Lloyd Mayer
Encyclopedia
Lloyd Mayer, is an American
gastroenterologist
and immunologist
. He is Professor and Co-Director of the Immunology institute at the Mount Sinai Medical Center
Mayer's research on inflammatory bowel disease
pathogenesis
was among the first to demonstrate the role played by T-regulatory cells
in setting the stage for chronic mucosal inflammation (IBD). He was the first to describe the role of T cell
s in immunoglobulin class switching
and to identify a novel T-cell-derived cytokine
(446-BCDF) that stimulates antibody secretion by human B cell
s.
Mayer is Professor and Co-Director of the Immunology institute at the Mount Sinai Medical Center
and the Dorothy and David Merksamer Professor of Medicine, as well as Professor of Microbiology at the Mount Sinai School of Medicine
.
Mayer is the author of multiple book chapters and close to 200 peer-reviewed papers. He has been included in New York Magazine
’s list of Best Doctors since its inception in the 1990s.
in with a degree in Biology and earned his medical degree from the Mount Sinai School of Medicine in 1976. He completed an internship and a residency in Internal Medicine at Bellevue Hospital Center
/New York University
and a fellowship in Gastroenterology at the Mount Sinai Medical Center in 1981.
Mayer held an appointment at the Rockefeller University
from 1980–1984, first as a post-doctoral fellow then Assistant Professor. He was Associate Professor of Medicine and Microbiology at Mount Sinai Medical Center from 1985–1986 and was named Director of the Division of Clinical Immunology in 1986. He was named Professor of both Medicine and Microbiology in 1990, then Vice Chair of Medicine. In 1994, he became the David and Dorothy Merksamer Chair of Medicine, and in 1997, Professor of Immunobiology and Chair of Mount Sinai's Immunobiology Center.
From 1992–1997, Mayer served on the Immunological Sciences Study Section of the National Institutes of Health
.
Mayer served as Director of the Mount Sinai's Division of Gastroenterology from 2003–2010. In 2007, he was named Co-Director of Mount Sinai's Immunology Institute. He has served as Chairman of the National Scientific Advisory Committee of the Crohn's & Colitis Foundation of America since 2008.
Mayer was elected to the American Society for Clinical Investigation
in 1991 and the Association of American Physicians
in 1997. He is currently a member of the American Board of Internal Medicine
and Gastroenterology.
United States
The United States of America is a federal constitutional republic comprising fifty states and a federal district...
gastroenterologist
Gastroenterology
Gastroenterology is the branch of medicine whereby the digestive system and its disorders are studied. The name is a combination of three Ancient Greek words gaster , enteron , and logos...
and immunologist
Immunology
Immunology is a broad branch of biomedical science that covers the study of all aspects of the immune system in all organisms. It deals with the physiological functioning of the immune system in states of both health and diseases; malfunctions of the immune system in immunological disorders ; the...
. He is Professor and Co-Director of the Immunology institute at the Mount Sinai Medical Center
Mount Sinai Hospital, New York
Mount Sinai Hospital, founded in 1852, is one of the oldest and largest teaching hospitals in the United States. In 2011-2012, Mount Sinai Hospital was ranked as one of America's best hospitals by U.S...
Mayer's research on inflammatory bowel disease
Inflammatory bowel disease
In medicine, inflammatory bowel disease is a group of inflammatory conditions of the colon and small intestine. The major types of IBD are Crohn's disease and ulcerative colitis.-Classification:...
pathogenesis
Pathogenesis
The pathogenesis of a disease is the mechanism by which the disease is caused. The term can also be used to describe the origin and development of the disease and whether it is acute, chronic or recurrent...
was among the first to demonstrate the role played by T-regulatory cells
Regulatory T cell
Regulatory T cells , sometimes known as suppressor T cells, are a specialized subpopulation of T cells which suppresses activation of the immune system and thereby maintains tolerance to self-antigens. The existence of regulatory T cells was the subject of significant controversy among...
in setting the stage for chronic mucosal inflammation (IBD). He was the first to describe the role of T cell
T cell
T cells or T lymphocytes belong to a group of white blood cells known as lymphocytes, and play a central role in cell-mediated immunity. They can be distinguished from other lymphocytes, such as B cells and natural killer cells , by the presence of a T cell receptor on the cell surface. They are...
s in immunoglobulin class switching
Immunoglobulin class switching
Immunoglobulin class switching is a biological mechanism that changes a B cell's production of antibody from one class to another, for example, from an isotype called IgM to an isotype called IgG...
and to identify a novel T-cell-derived cytokine
Cytokine
Cytokines are small cell-signaling protein molecules that are secreted by the glial cells of the nervous system and by numerous cells of the immune system and are a category of signaling molecules used extensively in intercellular communication...
