Matthias Mann
Encyclopedia
Matthias Mann is a scientist in the area of mass spectrometry
and proteomics
. Born 1959 in Germany he studied mathematics and physics at the University of Göttingen. He received his Ph.D. in 1988 at Yale University
where he worked in the group of John Fenn, who was later awarded the Nobel Prize in Chemistry
. After a postdoctoral fellowship at the University of Southern Denmark in Odense
he became group leader at the European Molecular Biology Laboratory (EMBL) in Heidelberg. Later he went back to Odense as a professor of bioinformatics. Since 2005 he has been a director at the Max Planck Institute of Biochemistry
in Munich. In addition, he will also become a principal investigator at the newly founded "Novo Nordisk Foundation Center for Protein Research" in Copenhagen.
His work has impact in various fields of mass spectrometry-based proteomics:
Mass spectrometry
Mass spectrometry is an analytical technique that measures the mass-to-charge ratio of charged particles.It is used for determining masses of particles, for determining the elemental composition of a sample or molecule, and for elucidating the chemical structures of molecules, such as peptides and...
and proteomics
Proteomics
Proteomics is the large-scale study of proteins, particularly their structures and functions. Proteins are vital parts of living organisms, as they are the main components of the physiological metabolic pathways of cells. The term "proteomics" was first coined in 1997 to make an analogy with...
. Born 1959 in Germany he studied mathematics and physics at the University of Göttingen. He received his Ph.D. in 1988 at Yale University
Yale University
Yale University is a private, Ivy League university located in New Haven, Connecticut, United States. Founded in 1701 in the Colony of Connecticut, the university is the third-oldest institution of higher education in the United States...
where he worked in the group of John Fenn, who was later awarded the Nobel Prize in Chemistry
Nobel Prize in Chemistry
The Nobel Prize in Chemistry is awarded annually by the Royal Swedish Academy of Sciences to scientists in the various fields of chemistry. It is one of the five Nobel Prizes established by the will of Alfred Nobel in 1895, awarded for outstanding contributions in chemistry, physics, literature,...
. After a postdoctoral fellowship at the University of Southern Denmark in Odense
Odense
The city of Odense is the third largest city in Denmark.Odense City has a population of 167,615 and is the main city of the island of Funen...
he became group leader at the European Molecular Biology Laboratory (EMBL) in Heidelberg. Later he went back to Odense as a professor of bioinformatics. Since 2005 he has been a director at the Max Planck Institute of Biochemistry
Max Planck Institute of Biochemistry
The Max Planck Institute of Biochemistry is a research institute of the Max Planck Society located in Martinsried, a suburb of Munich. The Institute was "founded in 1973 by the merger of three formerly independent institutes: the Max Planck Institute of Biochemistry, the Max Planck Institute of...
in Munich. In addition, he will also become a principal investigator at the newly founded "Novo Nordisk Foundation Center for Protein Research" in Copenhagen.
His work has impact in various fields of mass spectrometry-based proteomics:
- The peptide sequence tagPeptide sequence tagA peptide sequence tag is a piece of information about a peptide obtained by tandem mass spectrometry that can be used to identify this peptide in a protein database.-Mass spectrometry:...
approach developed at the EMBL was one of the first methods for the identification of peptides based on mass spectra and genome data. - Nano-electrospray (an electrosprayElectrosprayThe name electrospray is used for a device that employs electricity to disperse a liquid or for the fine aerosol resulted in this process. The method is sometimes improperly called electrohydrodynamic atomization. High voltage is applied to a liquid supplied through an emitter...
technique with very low flow rates) was the first method that allowed femtomole sequencing of proteins from polyacrylamide gels. - A recently developed metabolic labeling technique called SILACSilacSILAC is a technique based on mass spectrometry that detects differences in protein abundance among samples using non-radioactive isotopic labeling. It is a popular method for quantitative proteomics.-Procedure:Two populations of cells are cultivated in cell culture...
(stable isotope labeling with amino acids in cell culture) is widely used in quantitative proteomicsQuantitative proteomicsThe aim of quantitative proteomics is to obtain quantitative information about all proteins in a sample. Rather than just providing lists of proteins identified in a certain sample, quantitative proteomics yields information about differences between samples. For example, this approach can be used...
.
External links
- Homepage of the Mann department at the MPI of Biochemistry
- Nature article about the Novo Nordisk Foundation Center for Protein Research http://www.nature.com/nature/journal/v447/n7140/full/447012a.html