MAPK14
Encyclopedia
Mitogen-activated protein kinase 14, also called p38-α, is an enzyme
that in humans is encoded by the MAPK14 gene
.
with Casein kinase 2, alpha 1, RPS6KA4
, MAPKAPK2
, CDC25B
, DUSP1
, ZFP36L1
, CDC25C
, MAPKAPK3
, Activating transcription factor 2
, MAPK1
, AKT1
, Myocyte-specific enhancer factor 2A
, MAP3K7IP1
, DUSP16
, HtrA serine peptidase 2
, DUSP10
, Far upstream element-binding protein 1
, Keratin 8
and MAP2K6
.
Enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
that in humans is encoded by the MAPK14 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Interactions
MAPK14 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with Casein kinase 2, alpha 1, RPS6KA4
RPS6KA4
Ribosomal protein S6 kinase alpha-4 is an enzyme that in humans is encoded by the RPS6KA4 gene.- Function :This gene encodes a member of the RSK family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1...
, MAPKAPK2
MAPKAPK2
MAP kinase-activated protein kinase 2 is an enzyme that in humans is encoded by the MAPKAPK2 gene.-Interactions:MAPKAPK2 has been shown to interact with MAPK14, AKT1, PHC2 and SHC1.-Further reading:...
, CDC25B
CDC25B
M-phase inducer phosphatase 2 is an enzyme that in humans is encoded by the CDC25B gene.-Interactions:CDC25B has been shown to interact with MAPK14, Casein kinase 2, alpha 1, CHEK1, MELK, Estrogen receptor alpha, YWHAB, YWHAZ, YWHAH and YWHAE....
, DUSP1
DUSP1
Dual specificity protein phosphatase 1 is an enzyme that in humans is encoded by the DUSP1 gene.-Interactions:DUSP1 has been shown to interact with MAPK14, MAPK1 and MAPK8.-Further reading:...
, ZFP36L1
ZFP36L1
Butyrate response factor 1 is a protein that in humans is encoded by the ZFP36L1 gene.-Further reading:...
, CDC25C
CDC25C
M-phase inducer phosphatase 3 is an enzyme that in humans is encoded by the CDC25C gene.-Interactions:CDC25C has been shown to interact with MAPK14, CHEK1, PCNA, PIN1, PLK3 and NEDD4.-Further reading:...
, MAPKAPK3
MAPKAPK3
MAP kinase-activated protein kinase 3 is an enzyme that in humans is encoded by the MAPKAPK3 gene.-Interactions:MAPKAPK3 has been shown to interact with MAPK14 and TCF3.-Further reading:...
, Activating transcription factor 2
Activating transcription factor 2
Activating transcription factor 2, also known as ATF2, is a protein that, in humans, is encoded by the ATF2 gene.-Function:This gene encodes a transcription factor that is a member of the leucine zipper family of DNA-binding proteins. This protein binds to the cAMP-responsive element , an octameric...
, MAPK1
MAPK1
Mitogen-activated protein kinase 1, also known as MAPK1, p42MAPK, and ERK2, is an enzyme that in humans is encoded by the MAPK1 gene.- Function :The protein encoded by this gene is a member of the MAP kinase family...
, AKT1
AKT1
RAC-alpha serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT1 gene. Multiple alternatively spliced transcript variants have been found for this gene.- Function :...
, Myocyte-specific enhancer factor 2A
Myocyte-specific enhancer factor 2A
Myocyte-specific enhancer factor 2A is a protein that in humans is encoded by the MEF2A gene. MEF2A is a transcription factor in the Mef2 family. In humans it is located on chromosome 15q26...
, MAP3K7IP1
MAP3K7IP1
Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 is an enzyme that in humans is encoded by the MAP3K7IP1 gene.This protein plays an important role in skin homeostasis, wound repair, and oncogenesis.-Interactions:...
, DUSP16
DUSP16
Dual specificity protein phosphatase 16 is an enzyme that in humans is encoded by the DUSP16 gene.-Interactions:DUSP16 has been shown to interact with MAPK14 and MAPK8IP1.-Further reading:...
, HtrA serine peptidase 2
HtrA serine peptidase 2
Serine protease HTRA2, mitochondrial is an enzyme that in humans is encoded by the HTRA2 gene.-Interactions:HtrA serine peptidase 2 has been shown to interact with MAPK14, XIAP and BIRC2.-External Links:...
, DUSP10
DUSP10
Dual specificity protein phosphatase 10 is an enzyme that in humans is encoded by the DUSP10 gene.-Interactions:DUSP10 has been shown to interact with MAPK14 and MAPK8.-Further reading:...
, Far upstream element-binding protein 1
Far upstream element-binding protein 1
Far upstream element-binding protein 1 is a protein that in humans is encoded by the FUBP1 gene.-Interactions:Far upstream element-binding protein 1 has been shown to interact with MAPK14 and SMN1.-Further reading:...
, Keratin 8
Keratin 8
Keratin, type I cytoskeletal 8 also known as cytokeratin-8 or keratin-8 is a keratin protein that in human is encoded by the KRT8 gene. It is often paired with keratin 18.-Utility as an immunohistochemical stain:...
and MAP2K6
MAP2K6
Dual specificity mitogen-activated protein kinase kinase 6 also known as MAP kinase kinase 6 or MAPK/ERK kinase 6 is an enzyme that in humans is encoded by the MAP2K6 gene, on chromosome 17.- Function :...
.