Janssen Pharmaceutica
Encyclopedia
Janssen Pharmaceutica is pharmaceutical company
, established in Belgium
in 1953 by Paul Janssen
. Its headquarters are located in Beerse
, in the Campine
region of the province of Antwerp
, Belgium. It was created not as a subsidiary of a chemical factory but solely with the aim of conducting pharmacological
research. The company's stated aim is the continuous development of better drug
s to improve the quality of life. In 1961 Janssen Pharmaceutica was purchased by Johnson & Johnson
corporation and is now part of the company's worldwide research and development centre, the Johnson & Johnson Pharmaceutical Research and Development
(J&J PRD) which conducts research and development activities related to a wide range of human medical disorders, including mental illness
, neurological disorders
, anaesthesia
and analgesia
, gastrointestinal
disorders, fungal infection, allergies
and cancer
. Janssen and Ortho-McNeil Pharmaceutical
have been placed in the Ortho-McNeil-Janssen
group within Johnson & Johnson. Its Chairman and Managing Director is the baron Ajit Shetty
.
, the father of Paul Janssen, acquired the right to distribute the pharmaceutical products of Richter
, a Hungarian
pharmaceutical company, for Belgium, the Netherlands
and Belgian Congo
. On 23 October 1934, he founded the N.V. Produkten Richter in Turnhout. In 1937 Constant Janssen acquired an old factory building in the Statiestraat 78 in Turnhout for his growing company, which he expanded during World War II
into a four-storey building. Still a student, Paul Janssen assisted in the development of Perdolan. After the war, the name for the company products was changed in Eupharma, although the company name Richter would remain until 1956.
Paul Janssen founded his own research laboratory in 1953 on the third floor of the building in the Statiestraat, still within the Richter-Eurpharma company of his father. In 1955, he and his team developed their first drug: Neomeritine (ambucetamide
), an antispasmodic found to be particularly effective for the relief of menstrual pain. On 5 April 1956, the name of the company was changed in NV Laboratoria Pharmaceutica C. Janssen (named after Constant Janssen). On 27 April 1957, the company opened a new research facility in Beerse, but the move to Beerse would not be completed until 1971-1972. On 2 May 1958, the research department in Beerse became a separate legal entity, the N.V. Research Laboratorium C. Janssen.
On 24 October 1961, the company was acquired by the American corporation Johnson & Johnson
. The negotiations with Johnson & Johnson were led by Frans Van den Bergh
, head of the Board of Directors. On 10 February 1964, the name was changed to Janssen Pharmaceutica N.V. and the seat of the company in Turnhout was also transferred to Beerse. The company was led by Paul Janssen, Bob Stouthuysen
and Frans Van Den Bergh. When, in 1971-1972 the pharmaceutical production also moved to Beerse, the move from Turnhout was completed. Between 1990 and 2004, Janssen Pharmaceutica expanded worldwide, and the company grew in size to about 28000 employees worldwide. 4600 of these were based in Belgium.
From the beginning, Janssen Pharmaceutica emphasized as its core activity research for the development of new drugs. The research department which was established in Beerse in 1957, developed into a large research campus. In 1987, the Janssen Research Foundation (JRF) was founded which performs research into new drugs at Beerse and in other laboratories around the globe. Janssen Pharmaceutica became the Flemish company with the largest budget for research and development. Beside the headquarters in Beerse with its research departments, pharmaceutical production and the administrative departments, Janssen Pharmaceutica in Belgium still has offices in Berchem
(Janssen-Cilag
), a chemical factory in Geel
, and Janssen Biotech in Olen.
The Chemical Production plant in Geel, makes the active ingredient
s for the company’s medicines. In 1975, the first plant of a new chemical factory Plant I was established in Geel, Plant II was opened in 1977, Plant III in 1984, and Plant IV in 1995. In 1999 the remaining chemical production in Beerse was transferred to Geel. About 80% of its active components are manufactured here. The site in Geel also manufactures about two-thirds of the worldwide chemical production of the pharmaceutical sector of Johnson & Johnson
. In 1995, the Center for Molecular Design (CMD) was founded by Paul Janssen and Paul Lewi
.
In 1999, clinical research and non-clinical development become a global organization within Johnson & Johnson. In 2001, part of the research activities was transferred to the United States
with the reorganization of research activities in the Johnson & Johnson Pharmaceutical Research Development (JJPRD) organization. The research activities of the Janssen Research Foundation (JRF) and the R.W. Johnson Pharmaceutical Research Institute (PRI) (United States
) were merged into the new global research organization. A new building for pharmaceutical development was completed in Beerse in 2001. In 2002, a new logistics and informatics centre was opened at a new site, Beerse 2. In 2003 two new research buildings were constructed, the Discovery Research Center (DRC), and the Drug Safety Evaluation Center (DSEC). On 27 October 2004, the Paul Janssen Research Center, for discovery research, was inaugurated.
The success of Janssen Pharmaceutica is commonly attributed to the vision of its founder, who himself was a brilliant scientist, but was also surrounded by talented and motivated employees, both scientifically and commercially. Paul Janssen created an environment which stimulated the creativity of his research workers.
(Xi'an
). Already in 1983, Janssen had signed a cooperation contract to modernise products in an existing, but old, chemical factory in Hanzhong
(in the province Shaanxi
) and to produce the active compound of some Janssen products, such as mebendazole
. Paul Appermont
and Joos Horsten
were responsible for the project.
