceutical companies or biotechnology
companies. 'There should be no silos between all of these different strengths,' "
She was honored by a symposium at Harvard on April 15, 2011, titled " “A Commitment to Lineage: A Symposium in Celebration of Laurie Glimcher,.
Ho I-C, Hodge MR, Rooney JW, Glimcher LH. 1996. The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4. Cell
85:973-83.
Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman GC, Glimcher LH. 2000. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100:655-69.
Reimold AM, Iwakoshi NN, Manis J, Vallabhajosyula P, Szomolanyi-Tsuda E, Gravallese EM, Friend D, Grusby MJ, Alt F, Glimcher LH. 2001. Plasma cell differentiation requires transcription factor XBP-1. Nature
412:300-7.
Szabo SJ, Sullivan BM, Stemmann C, Satoskar AR, Sleckman BP, Glimcher LH. 2002. Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science
295:338-42.
Finotto S, Neurath MF, Glickman JN, Qin S, Lehr HA, Green FH, Ackerman K, Haley K, Galle PR, Szabo SJ, Drazen JM, De Sanctis GT, Glimcher LH. 2002. Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science 295:336-8.
Maldonado RA, Irvine DJ, Schreiber R, Glimcher LH. 2004. A role for the immunological synapse in lineage commitment of CD4 lymphocytes. Nature 431:527-32.
Hwang ES, Szabo SJ, Schwartzberg PL, Glimcher LH. 2005. T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science 307:430-3.
Wang J, Fathman JW, Lugo-Villarino G, von Andrian U, Dorfman DM, Glimcher LH. 2006. Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells. Journal of Clinical Investigation
16(2):414-21.
Jones DC, Wein MN, Oukka M, Hofstaetter JG, Glimcher MJ, Glimcher LH. 2006. Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3. Science 312(5777):1223-7.
Garrett W, Lord GM, Punit S, Lugo G, Mazmanian S, Ito S, Glickman J, Glimcher LH. 2007. Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell 131:33-45.
Lee Ah, Scapa EF, Cohen DE, Glimcher LH. 2008. Regulation of hepatic lipogenesis by the transcription factor XBP1. Science 320(5882):1492-6.
Kaser A, Lee AH, Franke A, Glickman JN, Zeissig S, Tilg H, Nieuwenhuis EES, Higgins DE, Schreiber S, Glimcher LH, Blumberg RS. 2008. Transcription factor XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell 134:743-56.
Garrett W, Punit S, Gallini C, Michaud M, Zhang D, Sigrist K, Lord G, Glickman J, Glimcher LH. 2009. Colitis-associated colorectal cancer driven by T-bet deficiency in dendritic cells. Cancer Cell 16(3):208-19.
Hetz C, Thielen P, Matus S, Nassif M, Court F, María Cuervo AM, Martinez G, Kiffin R, Brown R, Glimcher LH. 2009. XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy. Genes and Development 23(19):2294-306. PMCID: 2758741.
Garrett WS, Gordon J, Glimcher LH. 2010. Homeostasis and inflammation in the Intestine. Cell 140(6):859-70.
Greenblatt MB, Shim JH, Zou W, Sitara D, Schweitzer M, Hu D, Lotinun S, Sano Y, Baron R, Park JM, Simon A, Xie M, Schneider MD, Zhai B, Gygi S, Davis R, Glimcher LH. 2010. A p 38 MAPK pathway essential for bone homeostasis.Journal of Clinical Investigation 120(7):2457-73.
Garrett WS, Gallini CA, Yatsunenko T, Michaud M, DuBois A, Delaney ML, Punit S, Karlsson M, Bry L, Glickman JN, Gordon JI, Onderdonk AB, Glimcher LH. 2010. Enterobacteriaceae act in concert with a gut microbiota to induce both spontaneous and maternally-transmitted colitis. Cell Host Microbe (in press).
National Academy of Sciences
National Academy of Sciences commonly refers to the academy in the United States of America.National Academy of Sciences may also refer to :* National Academy of Sciences of Argentina* Armenian National Academy of Sciences...
, is the incoming Dean of the Weill Cornell Medical College. She will succeed Antonio M. Gotto Jr.
Antonio Gotto
Dr. Antonio Gotto is Dean of Weill Medical College of Cornell University. He will be succeeded by Laurie H. Glimcher in January 2012. . Prior to his appointment in 1997, Gotto was chairman of the department of internal medicine at Baylor College of Medicine for twenty years, where he...
in January 2012.
Glimcher is Irene Heinz Given Professor of Immunology at the Harvard School of Public Health
Harvard School of Public Health
The Harvard School of Public Health is one of the professional graduate schools of Harvard University, located in the Longwood Area of the Boston, Massachusetts neighborhood of Mission Hill, which is next to Harvard Medical School. HSPH is considered a significant school focusing on health in the...