(446-BCDF) that stimulates antibody secretion by human B cell
B cell
B cells are lymphocytes that play a large role in the humoral immune response . The principal functions of B cells are to make antibodies against antigens, perform the role of antigen-presenting cells and eventually develop into memory B cells after activation by antigen interaction...
s.
Mayer is Professor and Co-Director of the Immunology institute at the Mount Sinai Medical Center
Mount Sinai Hospital, New York
Mount Sinai Hospital, founded in 1852, is one of the oldest and largest teaching hospitals in the United States. In 2011-2012, Mount Sinai Hospital was ranked as one of America's best hospitals by U.S...
and the Dorothy and David Merksamer Professor of Medicine, as well as Professor of Microbiology at the Mount Sinai School of Medicine
Mount Sinai School of Medicine
Mount Sinai School of Medicine is an American medical school in the borough of Manhattan in New York City, currently ranked among the top 20 medical schools in the United States. It was chartered by Mount Sinai Hospital in 1963....
.
Mayer is the author of multiple book chapters and close to 200 peer-reviewed papers. He has been included in New York Magazine
New York (magazine)
New York is a weekly magazine principally concerned with the life, culture, politics, and style of New York City. Founded by Milton Glaser and Clay Felker in 1968 as a competitor to The New Yorker, it was brasher and less polite than that magazine, and established itself as a cradle of New...
’s list of Best Doctors since its inception in the 1990s.
Biography
Mayer was born in 1952. He graduated from Union CollegeUnion College
Union College is a private, non-denominational liberal arts college located in Schenectady, New York, United States. Founded in 1795, it was the first institution of higher learning chartered by the New York State Board of Regents. In the 19th century, it became the "Mother of Fraternities", as...
in with a degree in Biology and earned his medical degree from the Mount Sinai School of Medicine in 1976. He completed an internship and a residency in Internal Medicine at Bellevue Hospital Center
Bellevue Hospital Center
Bellevue Hospital Center, most often referred to as "Bellevue", was founded on March 31, 1736 and is the oldest public hospital in the United States. Located on First Avenue in the Kips Bay neighborhood of Manhattan, New York City, Bellevue is famous from many literary, film and television...
/New York University
New York University
New York University is a private, nonsectarian research university based in New York City. NYU's main campus is situated in the Greenwich Village section of Manhattan...
and a fellowship in Gastroenterology at the Mount Sinai Medical Center in 1981.
Mayer held an appointment at the Rockefeller University
Rockefeller University
The Rockefeller University is a private university offering postgraduate and postdoctoral education. It has a strong concentration in the biological sciences. It is also known for producing numerous Nobel laureates...
from 1980–1984, first as a post-doctoral fellow then Assistant Professor. He was Associate Professor of Medicine and Microbiology at Mount Sinai Medical Center from 1985–1986 and was named Director of the Division of Clinical Immunology in 1986. He was named Professor of both Medicine and Microbiology in 1990, then Vice Chair of Medicine. In 1994, he became the David and Dorothy Merksamer Chair of Medicine, and in 1997, Professor of Immunobiology and Chair of Mount Sinai's Immunobiology Center.
From 1992–1997, Mayer served on the Immunological Sciences Study Section of the National Institutes of Health
National Institutes of Health
The National Institutes of Health are an agency of the United States Department of Health and Human Services and are the primary agency of the United States government responsible for biomedical and health-related research. Its science and engineering counterpart is the National Science Foundation...
.
Mayer served as Director of the Mount Sinai's Division of Gastroenterology from 2003–2010. In 2007, he was named Co-Director of Mount Sinai's Immunology Institute. He has served as Chairman of the National Scientific Advisory Committee of the Crohn's & Colitis Foundation of America since 2008.
Mayer was elected to the American Society for Clinical Investigation
American Society for Clinical Investigation
The American Society for Clinical Investigation, or ASCI, established in 1908, is one of the nation's oldest and most respected medical honor societies.-Organization and Purpose:...
in 1991 and the Association of American Physicians
Association of American Physicians
The Association of American Physicians is a medical society founded in 1885 by the Canadian physician Sir William Osler and six other distinguished physicians of his era, for "the advancement of scientific and practical medicine." Election to the AAP is an honor extended to individuals with...
in 1997. He is currently a member of the American Board of Internal Medicine
American Board of Internal Medicine
The American Board of Internal Medicine is a non-profit, independent physician evaluation organization committed to continuously improving the profession for the public good by certifying physicians who practice internal medicine and its sub-specialties...
and Gastroenterology.