In 1976 Paul Janssen had met the Lebanese-American doctor George Shafik Hatem (1912–1988) who was known in China under the name Ma Haide. Paul Janssen met with Ma Haide for three days in 1976, and decided to start a business in China right after the Cultural Revolution
(1967–1976) and the opening to the west by Deng Xiaoping
in 1978. The first factory was set up by Joos Horsten
in Hanzhong, after which the second and larger factory followed in Xi'an.
Janssen Pharmaceutica has developed and brought to the market about 70 new active substances (NCE
), of which the most well-known are (name may differ):
Five drugs of Janssen Pharmaceutica have been included on the WHO Model List of Essential Medicines:
R207910
is an experimental diarylquinoline anti-tuberculosis drug, discovered by Koen Andries
and his team, which promises a shorter and simpler treatment
for Tuberculosis
(TB).
Pharmaceutical company
The pharmaceutical industry develops, produces, and markets drugs licensed for use as medications. Pharmaceutical companies are allowed to deal in generic and/or brand medications and medical devices...
, established in Belgium
Belgium
Belgium , officially the Kingdom of Belgium, is a federal state in Western Europe. It is a founding member of the European Union and hosts the EU's headquarters, and those of several other major international organisations such as NATO.Belgium is also a member of, or affiliated to, many...
in 1953 by Paul Janssen
Paul Janssen
Paul Adriaan Jan, Baron Janssen was the founder of Janssen Pharmaceutica, a pharmaceutical company with over 20,000 employees. In 2005 he finished as runner up, after Father Damien, in the poll for The Greatest Belgian organized by the regional Flemish television...
. Its headquarters are located in Beerse
Beerse
Beerse is a municipality located in the Belgian province of Antwerp. The municipality comprises the towns of Beerse proper and Vlimmeren. On 1 January 2006 Beerse had a total population of 16,482. By the end of 2007, this number had risen to 16,757. The total area is 37.48 km² which gives a...
, in the Campine
Campine
The Campine is a natural region situated chiefly in north-eastern Belgium and parts of the south-western Netherlands which once consisted mainly of extensive moors, tracts of sandy heath, and wetlands...
region of the province of Antwerp
Antwerp (province)
Antwerp is the northernmost province both of the Flemish Region, also called Flanders, and of Belgium. It borders on the Netherlands and the Belgian provinces of Limburg, Flemish Brabant and East Flanders. Its capital is Antwerp which comprises the Port of Antwerp...
, Belgium. It was created not as a subsidiary of a chemical factory but solely with the aim of conducting pharmacological
Pharmacology
Pharmacology is the branch of medicine and biology concerned with the study of drug action. More specifically, it is the study of the interactions that occur between a living organism and chemicals that affect normal or abnormal biochemical function...
research. The company's stated aim is the continuous development of better drug
Drug
A drug, broadly speaking, is any substance that, when absorbed into the body of a living organism, alters normal bodily function. There is no single, precise definition, as there are different meanings in drug control law, government regulations, medicine, and colloquial usage.In pharmacology, a...
s to improve the quality of life. In 1961 Janssen Pharmaceutica was purchased by Johnson & Johnson
Johnson & Johnson
Johnson & Johnson is an American multinational pharmaceutical, medical devices and consumer packaged goods manufacturer founded in 1886. Its common stock is a component of the Dow Jones Industrial Average and the company is listed among the Fortune 500....
corporation and is now part of the company's worldwide research and development centre, the Johnson & Johnson Pharmaceutical Research and Development
Johnson & Johnson Pharmaceutical Research and Development
Johnson & Johnson Pharmaceutical Research and Development is a subsidiary of Johnson & Johnson that is responsible for discovering and developing pharmaceutical drugs...
(J&J PRD) which conducts research and development activities related to a wide range of human medical disorders, including mental illness
Mental illness
A mental disorder or mental illness is a psychological or behavioral pattern generally associated with subjective distress or disability that occurs in an individual, and which is not a part of normal development or culture. Such a disorder may consist of a combination of affective, behavioural,...
, neurological disorders
Neurology
Neurology is a medical specialty dealing with disorders of the nervous system. Specifically, it deals with the diagnosis and treatment of all categories of disease involving the central, peripheral, and autonomic nervous systems, including their coverings, blood vessels, and all effector tissue,...
, anaesthesia
Anesthesia
Anesthesia, or anaesthesia , traditionally meant the condition of having sensation blocked or temporarily taken away...
and analgesia
Analgesic
An analgesic is any member of the group of drugs used to relieve pain . The word analgesic derives from Greek an- and algos ....
, gastrointestinal
Gastrointestinal tract
The human gastrointestinal tract refers to the stomach and intestine, and sometimes to all the structures from the mouth to the anus. ....
disorders, fungal infection, allergies
Allergy
An Allergy is a hypersensitivity disorder of the immune system. Allergic reactions occur when a person's immune system reacts to normally harmless substances in the environment. A substance that causes a reaction is called an allergen. These reactions are acquired, predictable, and rapid...
and cancer
Cancer
Cancer , known medically as a malignant neoplasm, is a large group of different diseases, all involving unregulated cell growth. In cancer, cells divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. The cancer may also spread to more distant parts of the...
