Trifluperidol
Encyclopedia
Trifluperidol is a typical antipsychotic
of the butyrophenone
chemical class. It has general properties similar to those of haloperidol
, but is considerably more potent by weight, and causes relatively more severe side effects, especially tardive dyskinesia
and other extrapyramidal
effects. It is used in the treatment of psychoses including mania
and schizophrenia
. It was discovered at Janssen Pharmaceutica
in 1959.
Typical antipsychotic
Typical antipsychotics are a class of antipsychotic drugs first developed in the 1950s and used to treat psychosis...
of the butyrophenone
Butyrophenone
Butyrophenone is a chemical compound ; some of its derivatives are used to treat various psychiatric disorders such as schizophrenia, as well as acting as antiemetics....
chemical class. It has general properties similar to those of haloperidol
Haloperidol
Haloperidol is a typical antipsychotic. It is in the butyrophenone class of antipsychotic medications and has pharmacological effects similar to the phenothiazines....
, but is considerably more potent by weight, and causes relatively more severe side effects, especially tardive dyskinesia
Tardive dyskinesia
Tardive dyskinesia is a difficult-to-treat form of dyskinesia that can be tardive...
and other extrapyramidal
Extrapyramidal
Extrapyramidal can refer to:* Extrapyramidal system* Extrapyramidal symptoms...
effects. It is used in the treatment of psychoses including mania
Mania
Mania, the presence of which is a criterion for certain psychiatric diagnoses, is a state of abnormally elevated or irritable mood, arousal, and/ or energy levels. In a sense, it is the opposite of depression...
and schizophrenia
Schizophrenia
Schizophrenia is a mental disorder characterized by a disintegration of thought processes and of emotional responsiveness. It most commonly manifests itself as auditory hallucinations, paranoid or bizarre delusions, or disorganized speech and thinking, and it is accompanied by significant social...
. It was discovered at Janssen Pharmaceutica
Janssen Pharmaceutica
Janssen Pharmaceutica is pharmaceutical company, established in Belgium in 1953 by Paul Janssen. Its headquarters are located in Beerse, in the Campine region of the province of Antwerp, Belgium. It was created not as a subsidiary of a chemical factory but solely with the aim of conducting...
in 1959.
Chemistry
- P. Janssen, J. Adriaan, (1962).
- P. Janssen, J. Adriaan, (1969).