Honors and awards
- Sigma XiSigma XiSigma Xi: The Scientific Research Society is a non-profit honor society which was founded in 1886 at Cornell University by a junior faculty member and a handful of graduate students. Members elect others on the basis of their research achievements or potential...
(Science Honor Society), 1972 - Alpha Omega AlphaAlpha Omega AlphaThe Alpha Omega Alpha Honor Medical Society, commonly called Alpha Omega Alpha and abbreviated ΑΩΑ or AOA, is a national honor society for medical students, residents, scientists and physicians in the United States and Canada.-History:...
, 1975 and 1976 - Mosby Award for Clinical Excellence, 1976
- Irma T. Hirschl Trust Award, 1986
- Saul Horowitz, Jr. Award, 1986
- Jeffrey Modell Foundation Lifetime Achievement Award, 1990
- American Society for Clinical InvestigationAmerican Society for Clinical InvestigationThe American Society for Clinical Investigation, or ASCI, established in 1908, is one of the nation's oldest and most respected medical honor societies.-Organization and Purpose:...
, 1991 - Immunological Sciences Study section, 1992–1997
- Association of American PhysiciansAssociation of American PhysiciansThe Association of American Physicians is a medical society founded in 1885 by the Canadian physician Sir William Osler and six other distinguished physicians of his era, for "the advancement of scientific and practical medicine." Election to the AAP is an honor extended to individuals with...
, 1997 - Jaffe Food Allergy Institute Scientific Achievement Award, 1998
- Scientific Achievement Award, Crohn's and Colitis Foundation of AmericaCrohn's and Colitis Foundation of AmericaThe Crohn’s & Colitis Foundation of America is a non-profit organization, founded in 1967, whose mission is to cure Crohn’s disease and ulcerative colitis and to improve the quality of life of children and adults affected by these digestive diseases.Supported by individual, foundation and...
, 2000 - Jacobi Medallion, 2002
- Scientific Achievement in IBD: Basic Research Award, Crohn's & Colitis Foundation of America, 2010
Grants
A partial list of active grants on which Mayer is a principal or co-investigator:- Immunologic Basis of Cow Milk-Induced Hypersensitivities, NIH/NIAD, 5 U19 AI044236-11
- Innate/Adaptive Immune Interaction in Gut Inflammation, NIH/NIDDK, 5 P01 DK072201-04
- Cellular & Molecular Defects in Human B Cell Development, NIH/NIAID, 5 P01 AI061093-05
- Immunobiology of Peanut Allergy and its Treatment: A Prototype, NIH/NIAID, 1 U19 AI066738-03
- Epithelial TLR Signaling and IgA Production, NIH/NIAID, 1 R21 AI083381-01
- Oral Vaccine Platform for Class A Bacterial Agents, NIH, 1 R01 AI084952
- Generation and Characterization of Intestinal CD8+ Regulatory T cell lines, NIH 1 RC1 DK086605
Clinical trials
Active clinical trials include:- InfliximabInfliximabInfliximab is a monoclonal antibody against tumour necrosis factor alpha . It is used to treat autoimmune diseases. Remicade is marketed by Janssen Biotech, Inc...
for post-op recurrence of Crohn's disease
Publications
Partial list:- Blázquez AB, Knight AK, Getachew H, Bromberg JS, Lira SASergio A. LiraSergio A. Lira, M.D., PhD., is an immunologist who pioneered the use of genetic approaches to study the function of chemokines. His early studies were the first to show that chemokines played a major role on leukocyte trafficking to the brain, the lung and the thymus.Lira is currently the Leona M....