. Janssen and Ortho-McNeil Pharmaceutical
Ortho-McNeil Pharmaceutical
The company was formed from the merger of Ortho Pharmaceutical and McNeil Pharmaceutical in 1993. Both of these pharmaceutical companies are pioneers and leaders in areas such as pain management, acid reflux disease, and infectious diseases...
have been placed in the Ortho-McNeil-Janssen
Ortho-McNeil-Janssen
Ortho-McNeil-Janssen Pharmaceuticals, Inc is a healthcare company of Johnson & Johnson composed of two divisions:* Ortho-McNeil, based in Raritan, NJ ; the division is focused on primary care....
group within Johnson & Johnson. Its Chairman and Managing Director is the baron Ajit Shetty
Ajit Shetty
Ajit, Baron Shetty is an Indian-Belgian businessman, who was born in Nellore, India on 20 May 1946. He is Chairman of the Board of Directors and Managing Director of Janssen Pharmaceutica, a pharmaceutical company and subsidiary of Johnson & Johnson, with its headquarters in Beerse, Belgium...
.
History
The early roots of what would become Janssen Pharmaceutica date back to 1933. In 1933 Constant JanssenConstant Janssen
Dr. Jan Constant Janssen , was a Belgian physician and businessman. He was the third child of Adriaan Victor Janssen and Anna Catharina Eelen . He went to highschool in Hoogstraten and studied medicine at the Catholic University of Leuven and the University of Ghent...
, the father of Paul Janssen, acquired the right to distribute the pharmaceutical products of Richter
Gedeon Richter Ltd.
Gedeon Richter Plc. , the largest pharmaceutical factory in Hungary, was established by Mr. Gedeon Richter, a pharmacist in 1901. Mr. Richter is not only the founder of the company, but the establishment of his firm also marked the beginning of the development of the Hungarian pharmaceutical industry...
, a Hungarian
Hungary
Hungary , officially the Republic of Hungary , is a landlocked country in Central Europe. It is situated in the Carpathian Basin and is bordered by Slovakia to the north, Ukraine and Romania to the east, Serbia and Croatia to the south, Slovenia to the southwest and Austria to the west. The...
pharmaceutical company, for Belgium, the Netherlands
Netherlands
The Netherlands is a constituent country of the Kingdom of the Netherlands, located mainly in North-West Europe and with several islands in the Caribbean. Mainland Netherlands borders the North Sea to the north and west, Belgium to the south, and Germany to the east, and shares maritime borders...
and Belgian Congo
Belgian Congo
The Belgian Congo was the formal title of present-day Democratic Republic of the Congo between King Leopold II's formal relinquishment of his personal control over the state to Belgium on 15 November 1908, and Congolese independence on 30 June 1960.-Congo Free State, 1884–1908:Until the latter...
. On 23 October 1934, he founded the N.V. Produkten Richter in Turnhout. In 1937 Constant Janssen acquired an old factory building in the Statiestraat 78 in Turnhout for his growing company, which he expanded during World War II
World War II
World War II, or the Second World War , was a global conflict lasting from 1939 to 1945, involving most of the world's nations—including all of the great powers—eventually forming two opposing military alliances: the Allies and the Axis...
into a four-storey building. Still a student, Paul Janssen assisted in the development of Perdolan. After the war, the name for the company products was changed in Eupharma, although the company name Richter would remain until 1956.
Paul Janssen founded his own research laboratory in 1953 on the third floor of the building in the Statiestraat, still within the Richter-Eurpharma company of his father. In 1955, he and his team developed their first drug: Neomeritine (ambucetamide
Ambucetamide
Ambucetamide is an antispasmodic found to be particularly effective for the relief of menstrual pain. It was discovered in 1953 by Paul Janssen.-References:...
), an antispasmodic found to be particularly effective for the relief of menstrual pain. On 5 April 1956, the name of the company was changed in NV Laboratoria Pharmaceutica C. Janssen (named after Constant Janssen). On 27 April 1957, the company opened a new research facility in Beerse, but the move to Beerse would not be completed until 1971-1972. On 2 May 1958, the research department in Beerse became a separate legal entity, the N.V. Research Laboratorium C. Janssen.
On 24 October 1961, the company was acquired by the American corporation Johnson & Johnson
Johnson & Johnson
Johnson & Johnson is an American multinational pharmaceutical, medical devices and consumer packaged goods manufacturer founded in 1886. Its common stock is a component of the Dow Jones Industrial Average and the company is listed among the Fortune 500....
. The negotiations with Johnson & Johnson were led by Frans Van den Bergh
Frans Van den Bergh
Baron Frans Van den Bergh was a Belgian business man, who founded the cigar factory Alto in Turnhout, Belgium and who would become one of the leading managers of Janssen Pharmaceutica. In addition to his success with Alto, he was by the marriage of his daughter Lea related to Margriet...
, head of the Board of Directors. On 10 February 1964, the name was changed to Janssen Pharmaceutica N.V. and the seat of the company in Turnhout was also transferred to Beerse. The company was led by Paul Janssen, Bob Stouthuysen
Bob Stouthuysen
Baron Robert "Bob" Stouthuysen is a Belgian businessman. He is honorary president of the Vlaams Economisch Verbond and of Janssen Pharmaceutica. He lives in Kasterlee in the Campine region of Flanders.-Education:...
and Frans Van Den Bergh. When, in 1971-1972 the pharmaceutical production also moved to Beerse, the move from Turnhout was completed. Between 1990 and 2004, Janssen Pharmaceutica expanded worldwide, and the company grew in size to about 28000 employees worldwide. 4600 of these were based in Belgium.
