Leucine-2-alanine enkephalin
Encyclopedia
DADLE is a synthetic
opioid peptide
with analgesic
properties. Although it is often considered a selective delta opioid receptor
agonist, it also binds to the μ1 subtype of mu opioid receptor
s.
Treatment with DADLE results in transient depression
of mean arterial blood pressure
and heart rate
.
Its peptide sequence is Tyr-D-Ala-Gly-Phe-D-Leu.
Chemical synthesis
In chemistry, chemical synthesis is purposeful execution of chemical reactions to get a product, or several products. This happens by physical and chemical manipulations usually involving one or more reactions...
opioid peptide
Opioid peptide
Opioid peptides are short sequences of amino acids that bind to opioid receptors in the brain; opiates and opioids mimic the effect of these peptides. Opioid peptides may be produced by the body itself, for example endorphins. The effects of these peptides vary, but they all resemble opiates...
with analgesic
Analgesic
An analgesic is any member of the group of drugs used to relieve pain . The word analgesic derives from Greek an- and algos ....
properties. Although it is often considered a selective delta opioid receptor
Delta Opioid receptor
The δ-opioid receptors, also known as delta opioid receptor or simply delta receptor, abbreviated DOR, is an opioid receptor that has enkephalins as its endogenous ligands.-Function:...
agonist, it also binds to the μ1 subtype of mu opioid receptor
Mu Opioid receptor
The μ-opioid receptors are a class of opioid receptors with high affinity for enkephalins and beta-endorphin but low affinity for dynorphins. They are also referred to as μ opioid peptide receptors. The prototypical μ receptor agonist is the opium alkaloid morphine; μ refers to morphine...
s.
Treatment with DADLE results in transient depression
Depression (physiology)
Depression in physiology and medicine refers to a lowering, in particular a reduction in a particular biological variable or the function of an organ...
of mean arterial blood pressure
Blood pressure
Blood pressure is the pressure exerted by circulating blood upon the walls of blood vessels, and is one of the principal vital signs. When used without further specification, "blood pressure" usually refers to the arterial pressure of the systemic circulation. During each heartbeat, BP varies...
and heart rate
Heart rate
Heart rate is the number of heartbeats per unit of time, typically expressed as beats per minute . Heart rate can vary as the body's need to absorb oxygen and excrete carbon dioxide changes, such as during exercise or sleep....
.
Its peptide sequence is Tyr-D-Ala-Gly-Phe-D-Leu.