, Mayer L, Berin MC. A Functional Role for CCR6 on Proallergic T Cells in the Gastrointestinal Tract.. Gastroenterology. 2010. 138:275-284 PMID 19782082 - Sicherer SH, Wood RA, Stablein D, Burks AW, Liu AH, Jones SM, Fleischer DM, Leung DY, Grishin A, Mayer L, Shreffler W, Lindblad R, Sampson HA. Immunologic features of infants with milk or egg allergy enrolled in an observational study (Consortium of Food Allergy Research) of food allergy. J Allergy Clin Immunol. 2010 125:1077-1083 PMID 20451041
- WJ Sandborn, J-F Colombel, M Frankel, D Hommes, J Lowder, L Mayer, S Plevy, P Stokkers, S Travis, G Van Assche, D Baumgart, and S Targan. 2010. Anti-CD3 Antibody Visilizumab is Not Effective in Patients with Intravenous Corticosteroid-Refractory Ulcerative Colitis. Gut 59:1485-92 PMID 20947884
- Blázquez AB, Mayer L, Berin MC. 2010. Thymic Stromal Lymphopoietin is Required for Gastrointestinal Allergy but not Oral Tolerance. Gastroenterology 138:275-84 PMID 20600023
- Murphy SJ, Mayer L, Abreu MT. 2010. Mesalamine (5-Aminosalicylic Acid) Therapy Well Tolerated in a Patient With Aspirin Hypersensitivity and Ulcerative Colitis. J Clin Gastroenterol. 45(1):83-4 PMID 20535023
- Roda G, Caponi A, Benevento M, Nanni P, Mezzanotte L, Belluzzi A, Mayer L, Roda A. 2010. New proteomic approaches for biomarker discovery in inflammatory bowel disease. Inflamm Bowel Dis. 16:1239-46. PMID 20127998
- Baumgart DC, Targan SR, Dignass AU, Mayer L, van Assche G, Hommes DW, Hanauer SB, Mahadevan U, Reinisch W, Plevy SE, Salzberg BA, Buchman AL, Mechkov GM, Krastev ZA, Lowder JN, Frankel MB, Sandborn WJ. 2010. Prospective randomized open-label multicenter phase I/II dose escalation trial of visilizumab (HuM291) in severe steroid-refractory ulcerative colitis. Inflamm Bowel Dis. 16:620-9. PMID 19714757
- Viejo-Borbolla A, AP Martin, LR Muniz, L Shang, F Marchesi, N Thirunarayanan, N Harpaz, RA Garcia, M Apostolaki, GC Furtado, L Mayer, G Kollias, A Alcami, and SA Lira. 2010. Attenuation of TNF-driven murine ileitis by intestinal expression of the viral immunomodulator CrmD. Mucosal Immunology 3:633-44 PMID 20664576
- Bongers G, D Maussang, LR Muniz, VM Noriega, A Fraile-Ramos, N Barker, F Marchesi, N Thirunarayanan, HF Vischer, L Qin, L Mayer, N Harpaz, R Leurs, GC Furtado,H Clevers, D Tortorella, MJ Smit,2 and SA Lira. 2010. The cytokine-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic mice. JCI 120:3969-78 PMID 20978345
- Yu JE, De Ravin SS, Uzel G, Landers C, Targan S, Malech HL, Holland SM, Cao W, Harpaz N, Mayer L, Cunningham-Rundles C. 2011. High Levels of Crohn's Disease-Associated Anti-Microbial Antibodies Are Present and Independent of Colitis in Chronic Granulomatous Disease Clin Immunol 138(1):14-22. PMID 20956091
- Dahan S, K Rabinowitz, AP Martin, MC Berin, JC Unkeless and L Mayer. 2011. The Notch-1 signaling pathway regulates intestinal epithelial barrier function in mice and humans through interaction with CD4+ T cells. Gastroenterology 140:550-9 PMID 21056041
- Fukata, M, L Shang, R Santaolalla, JSotolongo, C Pastorini, C España, R Ungaro, N Harpaz, HS Cooper, G Elson, M Kosco-Vilbois, J Zaias, MT. Perez, L Mayer, AS Vamadevan, SA Lira and MT. Abreu. 2011. Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis-associated tumorigenesis IBD Journal in press PMID 21674704
- Hovhannisyan Z, J Treatman, D Littman and L Mayer. 2011. Characterization of IL-17-producing regulatory T cells in inflamed gut mucosa. Gastroenterology 140(3):957-65 PMID 21147109
- Dotan, I, L Werner, S Vigodman, S Agarwal, J Pfeffer, N Horowitz, L Malter, M Abreu, T Ullman, H Guzner-Gur, Z Halpern, L Mayer. 2011. Normal Response to Vaccines in Inflammatory Bowel Disease Patients Treated with Thiopurines. IBD Journal in press PMID 21438101
- Dunkin D, M. C Berin, and L Mayer. 2011. Allergic Sensitization to Cow’s Milk Antigens Can Be Induced via Multiple Physiologic Routes in an Adjuvant-Dependent Manner. JACI in press PMID 21762973
- Ouyang X, R Zhang, J Yang, Q Li, L Qin, C Zhu, J Liu, H Ning, MS Shin, M Gupta, C-F Qi, JC He, SA Lira, HC Morse III, K Ozato, L Mayer and H Xiong. 2011. Transcription factor IRF8 directs a silencing program for TH17 cell differentiation. Nature Communications 2:314 PMID 21587231