From the beginning, Janssen Pharmaceutica emphasized as its core activity research for the development of new drugs. The research department which was established in Beerse in 1957, developed into a large research campus. In 1987, the Janssen Research Foundation (JRF) was founded which performs research into new drugs at Beerse and in other laboratories around the globe. Janssen Pharmaceutica became the Flemish company with the largest budget for research and development. Beside the headquarters in Beerse with its research departments, pharmaceutical production and the administrative departments, Janssen Pharmaceutica in Belgium still has offices in Berchem
Berchem
The 'Ring', Antwerp's circular motorway which follows the track of the former city defense walls, cuts Berchem in two parts, separating the urban inner city area of Oud-Berchem from the more residential and suburban areas Groenenhoek en Nieuw Kwartier .-Demography:Berchem's total surface is over ,...
(Janssen-Cilag
Janssen-Cilag
Janssen-Cilag is a subsidiary of the Johnson & Johnson pharmaceutical company. The company was founded in the early 1950s by a merger between Janssen Pharmaceutica and Cilag....
), a chemical factory in Geel
Geel
Geel is a city located in the Belgian province of Antwerp which acquired the status of a city in the 1980s.It comprises Central-Geel which is constituted of 4 old parishes a/o towns : Sint-Amand, Sint-Dimpna, Holven and Elsum...
, and Janssen Biotech in Olen.
The Chemical Production plant in Geel, makes the active ingredient
Active ingredient
An active ingredient is the substance of a pharmaceutical drug or a pharmaceutical ingredient and bulk active in medicine; in pesticide formulations active substance may be used. Some medications and pesticide products may contain more than one active ingredient...
s for the company’s medicines. In 1975, the first plant of a new chemical factory Plant I was established in Geel, Plant II was opened in 1977, Plant III in 1984, and Plant IV in 1995. In 1999 the remaining chemical production in Beerse was transferred to Geel. About 80% of its active components are manufactured here. The site in Geel also manufactures about two-thirds of the worldwide chemical production of the pharmaceutical sector of Johnson & Johnson
Johnson & Johnson
Johnson & Johnson is an American multinational pharmaceutical, medical devices and consumer packaged goods manufacturer founded in 1886. Its common stock is a component of the Dow Jones Industrial Average and the company is listed among the Fortune 500....
. In 1995, the Center for Molecular Design (CMD) was founded by Paul Janssen and Paul Lewi
Paul Lewi
Paul J. Lewi is a Belgian scientist, who elaborated Spectral Map Analysis in 1975 and was one of the cofounders of chemometrics in 1983. Paul Lewi is married with Philomena Van Bylen, and together they have 5 children.- Biography :...
.
In 1999, clinical research and non-clinical development become a global organization within Johnson & Johnson. In 2001, part of the research activities was transferred to the United States
United States
The United States of America is a federal constitutional republic comprising fifty states and a federal district...
with the reorganization of research activities in the Johnson & Johnson Pharmaceutical Research Development (JJPRD) organization. The research activities of the Janssen Research Foundation (JRF) and the R.W. Johnson Pharmaceutical Research Institute (PRI) (United States
United States
The United States of America is a federal constitutional republic comprising fifty states and a federal district...
) were merged into the new global research organization. A new building for pharmaceutical development was completed in Beerse in 2001. In 2002, a new logistics and informatics centre was opened at a new site, Beerse 2. In 2003 two new research buildings were constructed, the Discovery Research Center (DRC), and the Drug Safety Evaluation Center (DSEC). On 27 October 2004, the Paul Janssen Research Center, for discovery research, was inaugurated.
The success of Janssen Pharmaceutica is commonly attributed to the vision of its founder, who himself was a brilliant scientist, but was also surrounded by talented and motivated employees, both scientifically and commercially. Paul Janssen created an environment which stimulated the creativity of his research workers.
Janssen Pharmaceutica in China
In 1985, Janssen Pharmaceutica was the first Western pharmaceutical company to set up a pharmaceutical factory in the People's Republic of ChinaPeople's Republic of China
China , officially the People's Republic of China , is the most populous country in the world, with over 1.3 billion citizens. Located in East Asia, the country covers approximately 9.6 million square kilometres...
(Xi'an
Xi'an
Xi'an is the capital of the Shaanxi province, and a sub-provincial city in the People's Republic of China. One of the oldest cities in China, with more than 3,100 years of history, the city was known as Chang'an before the Ming Dynasty...
). Already in 1983, Janssen had signed a cooperation contract to modernise products in an existing, but old, chemical factory in Hanzhong
Hanzhong
Hanzhong is a municipality in southwest Shaanxi Province, China, occupying a historically significant valley in the mountains between the Xi'an area, home to many Chinese capitals, and the fertile but isolated Sichuan Basin...
(in the province Shaanxi
Shaanxi
' is a province in the central part of Mainland China, and it includes portions of the Loess Plateau on the middle reaches of the Yellow River in addition to the Qinling Mountains across the southern part of this province...
) and to produce the active compound of some Janssen products, such as mebendazole
Mebendazole
Mebendazole or MBZ is a benzimidazole drug developed by Janssen Pharmaceutica and marketed as Vermox, Ovex, Antiox, and Pripsen...
. Paul Appermont
Paul Appermont
Paul Appermont is a Belgian businessman. Together with Joos Horsten, he laid the foundation of Xi'an Janssen Pharmaceutical...
and Joos Horsten
Joos Horsten
Joos Horsten was a Belgian businessman. He founded Xian Janssen Pharmaceutical, the Sino-Belgian joint venture of Janssen Pharmaceutica, a Flemish pharmaceutical company in Belgium.-Career:...
were responsible for the project.
In 1976 Paul Janssen had met the Lebanese-American doctor George Shafik Hatem (1912–1988) who was known in China under the name Ma Haide. Paul Janssen met with Ma Haide for three days in 1976, and decided to start a business in China right after the Cultural Revolution
Cultural Revolution
The Great Proletarian Cultural Revolution, commonly known as the Cultural Revolution , was a socio-political movement that took place in the People's Republic of China from 1966 through 1976...
