Levocabastine
Encyclopedia
Levocabastine is a selective second-generation H1-receptor antagonist which was discovered at Janssen Pharmaceutica
in 1979. It is used for allergic conjunctivitis
.
As well as acting as an antihistamine, levocabastine has also subsequently been found to act as a potent and selective antagonist for the neurotensin
receptor NTS2
, and was the first drug used to characterise the different neurotensin subtypes. This has made it a useful tool for the study of this receptor.
Janssen Pharmaceutica
Janssen Pharmaceutica is pharmaceutical company, established in Belgium in 1953 by Paul Janssen. Its headquarters are located in Beerse, in the Campine region of the province of Antwerp, Belgium. It was created not as a subsidiary of a chemical factory but solely with the aim of conducting...
in 1979. It is used for allergic conjunctivitis
Conjunctivitis
Conjunctivitis refers to inflammation of the conjunctiva...
.
As well as acting as an antihistamine, levocabastine has also subsequently been found to act as a potent and selective antagonist for the neurotensin
Neurotensin
Neurotensin is a 13 amino acid neuropeptide that is implicated in the regulation of luteinizing hormone and prolactin release and has significant interaction with the dopaminergic system...
receptor NTS2
Neurotensin receptor 2
Neurotensin receptor type 2 is a protein that in humans is encoded by the NTSR2 gene.-Further reading:...
, and was the first drug used to characterise the different neurotensin subtypes. This has made it a useful tool for the study of this receptor.