Lexitropsins is a family of semi-synthetic DNA

DNA

Deoxyribonucleic acid is a nucleic acid that contains the genetic instructions used in the development and functioning of all known living organisms . The DNA segments that carry this genetic information are called genes, but other DNA sequences have structural purposes, or are involved in...

-binding ligands.
They are analogs of natural antibiotics Netropsin

Netropsin

Netropsin is an oligopeptide with antibiotic and antiviral activity.Netropsin was discovered by Finlay et al. and first isolated from the actinobacterium Streptomyces netropsis. It belongs to the class of pyrrole-amidine antibiotics...

 and Distamycin. Antibiotics of this group are capable to bind with a narrow groove of DNA with different sequence-selectivity. Lexitropsins form a complexes with DNA with stoichiometry

Stoichiometry

Stoichiometry is a branch of chemistry that deals with the relative quantities of reactants and products in chemical reactions. In a balanced chemical reaction, the relations among quantities of reactants and products typically form a ratio of whole numbers...

 1:1 and 2:1. Based on the 2:1 complexes were obtained ligands with high sequence-selectivity.

See also

• Netropsin
  Netropsin
  Netropsin is an oligopeptide with antibiotic and antiviral activity.Netropsin was discovered by Finlay et al. and first isolated from the actinobacterium Streptomyces netropsis. It belongs to the class of pyrrole-amidine antibiotics...
  
  
• Hoechst 33258
• Pentamidine
  Pentamidine
  Pentamidine is an antimicrobial medication given for prevention and treatment of Pneumocystis pneumonia caused by Pneumocystis jirovecii , a severe interstitial type of pneumonia often seen in patients with HIV infection...
  
  
• DNA-binding protein
  DNA-binding protein
  DNA-binding proteins are proteins that are composed of DNA-binding domains and thus have a specific or general affinity for either single or double stranded DNA. Sequence-specific DNA-binding proteins generally interact with the major groove of B-DNA, because it exposes more functional groups that...
  
  
• Single-strand binding protein
  Single-strand binding protein
  Single-strand binding protein, also known as SSB or SSBP, binds to single stranded regions of DNA to prevent premature annealing. The strands have a natural tendency to revert to the duplex form, but SSB binds to the single strands, keeping them separate and allowing the DNA replication machinery...
  
  
• Nucleic acid simulations