(1967–1976) and the opening to the west by Deng Xiaoping
Deng Xiaoping
Deng Xiaoping was a Chinese politician, statesman, and diplomat. As leader of the Communist Party of China, Deng was a reformer who led China towards a market economy...
in 1978. The first factory was set up by Joos Horsten
Joos Horsten
Joos Horsten was a Belgian businessman. He founded Xian Janssen Pharmaceutical, the Sino-Belgian joint venture of Janssen Pharmaceutica, a Flemish pharmaceutical company in Belgium.-Career:...
in Hanzhong, after which the second and larger factory followed in Xi'an.
Some drugs developed by Janssen Pharmaceutica
| R-code | Name | Brandname | Synthetized | Marketed |
| R5 | ambucetamide Ambucetamide Ambucetamide is an antispasmodic found to be particularly effective for the relief of menstrual pain. It was discovered in 1953 by Paul Janssen.-References:... | Neomeritine | 1953 | 1955 |
| R79 | isopropamide iodide | Priamide-Janssen | 1954 | 1955 |
| R253 | diisopromine Diisopromine Diisopromine or disoprominum, usually as the hydrochloride salt, is a synthetic spasmolytic which neutralizes spastic conditions of the biliary tract and of the sphincter of Oddi. It was discovered at Janssen Pharmaceutica in 1955.-References:... | Bilagol | 1955 | 1956 |
| R516 | cinnarizine Cinnarizine Cinnarizine is an antihistamine which is mainly used for the control of nausea and vomiting due to motion sickness. Cinnarizine was first synthesized by Janssen Pharmaceutica in 1955... | Stugeron | 1955 | 1958 |
| R875 | dextromoramide Dextromoramide Dextromoramide is a powerful opioid analgesic approximately three times more potent than morphine but shorter acting. It is subject to drug prohibition regimes, both internationally through UN treaties, and by the criminal law of individual states... | Palfium | 1955 | 1957 |
| R1132 | diphenoxylate Diphenoxylate Diphenoxylate is an opioid agonist used for the treatment of diarrhea that acts by slowing intestinal contractions and peristalsis allowing the body to consolidate intestinal contents and prolong transit time, thus allowing the intestines to draw moisture out of them at a normal or higher rate and... | Reasec | 1956 | 1960 |
| R1625 | haloperidol Haloperidol Haloperidol is a typical antipsychotic. It is in the butyrophenone class of antipsychotic medications and has pharmacological effects similar to the phenothiazines.... | Haldol | 1958 | 1959 |
| R2498 | trifluperidol Trifluperidol Trifluperidol is a typical antipsychotic of the butyrophenone chemical class. It has general properties similar to those of haloperidol, but is considerably more potent by weight, and causes relatively more severe side effects, especially tardive dyskinesia and other extrapyramidal effects. It is... | Triperidol | 1959 | 1961 |
| R3345 | pipamperone Pipamperone Pipamperone is an antipsychotic drug used in the treatment of schizophrenia. Pipamperone is known to the general public under the marketed brand name Dipiperon. It was discovered at Janssen Pharmaceutica in 1960.... | Dipiperon | 1960 | 1961 |
| R3365 | piritramide Piritramide Piritramide is a synthetic opioid analgesic with a potency 0.65 to 0.75 times that of morphine. A common starting dose is 15 mg IV, equivalent to 10 mg of morphine hydrochloride. Piritramide is commonly used for the treatment of postoperative pain... | Dipidolor | 1960 | 1967 |
| R4263 | fentanyl | Fentanyl | 1960 | 1963 |
| R4584 | benperidol Benperidol Benperidol is a drug which is a highly potent butyrophenone derivative. It is in fact the most potent neuroleptic on the European market, with chlorpromazine equivalency as high as 75 to 100 .... | Frenactyl | 1961 | 1965 |
| R4749 | droperidol Droperidol Droperidol is an antidopaminergic drug used as an antiemetic and antipsychotic... | Dehydrobenzperidol | 1961 | 1963 |
| R4845 | bezitramide Bezitramide Bezitramide is a narcotic analgesic. Bezitramide itself is a prodrug which is readily hydrolyzed in the gastrointestinal tract to its main metabolite, despropionyl-bezitramide. Bezitramide was discovered at Janssen Pharmaceutica in 1961... | Burgodin | 1961 | 1971 |
| R6218 | fluspirilene Fluspirilene Fluspirilene is a diphenylbutylpiperidine antipsychotic drug, used for the treatment of schizophrenia. It is administered intramuscularly. It was discovered at Janssen Pharmaceutica in 1963.-Chemistry:... | Imap | 1963 | 1971 |
| R6238 | pimozide Pimozide Pimozide is an antipsychotic drug of the diphenylbutylpiperidine class. It was discovered at Janssen Pharmaceutica in 1963. It has a high potency compared to chlorpromazine . On a weight basis it is even more potent than haloperidol. It also has special neurologic indications for Tourette syndrome... | Orap | 1963 | 1970 |
| R7904 | lidoflazine Lidoflazine Lidoflazine is a piperazine calcium channel blocker. It is a coronary vasodilator with some antiarrhythmic action. Lidoflazine was discovered at Janssen Pharmaceutica in 1964.-Solubility at room temperature:Extracted from -References:... | Clinium | 1964 | 1969 |
| R11333 | bromperidol Bromperidol Bromperidol is a drug which is a butyrophenone derivative. It is a potent and long-acting neuroleptic, used as an antipsychotic in the treatment of schizophrenia. It was discovered at Janssen Pharmaceutica in 1966.- References :... | Impromen | 1966 | 1981 |