, and Professor of Medicine at Harvard Medical School
Harvard Medical School
Harvard Medical School is the graduate medical school of Harvard University. It is located in the Longwood Medical Area of the Mission Hill neighborhood of Boston, Massachusetts....
. and is a specialist in osteoporosis
Osteoporosis
Osteoporosis is a disease of bones that leads to an increased risk of fracture. In osteoporosis the bone mineral density is reduced, bone microarchitecture is deteriorating, and the amount and variety of proteins in bone is altered...
. She received her bachelors degree from Radcliffe College
Radcliffe College
Radcliffe College was a women's liberal arts college in Cambridge, Massachusetts, and was the coordinate college for Harvard University. It was also one of the Seven Sisters colleges. Radcliffe College conferred joint Harvard-Radcliffe diplomas beginning in 1963 and a formal merger agreement with...
in 1972 and her M.D. from Harvard in 1976.
Her research, according to her biography at Harvard, "uses biochemical and genetic approaches to elucidate the molecular pathways that regulate CD4
CD4
CD4 is a glycoprotein expressed on the surface of T helper cells, monocytes, macrophages, and dendritic cells. It was discovered in the late 1970s and was originally known as leu-3 and T4 before being named CD4 in 1984...
T helper cell development and activation. ... The Glimcher laboratory defined the genetic bases of both IL-4 and IFNg expression in T cells. They identified the proto-oncogene c-maf as the transcription factor
Transcription factor
In molecular biology and genetics, a transcription factor is a protein that binds to specific DNA sequences, thereby controlling the flow of genetic information from DNA to mRNA...
responsible for Th2-specific IL-4 expression [and]...discovered the first Th1-specific transcription factor, T-bet and demonstrated that this single factor is a master-regulator of IFNg gene expression and the Th1 phenotype."
She is reported by the Chronicle of Higher Education to have " extensive ties to two pharmaceutical companies, Merck
Merck
Merck may refer to:* Merck KGaA, , a German-based chemical and pharmaceutical company.** Merck Serono , the pharmaceutical division of Merck KGaA...
and Bristol-Myers Squibb
Bristol-Myers Squibb
Bristol-Myers Squibb , often referred to as BMS, is a pharmaceutical company, headquartered in New York City. The company was formed in 1989, following the merger of its predecessors Bristol-Myers and the Squibb Corporation...
.
According to the New York Times, since 1997 she has been on the Board of Bristol-Myers Squibb
Bristol-Myers Squibb
Bristol-Myers Squibb , often referred to as BMS, is a pharmaceutical company, headquartered in New York City. The company was formed in 1989, following the merger of its predecessors Bristol-Myers and the Squibb Corporation...
, and "received $244,5000 in compensation for 2010" and "1.4 million in deferred share units" Her research at Harvard has been paritally funded by a three-year contract with Merck, "the company that makes Fosamax". She is also on the Board of the Waters Corporation
Waters Corporation
Waters Corporation is a publicly traded laboratory analytical instrument and software company headquartered in Milford, Massachusetts. The company employs more than 5,000 people, with manufacturing facilities located in Milford, Taunton, Massachusetts; Wexford, Ireland; Manchester, England; and...
, af lab equipment manufacturer. In this article, she "defended her outside interests, saying they presented no conflict as long as they were transparent. She said she wanted to 'leverage the strengths of everyone,' whether scientists, pharmaceutical companies or biotechnology
Biotechnology
Biotechnology is a field of applied biology that involves the use of living organisms and bioprocesses in engineering, technology, medicine and other fields requiring bioproducts. Biotechnology also utilizes these products for manufacturing purpose...
companies. 'There should be no silos between all of these different strengths,' "
Memberships
- Fellow of the American Academy of Arts and SciencesAmerican Academy of Arts and SciencesThe American Academy of Arts and Sciences is an independent policy research center that conducts multidisciplinary studies of complex and emerging problems. The Academy’s elected members are leaders in the academic disciplines, the arts, business, and public affairs.James Bowdoin, John Adams, and...
, - Member of the Institute of MedicineInstitute of MedicineThe Institute of Medicine is a not-for-profit, non-governmental American organization founded in 1970, under the congressional charter of the National Academy of Sciences...
of the National Academy of Sciences - Member of the National Academy of Sciences.
- former President of American Association of Immunologists.
- Member of advisory boards at
- American Asthma FoundationAmerican Asthma FoundationThe American Asthma Foundation is a national advocacy group funding basic research focused on asthma. The mission of the American Asthma Foundation, a non-profit organization, is to improve treatment, prevent, and find a cure for asthma, a chronic lung condition affecting 25 million Americans.To...
