Myelin-associated glycoprotein
Encyclopedia
Myelin-associated glycoprotein (MAG, Siglec-4) is a cell membrane
glycoprotein
that is a member of the SIGLEC
family of proteins and is a functional ligand of the NOGO-66 receptor, NgR. MAG is believed to be involved in myelination during nerve
regeneration.
Cell membrane
The cell membrane or plasma membrane is a biological membrane that separates the interior of all cells from the outside environment. The cell membrane is selectively permeable to ions and organic molecules and controls the movement of substances in and out of cells. It basically protects the cell...
glycoprotein
Glycoprotein
Glycoproteins are proteins that contain oligosaccharide chains covalently attached to polypeptide side-chains. The carbohydrate is attached to the protein in a cotranslational or posttranslational modification. This process is known as glycosylation. In proteins that have segments extending...
that is a member of the SIGLEC
SIGLEC
Siglecs, short for sialic acid binding Ig-like lectins are cell surface receptors and members of the immunoglobulin superfamily that recognize sugars. Their ability to recognize carbohydrates using an immunoglobulin domain places them in the group of I-type lectins...
family of proteins and is a functional ligand of the NOGO-66 receptor, NgR. MAG is believed to be involved in myelination during nerve
Nerve
A peripheral nerve, or simply nerve, is an enclosed, cable-like bundle of peripheral axons . A nerve provides a common pathway for the electrochemical nerve impulses that are transmitted along each of the axons. Nerves are found only in the peripheral nervous system...
regeneration.