| R12564 | levamisole Levamisole Levamisole is an anthelminthic and immunomodulator belonging to a class of synthetic imidazothiazole derivatives. It was discovered at Janssen Pharmaceutica in 1966... | Ergamisol | 1966 | 1969 |
| R13672 | haloperidol decanoate Haloperidol Haloperidol is a typical antipsychotic. It is in the butyrophenone class of antipsychotic medications and has pharmacological effects similar to the phenothiazines.... | Haldol decanoas | 1967 | 1981 |
| R14889 | miconazole nitrate | Daktarin | 1967 | 1971 |
| R14950 | flunarizine Flunarizine Flunarizine is a drug classified as a calcium channel blocker. Flunarizine is a non-selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and... | Sibelium | 1967 | 1977 |
| R15889 | lorcainide Lorcainide Lorcainide is a class 1c antiarrhythmic agent. It was discovered at Janssen Pharmaceutica in 1968.-References:* Kesteloot H, Stroobandt R., Clinical experience with lorcainide , a new anti-arrhythmic drug, Arch Int Pharmacodyn Ther... | Remivox | 1968 | 1983 |
| R16341 | penfluridol Penfluridol Penfluridol is a highly potent, first generation diphenylbutylpiperidine antipsychotic. It was discovered at Janssen Pharmaceutica in 1968. Related to other diphenylbutylpiperidine antipsychotics, pimozide and fluspirilene, penfluridol has an extremely long elimination half-life and its effects... | Semap | 1968 | 1973 |
| R16470 | dexetimide Dexetimide Dexetimide is a piperidine anticholinergic. It is a muscarinic antagonist that has been used to treat neuroleptic-induced Parkinsonism. Dexetimide was discovered at Janssen Pharmaceutica in 1968.... | Tremblex | 1968 | 1972 |
| R16659 | etomidate Etomidate Etomidate is a short acting intravenous anaesthetic agent used for the induction of general anaesthesia and for sedation for short procedures such as reduction of dislocated joints, tracheal intubation and cardioversion... | Hypnomidate | 1964 | 1977 |
| R17635 | mebendazole Mebendazole Mebendazole or MBZ is a benzimidazole drug developed by Janssen Pharmaceutica and marketed as Vermox, Ovex, Antiox, and Pripsen... | Vermox | 1968 | 1972 |
| R18553 | loperamide Loperamide Loperamide , a synthetic piperidine derivative, is an opioid drug used against diarrhea resulting from gastroenteritis or inflammatory bowel disease. In most countries it is available generically and under brand names such as Lopex, Imodium, Dimor, Fortasec, and Pepto Diarrhea Control... | Imodium | 1969 | 1973 |
| R33800 | sufentanil Sufentanil Sufentanil is a powerful synthetic opioid analgesic drug, approximately 5 to 10 times more potent than its analog, fentanyl. Sufentanil is marketed for use by specialist centres under different trade names, such as Sufenta and Sufentil... | Sufenta | 1974 | 1979 |
| R33812 | domperidone Domperidone Domperidone is an antidopaminergic drug, developed by Janssen Pharmaceutica, and used orally, rectally or intravenously, generally to suppress nausea and vomiting, or as a prokinetic agent... | Motilium | 1974 | 1978 |
| R35443 | oxatomide Oxatomide Oxatomide is a first-generation antihistamine of the phenylpiperazine class. It was discovered at Janssen Pharmaceutica in 1975. Oxatomide lacks any anticholinergic effects. In addition to its H1 receptor antagonism, it also possesses antiserotonergic actions.... | Tinset | 1975 | 1981 |
| R39209 | alfentanil Alfentanil Alfentanil is a potent but short-acting synthetic opioid analgesic drug, used for anaesthesia in surgery. It is an analogue of fentanyl with around 1/4 the potency of fentanyl and around 1/3 of the duration of action, but with an onset of effects 4x faster than fentanyl... | Rapifen | 1976 | 1983 |
| R33799 | carfentanil Carfentanil Carfentanil or carfentanyl is an analogue of the popular synthetic opioid analgesic fentanyl, and is one of the most potent opioids known . Carfentanil was first synthesized in 1974 by a team of chemists at Janssen Pharmaceutica which included Paul Janssen... | Wildnil | 1976 | 1980? |
| R41400 | ketoconazole Ketoconazole Ketoconazole is a synthetic antifungal drug used to prevent and treat fungal skin infections, especially in immunocompromised patients such as those with AIDS or those on chemotherapy. Ketoconazole is sold commercially as an anti-dandruff shampoo, topical cream, and oral tablet.Ketoconazole is... | Nizoral | 1976 | 1981 |
| R43512 | astemizole Astemizole Astemizole was a second generation antihistamine drug which has a long duration of action. Astemizole was discovered by Janssen Pharmaceutica in 1977... | Hismanal | 1977 | 1983 |
| R46541 | bromperidol decanoate Bromperidol Bromperidol is a drug which is a butyrophenone derivative. It is a potent and long-acting neuroleptic, used as an antipsychotic in the treatment of schizophrenia. It was discovered at Janssen Pharmaceutica in 1966.- References :... | Impromen decanoas | 1978 | 1984 |
| R49945 | ketanserin tartrate Ketanserin Ketanserin is a drug with affinity for multiple G protein-coupled receptors . Initially it was believed to be a highly selective antagonist for serotonin 5-HT2A receptors, however this is not true. Ketanserin only has moderate selectivity for 5-HT2A receptors over 5-HT2C receptors... | Sufrexal | 1980 | 1987 |
| R30490 or R32395 | lofentanil Lofentanil Lofentanil is one of the most potent opioid analgesics known and is an analogue of fentanyl, which was developed in 1960. It is most similar to the highly potent opioid carfentanil , only slightly more potent. Lofentanil can be described as 3-methylcarfentanil, or 3-methyl-4-carbomethoxyfentanyl... | ? | 1980? | ? |
