Mothers against decapentaplegic homolog 7

Mothers against decapentaplegic homolog 7 or SMAD7 is a protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

that in humans is encoded by the SMAD7 gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

.

SMAD7 is a protein that, as its name describes, is a homolog of the Drosophila

Drosophila

Drosophila is a genus of small flies, belonging to the family Drosophilidae, whose members are often called "fruit flies" or more appropriately pomace flies, vinegar flies, or wine flies, a reference to the characteristic of many species to linger around overripe or rotting fruit...

gene: "Mothers against decapentaplegic

Mothers against decapentaplegic

Mothers against decapentaplegic is a protein from the SMAD family that was discovered in Drosophila.The SMAD proteins are homologs of both the Drosophila protein "mothers against decapentaplegic" and the C. elegans protein SMA. The name is a combination of the two...

". It belongs to the SMAD

SMAD (protein)

SMADs are intracellular proteins that transduce extracellular signals from transforming growth factor beta ligands to the nucleus where they activate downstream TGF-β gene transcription....

family of proteins, which belong to the TGFβ superfamily of ligands. Like many other TGFβ family members, SMAD7 is involved in cell signalling. It is a TGFβ type 1 receptor antagonist

Receptor antagonist

A receptor antagonist is a type of receptor ligand or drug that does not provoke a biological response itself upon binding to a receptor, but blocks or dampens agonist-mediated responses...

. It blocks TGFβ1 and activin associating with the receptor, blocking access to SMAD2. It is an inhibitory SMAD (I-SMAD) and is enhanced by SMURF2

SMURF2

E3 ubiquitin-protein ligase SMURF2 is an enzyme that in humans is encoded by the SMURF2 gene.-Interactions:SMURF2 has been shown to interact with Mothers against decapentaplegic homolog 7, SCYE1, SMURF1, Mothers against decapentaplegic homolog 3, Ubiquitin C, Mothers against decapentaplegic homolog...

.

Smad7 enhances muscle differentiation.

Interactions

Mothers against decapentaplegic homolog 7 has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

with Mothers against decapentaplegic homolog 6

Mothers against decapentaplegic homolog 6

SMAD family member 6, also known as SMAD6, is a protein that in humans is encoded by the SMAD6 gene.SMAD6 is a protein that, as its name describes, is a homolog of the Drosophila gene "mothers against decapentaplegic". It belongs to the SMAD family of proteins, which belong to the TGFβ superfamily...

, Beta-catenin

Beta-catenin

Beta-catenin is a protein that in humans is encoded by the CTNNB1 gene. In Drosophila, the homologous protein is called armadillo...

, RNF111

RNF111

E3 ubiquitin-protein ligase Arkadia is an enzyme that in humans is encoded by the RNF111 gene.-Interactions:RNF111 has been shown to interact with Mothers against decapentaplegic homolog 7 and Mothers against decapentaplegic homolog 3....

, TGF beta receptor 1

TGF beta receptor 1

Transforming growth factor, beta receptor I is a TGF beta receptor. TGFBR1 is its human gene.-Interactions:...

, YAP1

YAP1

65 kDa Yes-associated protein is a protein that in humans is encoded by the YAP1 gene.-Interactions:YAP1 has been shown to interact with Mothers against decapentaplegic homolog 7, ERBB4, Sodium-hydrogen antiporter 3 regulator 1, TP53BP2 and P73....

, MAP3K7IP1

MAP3K7IP1

Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 is an enzyme that in humans is encoded by the MAP3K7IP1 gene.This protein plays an important role in skin homeostasis, wound repair, and oncogenesis.-Interactions:...

, SMURF2

SMURF2

, PIAS4

PIAS4

E3 SUMO-protein ligase PIAS4 also known as protein inhibitor of activated STAT protein 4 or protein inhibitor of activated STAT protein gamma is an enzyme that in humans is encoded by the PIAS4 gene.-Interactions:...

, EP300

EP300

E1A binding protein p300 also known as EP300 or p300 is a protein that, in humans, is encoded by the EP300 gene. This protein regulates the activity of many genes in tissues throughout the body...

, STRAP

STRAP

Serine-threonine kinase receptor-associated protein is an enzyme that in humans is encoded by the STRAP gene.-Interactions:STRAP has been shown to interact with Mothers against decapentaplegic homolog 6, TGF beta receptor 2, Mothers against decapentaplegic homolog 7, TGF beta receptor 1, Mothers...

and Mothers against decapentaplegic homolog 3

Mothers against decapentaplegic homolog 3

Mothers against decapentaplegic homolog 3 also known as SMAD family member 3 or SMAD3 is a protein that in humans is encoded by the SMAD3 gene. SMAD3 is a member of the SMAD family of proteins.The human SMAD3 gene is located on chromosome 15...

Interactions

Further reading