Linker dna
Encyclopedia
Linker DNA is double-stranded DNA
in between two nucleosome
cores that, in association with histone H1
, holds the cores together. Linker DNA is seen as the string in the "beads and string model," which is made by using an ionic solution on the chromatin. Linker DNA connects to histone H1 and histone H1 sits on the nucleosome core. Linker DNA is not associated with the transcribable DNA wrapped around the core. Nucleosome is technically the consolidation of a nucleosome core and one adjacent linker DNA; however, the term nucleosome is used freely for solely the core. Linker DNA may be degraded by endonuclease
s.
DNA
Deoxyribonucleic acid is a nucleic acid that contains the genetic instructions used in the development and functioning of all known living organisms . The DNA segments that carry this genetic information are called genes, but other DNA sequences have structural purposes, or are involved in...
in between two nucleosome
Nucleosome
Nucleosomes are the basic unit of DNA packaging in eukaryotes, consisting of a segment of DNA wound around a histone protein core. This structure is often compared to thread wrapped around a spool....
cores that, in association with histone H1
Histone H1
Histone H1 is one of the five main histone protein families which are components of chromatin in eukaryotic cells. Though highly conserved, it is nevertheless the most variable histone in sequence across species.- Structure :...
, holds the cores together. Linker DNA is seen as the string in the "beads and string model," which is made by using an ionic solution on the chromatin. Linker DNA connects to histone H1 and histone H1 sits on the nucleosome core. Linker DNA is not associated with the transcribable DNA wrapped around the core. Nucleosome is technically the consolidation of a nucleosome core and one adjacent linker DNA; however, the term nucleosome is used freely for solely the core. Linker DNA may be degraded by endonuclease
Endonuclease
Endonucleases are enzymes that cleave the phosphodiester bond within a polynucleotide chain, in contrast to exonucleases, which cleave phosphodiester bonds at the end of a polynucleotide chain. Typically, a restriction site will be a palindromic sequence four to six nucleotides long. Most...
s.