| R50547 | levocabastine Levocabastine Levocabastine is a selective second-generation H1-receptor antagonist which was discovered at Janssen Pharmaceutica in 1979. It is used for allergic conjunctivitis.... | Livostin | 1979 | 1989 |
| R51211 | itraconazole Itraconazole Itraconazole , invented in 1984, is a triazole antifungal agent that is prescribed to patients with fungal infections. The drug may be given orally or intravenously.-Medical uses:... | Sporanox | 1980 | 1986 |
| R51619 | cisapride Cisapride Cisapride is a gastroprokinetic agent, a drug which increases motility in the upper gastrointestinal tract. It acts directly as a serotonin 5-HT4 receptor agonist and indirectly as a parasympathomimetic. Stimulation of the serotonin receptors increases acetylcholine release in the enteric nervous... | Prepulsid | 1980 | 1989 |
| R64766 | risperidone Risperidone Risperidone is a second generation or atypical antipsychotic, sold under the trade name . It is used to treat schizophrenia , schizoaffective disorder, the mixed and manic states associated with bipolar disorder, and irritability in people with autism... | Risperdal | 1984 | 1993 |
Janssen Pharmaceutica has developed and brought to the market about 70 new active substances (NCE
New chemical entity
A new chemical entity , or new molecular entity , is, according to the U.S. Food and Drug Administration, a drug that contains no active moiety that has been approved by the FDA in any other application submitted under section 505 of the Federal Food, Drug, and Cosmetic Act.An active moiety is a...
), of which the most well-known are (name may differ):
- Imodium (against diarrhoea. Active substance: loperamideLoperamideLoperamide , a synthetic piperidine derivative, is an opioid drug used against diarrhea resulting from gastroenteritis or inflammatory bowel disease. In most countries it is available generically and under brand names such as Lopex, Imodium, Dimor, Fortasec, and Pepto Diarrhea Control...
) - Motilium (against flatulence — and bowel impairments. Active substance: domperidoneDomperidoneDomperidone is an antidopaminergic drug, developed by Janssen Pharmaceutica, and used orally, rectally or intravenously, generally to suppress nausea and vomiting, or as a prokinetic agent...
) - Reminyl (against Alzheimer's diseaseAlzheimer's diseaseAlzheimer's disease also known in medical literature as Alzheimer disease is the most common form of dementia. There is no cure for the disease, which worsens as it progresses, and eventually leads to death...
(dementia). Active substance: galantamineGalantamineGalantamine is used for the treatment of mild to moderate Alzheimer’s disease and various other memory impairments, in particular those of vascular origin...
) - Daktarin (against fungal infections. Active substance: miconazoleMiconazoleMiconazole is an imidazole antifungal agent, developed by Janssen Pharmaceutica, commonly applied topically to the skin or to mucus membranes to cure fungal infections. It works by inhibiting the synthesis of ergosterol, a critical component of fungal cell membranes...
) - Nizoral (against dandruffDandruffDandruff is the shedding of dead skin cells from the scalp . Dandruff is sometimes caused by frequent exposure to extreme heat and cold. As it is normal for skin cells to die and flake off, a small amount of flaking is normal and common; about 487,000 cells/cm2 get released normally after...
, Active substance: ketoconazoleKetoconazoleKetoconazole is a synthetic antifungal drug used to prevent and treat fungal skin infections, especially in immunocompromised patients such as those with AIDS or those on chemotherapy. Ketoconazole is sold commercially as an anti-dandruff shampoo, topical cream, and oral tablet.Ketoconazole is...
) - DurogesicDuragesicDuragesic and Durogesic are trade names of fentanyl transdermal therapeutic systems, and are used for relief of moderate to severe pain. Since Duragesic/Durogesic release Fentanyl, a potent opioid, slowly through the skin, one patch may provide 72 hours of pain relief...
(fentanyl patch for pain suppression. Active substance: fentanyl) - Vermox (against worms. Active substance: mebendazoleMebendazoleMebendazole or MBZ is a benzimidazole drug developed by Janssen Pharmaceutica and marketed as Vermox, Ovex, Antiox, and Pripsen...
) - Risperdal (antipsychotic, against mental illness such as schizophrenia. Active substance: risperidoneRisperidoneRisperidone is a second generation or atypical antipsychotic, sold under the trade name . It is used to treat schizophrenia , schizoaffective disorder, the mixed and manic states associated with bipolar disorder, and irritability in people with autism...
)
Five drugs of Janssen Pharmaceutica have been included on the WHO Model List of Essential Medicines:
- Haldol (haloperidolHaloperidolHaloperidol is a typical antipsychotic. It is in the butyrophenone class of antipsychotic medications and has pharmacological effects similar to the phenothiazines....
) - Ergamisol (levamisoleLevamisoleLevamisole is an anthelminthic and immunomodulator belonging to a class of synthetic imidazothiazole derivatives. It was discovered at Janssen Pharmaceutica in 1966...
