MAP2K2
Encyclopedia
Dual specificity mitogen-activated protein kinase kinase 2 is an enzyme
that in humans is encoded by the MAP2K2 gene
.
. It phosphorylates and thus activates MAPK1
/ERK2 and MAPK2/ERK3.
The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinase
s.
The inhibition or degradation of this kinase is found to be involved in the pathogenesis of Yersinia and anthrax.
with MAPK3
and ARAF
.
Enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
that in humans is encoded by the MAP2K2 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Function
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transductionMAPK/ERK pathway
The MAPK/ERK pathway is a chain of proteins in the cell that communicates a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell. The signal starts when a growth factor binds to the receptor on the cell surface and ends when the DNA in the nucleus expresses a...
. It phosphorylates and thus activates MAPK1
MAPK1
Mitogen-activated protein kinase 1, also known as MAPK1, p42MAPK, and ERK2, is an enzyme that in humans is encoded by the MAPK1 gene.- Function :The protein encoded by this gene is a member of the MAP kinase family...
/ERK2 and MAPK2/ERK3.
The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinase
MAP kinase kinase kinase
MAP kinase kinase kinase is a serine/threonine-specific protein kinase which acts upon MAP kinase kinase.In humans there are at least 19 genes:* MAP3K1 * MAP3K2* MAP3K3 * MAP3K4* MAP3K5...
s.
The inhibition or degradation of this kinase is found to be involved in the pathogenesis of Yersinia and anthrax.
Interactions
MAP2K2 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with MAPK3
MAPK3
Mitogen-activated protein kinase 3 is an enzyme that in humans is encoded by the MAPK3 gene.-Interactions:MAPK3 has been shown to interact with PTPN7, SPIB, GTF2I, DUSP3, HDAC4, RPS6KA2, MAP2K1, DUSP6 and MAP2K2.-Further reading:...
and ARAF
ARAF
Serine/threonine-protein kinase A-Raf or simply A-Raf is an enzyme that in humans is encoded by the ARAF gene. A-Raf is a member of the Raf kinase family of serine/threonine-specific protein kinases.-Interactions:...
.