Myxoid liposarcoma
Encyclopedia
A myxoid liposarcoma is a malignant
adipose tissue neoplasm
.
It is associated with a fusion between DDIT3
or "CHOP" (at 12q13.1-q13.2) and FUS
or "TLS" (at 16p11.2) or EWS
(at 22q12.2).
The specific translocation of FUS-DDIT3 is t(12;16)(q13;p11).
Cancer
Cancer , known medically as a malignant neoplasm, is a large group of different diseases, all involving unregulated cell growth. In cancer, cells divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. The cancer may also spread to more distant parts of the...
adipose tissue neoplasm
Adipose tissue neoplasm
An adipose tissue neoplasm is a neoplasm derived from adipose tissue.An example is lipoma....
.
It is associated with a fusion between DDIT3
DNA damage-inducible transcript 3
DNA damage-inducible transcript 3 is a protein that in humans is encoded by the DDIT3 gene.-Interactions:DNA damage-inducible transcript 3 has been shown to interact with Casein kinase 2, alpha 1, JunD, RPS3A, ATF3, CEBPB, C-jun and C-Fos....
or "CHOP" (at 12q13.1-q13.2) and FUS
FUS
RNA-binding protein FUS is a protein that in humans is encoded by the FUS gene.- Function :The N-terminal end of FUS appears to be involved in transcriptional activation, while the C-terminal end is involved in protein and RNA binding...
or "TLS" (at 16p11.2) or EWS
Ewing sarcoma breakpoint region 1
RNA-binding protein EWS is a protein that in humans is encoded by the EWSR1 gene.-Interactions:Ewing sarcoma breakpoint region 1 has been shown to interact with POU4F1, SF1, BARD1, Small nuclear ribonucleoprotein polypeptide C, PTK2B and Zinc finger protein 165.ERG, ATF-1,-External links:* on the...
(at 22q12.2).
The specific translocation of FUS-DDIT3 is t(12;16)(q13;p11).