) - Daktarin (miconazoleMiconazoleMiconazole is an imidazole antifungal agent, developed by Janssen Pharmaceutica, commonly applied topically to the skin or to mucus membranes to cure fungal infections. It works by inhibiting the synthesis of ergosterol, a critical component of fungal cell membranes...
) - Vermox (mebendazoleMebendazoleMebendazole or MBZ is a benzimidazole drug developed by Janssen Pharmaceutica and marketed as Vermox, Ovex, Antiox, and Pripsen...
) - Nizoral (ketoconazoleKetoconazoleKetoconazole is a synthetic antifungal drug used to prevent and treat fungal skin infections, especially in immunocompromised patients such as those with AIDS or those on chemotherapy. Ketoconazole is sold commercially as an anti-dandruff shampoo, topical cream, and oral tablet.Ketoconazole is...
) (on the WHO list until 2005)
R207910
R207910
R207910 is an experimental diarylquinoline anti-tuberculosis drug, which was discovered by Koen Andries and his team at Janssen Pharmaceutica...
is an experimental diarylquinoline anti-tuberculosis drug, discovered by Koen Andries
Koen Andries
Koen Andries is a Belgian scientist working at Janssen Pharmaceutica and professor at the University of Antwerp. In 2005 he and his team published a discovery about a new di-Aryl-Quinoline-based drug which promises a shorter and simpler treatment for Tuberculosis .-Career:He graduated as a...
and his team, which promises a shorter and simpler treatment
Tuberculosis treatment
Tuberculosis treatment refers to the medical treatment of the infectious disease tuberculosis .The standard "short" course treatment for TB is isoniazid, rifampicin , pyrazinamide, and ethambutol for two months, then isoniazid and rifampicin alone for a further four months...
for Tuberculosis
Tuberculosis
Tuberculosis, MTB, or TB is a common, and in many cases lethal, infectious disease caused by various strains of mycobacteria, usually Mycobacterium tuberculosis. Tuberculosis usually attacks the lungs but can also affect other parts of the body...
(TB).
See also
- Didier de Chaffoy de CourcellesDidier de Chaffoy de CourcellesDidier R.G.G. de Chaffoy de Courcelles is a Belgian scientist and businessman. He is Senior Vice President of Drug Discovery Europe, and Johnson & Johnson Pharmaceutical Research & Development , a division of Janssen Pharmaceutica .-Education:Didier de Chaffoy de Courcelles went to highschool at...
- Paul StoffelsPaul StoffelsPaul Stoffels is a Belgian MD, who studied Medicine at the University of Hasselt and the University of Antwerp . In addition he studied Infectious Diseases and Tropical Medicine at the Prince Leopold Institute of Tropical Medicine in Antwerp, Belgium...
- Staf Van ReetStaf Van ReetStaf Van Reet is a Belgian scientist and businessman. Currently he is Managing Director of the biotech company Viziphar Biosciences BVBA, and member of the Board of Directors of Janssen Pharmaceutica and the VIB. He was succeeded as Chairman of FlandersBio by Johan Cardoen.-Education:He obtained a...
- Jan SchuurkesJan SchuurkesJan A. J. Schuurkes is a Dutch biologist and gastrointestinal researcher.-Education:He graduated as a biochemist at the Catholic University of Nijmegen...
- TibotecTibotecTibotec is a pharmaceutical company with a focus on research and development for the treatment of infectious diseases such as HIV , and Hepatitis C...
- VircoVircoVirco was a biotech company located in Mechelen, Belgium. It provides a quantitative phenotype prediction for HIV resistance testing. The prediction is achieved by performing a search in a database of genotype-phenotype pairs and matching the mutations in the database with those of the sample of...
- Rega Institute for Medical ResearchRega Institute for Medical ResearchThe Rega Institute for Medical Research is a Belgian scientific establishment that is part of the Catholic University of Leuven in central Belgium...
- Drug developmentDrug developmentDrug development is a blanket term used to define the process of bringing a new drug to the market once a lead compound has been identified through the process of drug discovery...
- Nanovid microscopyNanovid microscopyNanovid microscopy, from “nanometer video-enhanced microscopy”, is a microscopic technique aimed at visualizing colloidal gold particles of 20-40 nm diameter as dynamic markers at the light microscopic level...
- FlandersBioFlandersBioFlandersBio is a non-profit organization which represents the cluster of Flemish life sciences in Belgium. The members of FlandersBio are organizations involved with Research and Development, and production in life sciences, or organizations and companies servicing Flemish life sciences...
- Joan DaemenJoan DaemenJoan Daemen |Limburg]], Belgium) is a Belgian cryptographer and one of the designers of Rijndael, the Advanced Encryption Standard , together with Vincent Rijmen. He has also designed or co-designed the MMB, Square, SHARK, NOEKEON, 3-Way, and BaseKing block ciphers...
- List of companies of Belgium
- List of pharmaceutical companies
Source
- Magiels, Geerdt (2004). Paul Janssen – Pionier in farma en in China (in DutchDutch languageDutch is a West Germanic language and the native language of the majority of the population of the Netherlands, Belgium, and Suriname, the three member states of the Dutch Language Union. Most speakers live in the European Union, where it is a first language for about 23 million and a second...
). Antwerp, AmsterdamAmsterdamAmsterdam is the largest city and the capital of the Netherlands. The current position of Amsterdam as capital city of the Kingdom of the Netherlands is governed by the constitution of August 24, 1815 and its successors. Amsterdam has a population of 783,364 within city limits, an urban population...
: Houtekiet. ISBN 978-9-052-40827-9.