, - Immune Diseases Institute,
- Health Care Ventures,
- Burroughs-Wellcome Fund
- Memorial Sloan Kettering Cancer Center
- American Asthma Foundation
- Board of Directors of
- Bristol-Myers Squibb Pharmaceutical Corporation
- the Waters Corporation
Awards
- Leukemia Society Stohlman Memorial Scholar Award,
- Arthritis Foundation's Lee S. Howley Award, the
- FASEB Excellence in Science Award,
- American Society of Clinical Investigation Investigator Award,
- Klemperer Award, the
- AAUW Senior Scholar
- Huang Meritorious Career Award,
- American College of Rheumatology Distinguished Investigator.
She was honored by a symposium at Harvard on April 15, 2011, titled " “A Commitment to Lineage: A Symposium in Celebration of Laurie Glimcher,.
Selected recent publications
jointly with other members of her laboratory:Ho I-C, Hodge MR, Rooney JW, Glimcher LH. 1996. The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4. Cell
Cell (journal)
Cell is a peer-reviewed scientific journal publishing research papers across a broad range of disciplines within the life sciences. Areas covered include molecular biology, cell biology, systems biology, stem cells, developmental biology, genetics and genomics, proteomics, cancer research,...
85:973-83.
Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman GC, Glimcher LH. 2000. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100:655-69.
Reimold AM, Iwakoshi NN, Manis J, Vallabhajosyula P, Szomolanyi-Tsuda E, Gravallese EM, Friend D, Grusby MJ, Alt F, Glimcher LH. 2001. Plasma cell differentiation requires transcription factor XBP-1. Nature
Nature (journal)
Nature, first published on 4 November 1869, is ranked the world's most cited interdisciplinary scientific journal by the Science Edition of the 2010 Journal Citation Reports...
412:300-7.
Szabo SJ, Sullivan BM, Stemmann C, Satoskar AR, Sleckman BP, Glimcher LH. 2002. Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science
Science (journal)
Science is the academic journal of the American Association for the Advancement of Science and is one of the world's top scientific journals....
295:338-42.
Finotto S, Neurath MF, Glickman JN, Qin S, Lehr HA, Green FH, Ackerman K, Haley K, Galle PR, Szabo SJ, Drazen JM, De Sanctis GT, Glimcher LH. 2002. Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science 295:336-8.
Maldonado RA, Irvine DJ, Schreiber R, Glimcher LH. 2004. A role for the immunological synapse in lineage commitment of CD4 lymphocytes. Nature 431:527-32.
Hwang ES, Szabo SJ, Schwartzberg PL, Glimcher LH. 2005. T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science 307:430-3.
Wang J, Fathman JW, Lugo-Villarino G, von Andrian U, Dorfman DM, Glimcher LH. 2006. Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells. Journal of Clinical Investigation
Journal of Clinical Investigation
The Journal of Clinical Investigation is a biomedical journal, with a 2010 impact factor of 14.152. The journal makes its research articles — including access to articles back to 1924 — freely available online....
16(2):414-21.
Jones DC, Wein MN, Oukka M, Hofstaetter JG, Glimcher MJ, Glimcher LH. 2006. Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3. Science 312(5777):1223-7.
Garrett W, Lord GM, Punit S, Lugo G, Mazmanian S, Ito S, Glickman J, Glimcher LH. 2007. Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell 131:33-45.
Lee Ah, Scapa EF, Cohen DE, Glimcher LH. 2008. Regulation of hepatic lipogenesis by the transcription factor XBP1. Science 320(5882):1492-6.
Kaser A, Lee AH, Franke A, Glickman JN, Zeissig S, Tilg H, Nieuwenhuis EES, Higgins DE, Schreiber S, Glimcher LH, Blumberg RS. 2008. Transcription factor XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell 134:743-56.
Garrett W, Punit S, Gallini C, Michaud M, Zhang D, Sigrist K, Lord G, Glickman J, Glimcher LH. 2009. Colitis-associated colorectal cancer driven by T-bet deficiency in dendritic cells. Cancer Cell 16(3):208-19.
Hetz C, Thielen P, Matus S, Nassif M, Court F, María Cuervo AM, Martinez G, Kiffin R, Brown R, Glimcher LH. 2009. XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy. Genes and Development 23(19):2294-306. PMCID: 2758741.
Garrett WS, Gordon J, Glimcher LH. 2010. Homeostasis and inflammation in the Intestine. Cell 140(6):859-70.
Greenblatt MB, Shim JH, Zou W, Sitara D, Schweitzer M, Hu D, Lotinun S, Sano Y, Baron R, Park JM, Simon A, Xie M, Schneider MD, Zhai B, Gygi S, Davis R, Glimcher LH. 2010. A p 38 MAPK pathway essential for bone homeostasis.Journal of Clinical Investigation 120(7):2457-73.
Garrett WS, Gallini CA, Yatsunenko T, Michaud M, DuBois A, Delaney ML, Punit S, Karlsson M, Bry L, Glickman JN, Gordon JI, Onderdonk AB, Glimcher LH. 2010. Enterobacteriaceae act in concert with a gut microbiota to induce both spontaneous and maternally-transmitted colitis. Cell Host Microbe (in press).